Spiga, Francesca

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis

The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Domingo, P., Mur, I., Mateo, G. M., Gutierrez, M. D. M., Pomar, V., de Benito, N., Corbacho, N., Herrera, S., Millan, L., et al. (2021) · JAMA

COVID-19 Clinical Research StudiesRespiratory Support and Mechanisms

Cited by 678

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

Gjerstad, J. K., Lightman, S. L., & Spiga, F. (2018) · Stress

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 437

HPA Axis‐Rhythms

Spiga, F., Walker, J. J., Terry, J. R., & Lightman, S. L. (2014) · Comprehensive Physiology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 267

The significance of glucocorticoid pulsatility

Lightman, S. L., Wiles, C. C., Atkinson, H. C., Henley, D. E., Russell, G. M., Leendertz, J. A., McKenna, M. A., Spiga, F., Wood, S. A., & Conway-Campbell, B. L. (2008) · European Journal of Pharmacology

Stress Responses and CortisolEstrogen and related hormone effects

Cited by 241

The origin of glucocorticoid hormone oscillations

Walker, J. J., Spiga, F., Waite, E., Zhao, Z., Kershaw, Y., Terry, J. R., & Lightman, S. L. (2012) · PLoS Biology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 189

ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion

Spiga, F., Waite, E. J., Liu, Y., Kershaw, Y. M., Aguilera, G., & Lightman, S. L. (2011) · Endocrinology

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 97

Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery*

Gibbison, B., Spiga, F., Walker, J. J., Russell, G. M., Stevenson, K., Kershaw, Y., Zhao, Z., Henley, D., Angelini, G. D., & Lightman, S. L. (2015) · Critical Care Medicine

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 87

Mathematical Modelling of Endocrine Systems

Zavala, E., Wedgwood, K. C. A., Voliotis, M., Tabak, J., Spiga, F., Lightman, S. L., & Tsaneva-Atanasova, K. (2019) · Trends in Endocrinology & Metabolism

Circadian rhythm and melatoninGene Regulatory Network Analysis

Cited by 81

Rapid intra-adrenal feedback regulation of glucocorticoid synthesis

Walker, J. J., Spiga, F., Gupta, R., Zhao, Z., Lightman, S. L., & Terry, J. R. (2015) · Journal of The Royal Society Interface

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 70

Effect of the Glucocorticoid Receptor Antagonist Org 34850 on Basal and Stress‐Induced Corticosterone Secretion

Spiga, F., Harrison, L. R., Wood, S. A., Atkinson, H. C., MacSweeney, C. P., Thomson, F., Craighead, M., Grassie, M., & Lightman, S. L. (2007) · Journal of Neuroendocrinology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 53

Dynamic responses of the adrenal steroidogenic regulatory network

Spiga, F., Zavala, E., Walker, J. J., Zhao, Z., Terry, J. R., & Lightman, S. L. (2017) · Proceedings of the National Academy of Sciences

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 52

Temporal Effect of Adrenocorticotrophic Hormone on Adrenal Glucocorticoid Steroidogenesis: Involvement of the Transducer of Regulated Cyclic AMP-Response Element-Binding Protein Activity: TORC2 and adrenal glucocorticoid steroidogenesis

Spiga, F., Liu, Y., Aguilera, G., & Lightman, S. L. (2011) · Journal of Neuroendocrinology

Adrenal Hormones and DisordersEstrogen and related hormone effects

Cited by 50

60 Years of neuroendocrinology: glucocorticoid dynamics: insights from mathematical, experimental and clinical studies

Spiga, F., Walker, J. J., Gupta, R., Terry, J. R., & Lightman, S. L. (2015) · Journal of Endocrinology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 48

Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic–pituitary–adrenal axis activity

Spiga, F., Harrison, L. R., Wood, S., Knight, D. M., MacSweeney, C. P., Thomson, F., Craighead, M., & Lightman, S. L. (2009) · Journal of Endocrinology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 40

Transcriptional regulation of episodic glucocorticoid secretion

Liu, Y., Smith, L. I., Huang, V., Poon, V., Coello, A., Olah, M., Spiga, F., Lightman, S. L., & Aguilera, G. (2013) · Molecular and Cellular Endocrinology

Adrenal Hormones and DisordersEstrogen and related hormone effects

Cited by 38

Recovery from Disrupted Ultradian Glucocorticoid Rhythmicity Reveals a Dissociation Between Hormonal and Behavioural Stress Responsiveness

Sarabdjitsingh, R. A., Spiga, F., Oitzl, M. S., Kershaw, Y., Meijer, O. C., Lightman, S. L., & De Kloet, E. R. (2010) · Journal of Neuroendocrinology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 35

Effect of vasopressin 1b receptor blockade on the hypothalamic–pituitary–adrenal response of chronically stressed rats to a heterotypic stressor

Spiga, F., Harrison, L. R., MacSweeney, C. P., Thomson, F. J., Craighead, M., & Lightman, S. L. (2009) · Journal of Endocrinology

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 30

Co-culture of monocytes and zona fasciculata adrenal cells: An in vitro model to study the immune-adrenal cross-talk

Fudulu, D. P., Horn, G., Hazell, G., Lefrançois-Martinez, A.-M., Martinez, A., Angelini, G. D., Lightman, S. L., & Spiga, F. (2021) · Molecular and Cellular Endocrinology

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 11

Dynamics of the HPA Axis: A Systems Modeling Approach

Terry, J. R., Walker, J. J., Spiga, F., & Lightman, S. L. (2016) · Computational Neuroendocrinology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 5