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Cited by 603Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

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Snyder, Heather M., Corriveau, Roderick A., Craft, Suzanne, Faber, James E., Greenberg, Steven M., Knopman, David, Lamb, Bruce T., Montine, Thomas J. +12 more·2015·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2014.10.008PMC PMC4731036
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Abstract

Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.

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  • Microbleeds develop in the absence of Aβ pathology and are associated with cognitive impairment and dementia, as shown in patients with small vessel disease of the brain that is estimated to contribute to 50% of all dementias worldwide including AD.

    “Importantly, microbleeds develop in the absence of A 𝛃 pathology and are associated with cognitive impairment and dementia, as shown in patients with small vessel disease of the brain that is estimated to contribute to 50% of all dementias wordwide including AD (224, 550, 637).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [550]

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Cited by

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Authors
Snyder, H. M., Corriveau, R. A., Craft, S., Faber, J. E., Greenberg, S. M., Knopman, D., Lamb, B. T., Montine, T. J., Nedergaard, M., Schaffer, C. B., Schneider, J. A., Wellington, C., Wilcock, D. M., Zipfel, G. J., Zlokovic, B., Bain, L. J., Bosetti, F., Galis, Z. S., Koroshetz, W., & Carrillo, M. C.
Affiliations
  • Alzheimer's Association (US)
  • National Institutes of Health (US)
  • Wake Forest University Health Sciences (US)
  • University of North Carolina at Chapel Hill (US)
  • Harvard University (US)
  • Mayo Clinic (US)
  • Cleveland Clinic (US)
  • University of Washington (US)
  • University of Rochester Medicine (US)
  • Cornell University (US)
  • Rush University Medical Center (US)
  • University of British Columbia (CA)
  • University of Kentucky (US)
  • Washington University in St. Louis (US)
  • Department of Physiology University of Southern California Los Angeles CA USA
  • Independent Science Writer Elverson PA USA
  • Medical & Scientific Relations Alzheimer's Association Chicago IL USA
Corresponding author
Snyder, Heather M.
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2014-12-12
Volume
11
Issue
6
Pages
710-717
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1016/j.jalz.2014.10.008
PMC
PMC4731036
OpenAlex
W2057164916
Cited by
603
References
24
Citations by year
2026: 27 · 2025: 53 · 2024: 36 · 2023: 39 · 2022: 56 · 2021: 65 · 2020: 73 · 2019: 69 · 2018: 56 · 2017: 43 · 2016: 57 · 2015: 27 · 2014: 1
FWCI
5.91
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Novo Nordisk Fonden (NNF13OC0004258)
  • National Institute on Aging (R01AG048769)
  • National Institute of Neurological Disorders and Stroke (R01NS078304, R01NS078167, R01NS079637)
  • National Institute of Dental and Craniofacial Research (R01DE022743)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease
MeSH terms
Animals, Brain, Cerebrovascular Disorders, Cognition Disorders, Congresses as Topic, Dementia, Humans, Societies, United States, National Heart, Lung, and Blood Institute (U.S.), National Institute of Neurological Disorders and Stroke (U.S.)

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