Modern science versus the stigma of obesity

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Principles of neural science

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Prevalence and trends in obesity among US adults, 1999–2000

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Leptin and the regulation of body weight in mammals

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Obesity as a medical problem

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Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

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Role of leptin in the neuroendocrine response to fasting

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Changes in Energy Expenditure Resulting from Altered Body Weight

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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

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Principles of Neural Science

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

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Leptin-regulated endocannabinoids are involved in maintaining food intake

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Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

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The Body-Mass Index of Twins Who Have Been Reared Apart

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The Response to Long-Term Overfeeding in Identical Twins

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Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

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Leptin-Replacement Therapy for Lipodystrophy

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Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain

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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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The Need to Feed

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Obesity Wars

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

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Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

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Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

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Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

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Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

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Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans

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Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

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A Twin Study of Human Obesity

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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

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Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

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PTP1B Regulates Leptin Signal Transduction In Vivo

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Molecular characterization of the mouse agouti locus

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βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

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Genetics of body-weight regulation

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Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

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Key enzyme in leptin-induced anorexia

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Melanocortin receptors in leptin effects

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Dietary obesity in nine inbred mouse strains

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Activation of Central Melanocortin Pathways by Fenfluramine

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Treatment of Obesity by Moderate and Severe Caloric Restriction: Results of Clinical Research Trials

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Bariatric surgery and long-term control of morbid obesity

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Virus-Assisted Mapping of Neural Inputs to a Feeding Center in the Hypothalamus

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Modulation of Brain Reward Circuitry by Leptin

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The heritability of body mass index among an international sample of monozygotic twins reared apart.

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Partial leptin deficiency and human adiposity

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A war on obesity, not the obese.

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Body mass index and mortality among nonsmoking older persons. The Framingham Heart Study

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The spontaneous activity and food intake of rats with hypothalamic lesions

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A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

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Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible

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Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance

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Minireview: Human Obesity—Lessons from Monogenic Disorders

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Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

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Long-term Pharmacotherapy of Obesity 2000

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Appetite and the regulation of body composition

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Effect of Leptin Replacement on Pituitary Hormone Regulation in Patients with Severe Lipodystrophy

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A comparison of the effects on central 5‐HT function of sibutramine hydrochloride and other weight‐modifying agents

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Short- and Long-Term Changes in Serum Leptin in Dieting Obese Women: Effects of Caloric Restriction and Weight Loss

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Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice

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Hyperleptinemia Precipitates Diet-Induced Obesity in Transgenic Mice Overexpressing Leptin

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Die Quelle der thierischen Wärme

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Memoir on Heat Read to the Royal Academy of Sciences, 28 June 1783

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Counting Calories—Caveat Emptor

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Counting calories--caveat emptor

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Morbid Obesity: Perceptions of Character and Comorbidities in Falstaff

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Anti-obesity drug discovery: advances and challenges

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A common genetic variant is associated with adult and childhood obesity.

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Sleep curtailment is accompanied by increased intake of calories from snacks

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Leptin and the endocrine control of energy balance

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Insights into the role of the microbiome in obesity and type 2 diabetes

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The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

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Leptin at 14 y of age: an ongoing story

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Issues for DSM-V: Should obesity be included as a brain disorder?

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Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment

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Sleep deprivation is associated with lower diet quality indices and higher rate of general and central obesity among young female students in Iran

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Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in‐vivo μPET imaging ([¹¹C] raclopride) and in‐vitro ([³H] spiperone) autoradiography

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Short and long-term energy intake patterns and their implications for human body weight regulation

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Is the Hippocratic Oath an anachronism?

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Is the Hippocratic Oath an anachronism?

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The hippocratic oath: an anachronism?

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Weight stigma in physiotherapists: implications for education, practice and physiotherapy

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