Schaffer, Chris B.

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

Horton, N. G., Wang, K., Kobat, D., Clark, C. G., Wise, F. W., Schaffer, C. B., & Xu, C. (2013) · Nature Photonics

Advanced Fluorescence Microscopy TechniquesOptical Imaging and Spectroscopy Techniques

Cited by 1,505

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Snyder, H. M., Corriveau, R. A., Craft, S., Faber, J. E., Greenberg, S. M., Knopman, D., Lamb, B. T., Montine, T. J., Nedergaard, M., Schaffer, C. B., et al. (2015) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 603

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

Cruz Hernández, J. C., Bracko, O., Kersbergen, C. J., Muse, V., Haft-Javaherian, M., Berg, M., Park, L., Vinarcsik, L. K., Ivasyk, I., Rivera, D. A., et al. (2019) · Nature Neuroscience

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 508

Ultrafast Processes for Bulk Modification of Transparent Materials

Itoh, K., Watanabe, W., Nolte, S., & Schaffer, C. B. (2006) · MRS Bulletin

Laser Material Processing TechniquesLaser-Matter Interactions and Applications

Cited by 463

Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion

Schaffer, C. B., Friedman, B., Nishimura, N., Schroeder, L. F., Tsai, P. S., Ebner, F. F., Lyden, P. D., & Kleinfeld, D. (2006) · PLoS Biology

Blood properties and coagulationBarrier Structure and Function Studies

Cited by 400

Penetrating arterioles are a bottleneck in the perfusion of neocortex

Nishimura, N., Schaffer, C. B., Friedman, B., Lyden, P. D., & Kleinfeld, D. (2007) · Proceedings of the National Academy of Sciences

Blood properties and coagulationBarrier Structure and Function Studies

Cited by 367

Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke

Nishimura, N., Schaffer, C. B., Friedman, B., Tsai, P. S., Lyden, P. D., & Kleinfeld, D. (2006) · Nature Methods

Acute Ischemic Stroke ManagementOptical Imaging and Spectroscopy Techniques

Cited by 308

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

Koizumi, K., Hattori, Y., Ahn, S. J., Buendia, I., Ciacciarelli, A., Uekawa, K., Wang, G., Hiller, A., Zhao, L., Voss, H. U., et al. (2018) · Nature Communications

Neurological Disease Mechanisms and TreatmentsCerebrovascular and genetic disorders

Cited by 179

Limitations of collateral flow after occlusion of a single cortical penetrating arteriole

Nishimura, N., Rosidi, N. L., Iadecola, C., & Schaffer, C. B. (2010) · Journal of Cerebral Blood Flow & Metabolism

Acute Ischemic Stroke ManagementBarrier Structure and Function Studies

Cited by 117

Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries

Nguyen, J., Nishimura, N., Fetcho, R. N., Iadecola, C., & Schaffer, C. B. (2011) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesBlood properties and coagulation

Cited by 95

Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration

Rosidi, N. L., Zhou, J., Pattanaik, S., Wang, P., Jin, W., Brophy, M., Olbricht, W. L., Nishimura, N., & Schaffer, C. B. (2011) · PLoS ONE

Intracerebral and Subarachnoid Hemorrhage ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 87

High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow.

Bracko, O., Vinarcsik, L. K., Cruz Hernández, J. C., Ruiz-Uribe, N. E., Haft-Javaherian, M., Falkenhain, K., Ramanauskaite, E. M., Ali, M., Mohapatra, A., Swallow, M. A., et al. (2020) · Scientific Reports

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 85

RNA structures and dynamics with Å resolution revealed by x-ray free-electron lasers

Zielinski, K. A., Sui, S., Pabit, S. A., Rivera, D. A., Wang, T., Hu, Q., Kashipathy, M. M., Lisova, S., Schaffer, C. B., Mariani, V., et al. (2023) · Science Advances

RNA and protein synthesis mechanismsEnzyme Structure and Function

Cited by 17