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Cited by 35Stress Responses and CortisolAdrenal Hormones and DisordersCircadian rhythm and melatonin

Recovery from Disrupted Ultradian Glucocorticoid Rhythmicity Reveals a Dissociation Between Hormonal and Behavioural Stress Responsiveness

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Sarabdjitsingh, R. A., Spiga, F., Oitzl, M. S., Kershaw, Y., Meijer, O. C., Lightman, S. L., De Kloet, E. R.·2010·Journal of Neuroendocrinology
DOI 10.1111/j.1365-2826.2010.02004.xPMC PMC4976802
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Abstract

Ultradian release of glucocorticoids is thought to be essential for homeostasis and health. Furthermore, deviation from this pulsatile release pattern is considered to compromise resilience to stress‐related disease, even after hormone levels have normalised. In the present study, we investigate how constant exposure to different concentrations of corticosterone affects diurnal and ultradian pulsatility. The rate of recovery in pulsatile hypothalamic‐pituitary‐adrenal (HPA) activity after withdrawal of exogenous corticosterone is also examined. Finally, the behavioural and neuroendocrine responsiveness to an audiogenic stressor is studied. Adrenally intact male rats were subcutaneously implanted with vehicle, 40% or 100% corticosterone pellets for 7 days. The continuous release of corticosterone from these implants abolished diurnal and ultradian corticosterone variation, as measured with high‐frequency automated blood sampling. Pellet removal on post‐surgery day 8 allowed rapid recovery of endogenous rhythms in animals previously exposed to daily average concentrations (40%) but not after exposure to high concentrations (100%) of corticosterone. Behavioural and neuroendocrine responsiveness to stress was distinctly different between the treatment groups. Audiogenic stimulation 1 day after pellet removal resulted in a similar corticosterone response in animals previously exposed to 40% corticosterone or vehicle. The 40% pellet group, however, showed less and shorter behavioural activity (i.e. locomotion, risk assessment) to noise stress compared to 100% corticosterone and vehicle‐treated animals. In conclusion, unlike the animals impanted with 100% corticosterone, we find that basal HPA axis activity in the 40% group, which had mean daily levels of circulating corticosterone in the physiological range, rapidly reverts to the characteristic pulsatile pattern of corticosterone secretion. Upon reinstatement of the ultradian rhythm, and despite the fact that these animals did not differ from controls in their response to noise stress, they did show substantial changes in their behavioural response to stress.

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  • Early attempts to establish objective markers for diagnosing depression based on HPA hormone levels and patterns have not been successful.

    “Early attempts of establishing objective markers for diagnosing depression based on hormone levels and patterns produced by the HPA axis have not been successful [9, 12, 43].”

    From Patient specific modeling of the HPA axis related to clinical diagnosis of depression (2017) · cites this paper as [43]

    The Discussion (Persistence of behavioural effects; page unavailable) reports that normal HPA stress responses in rats need not indicate normal behavioural responses. It does not address early attempts to diagnose depression using HPA hormone levels or patterns, or whether those attempts succeeded. Searches for depression diagnosis and hormonal biomarkers found no passage establishing that claim. (LLM, conf=0.74)

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Authors
Sarabdjitsingh, R. A., Spiga, F., Oitzl, M. S., Kershaw, Y., Meijer, O. C., Lightman, S. L., & De Kloet, E. R.
Affiliations
  • Leiden University (NL)
  • University of Bristol (GB)
Corresponding author
Sarabdjitsingh, R. A.
ORCID
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2010-07-16
Volume
22
Issue
8
Pages
862-871
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
DOI
10.1111/j.1365-2826.2010.02004.x
PMC
PMC4976802
OpenAlex
W2061591919
Cited by
35
References
10
Citations by year
2023: 6 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
1.25
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Explore Bristol Research (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
  • Wellcome Trust (089647)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (017.002.021)
  • Biotechnology and Biological Sciences Research Council (BB/H015779/1)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
corticosterone, hypothalamic-pituitary-adrenal axis, pulsatile hormone secretion, noise stress, stress behavior, risk assessment, locomotion
MeSH terms
Animals, Anti-Inflammatory Agents, Behavior, Animal, Biological Clocks, Circadian Rhythm, Corticosterone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress, Physiological, Stress, Psychological, Rats, Sprague-Dawley, Rats

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