High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow.
Open accessAbstract
Obesity is linked to increased risk for and severity of Alzheimer’s disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We recently showed that non-flowing capillaries, caused by adhered neutrophils, contribute to CBF reduction in mouse models of AD. Because obesity could exacerbate the vascular inflammation likely underlying this neutrophil adhesion, we tested links between obesity and AD by feeding APP/PS1 mice a high fat diet (Hfd) and evaluating behavioral, physiological, and pathological changes. We found trends toward poorer memory performance in APP/PS1 mice fed a Hfd, impaired social interactions with either APP/PS1 genotype or a Hfd, and synergistic impairment of sensory-motor function in APP/PS1 mice fed a Hfd. The Hfd led to increases in amyloid-beta monomers and plaques in APP/PS1 mice, as well as increased brain inflammation. These results agree with previous reports showing obesity exacerbates AD-related pathology and symptoms in mice. We used a crowd-sourced, citizen science approach to analyze imaging data to determine the impact of the APP/PS1 genotype and a Hfd on capillary stalling and CBF. Surprisingly, we did not see an increase in the number of non-flowing capillaries or a worsening of the CBF deficit in APP/PS1 mice fed a Hfd as compared to controls, suggesting that capillary stalling is not a mechanistic link between a Hfd and increased severity of AD in mice. Reducing capillary stalling by blocking neutrophil adhesion improved CBF and short-term memory function in APP/PS1 mice, even when fed a Hfd.
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Addition of a high fat/high sugar diet exacerbates Alzheimer's disease phenotypes in mouse models relevant to early-onset AD.
“Also, the addition of an HFD exacerbated AD phenotypes in mouse models relevant to early-onset AD (Knight et al., 2014; Jones et al., 2019; Bracko et al., 2020; Robison et al., 2020; Jones et al., 2021).”
From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Bracko et al., 2020
The Discussion reports that a high-fat diet increased amyloid pathology, inflammation, and behavioral deficits in APP/PS1 mice. The Methods describe the diet as high-fat but do not establish the claim’s additional “high sugar” characterization; the verbatim citing sentence itself says only “HFD.” (LLM, conf=0.84)
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Cites
The Epidemiology of Obesity: A Big Picture
Hruby, A., & Hu, F. B. (2014) · PharmacoEconomics · doi:10.1007/s40273-014-0243-x · Cited by 3,006 · see citing works
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814 · see citing works
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823 · see citing works
Diffeomorphic demons: Efficient non-parametric image registration
Vercauteren, T. K., Pennec, X., Aymeric Perchant, B., & Ayache, N. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.040 · Cited by 1,589 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · see citing works
Single App knock-in mouse models of Alzheimer’s disease
Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., & Saido, T. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3697 · Cited by 1,447 · see citing works
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291 · see citing works
Midlife cardiovascular risk factors and risk of dementia in late life
Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C., & Yaffe, K. (2005) · Neurology · doi:10.1212/01.wnl.0000149519.47454.f2 · Cited by 1,238 · see citing works
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,125 · see citing works
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes
Nortley, R., Korte, N., Izquierdo, P., Hirunpattarasilp, C., Mishra, A., Jaunmuktane, Z., Kyrargyri, V., Pfeiffer, T., Khennouf, L., Madry, C., et al. (2019) · Science · doi:10.1126/science.aav9518 · Cited by 682 · see citing works
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow
Blinder, P., Tsai, P. S., Kaufhold, J. P., Knutsen, P. M., Suhl, H., & Kleinfeld, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3426 · Cited by 573 · see citing works
Cruz Hernández, J. C., Bracko, O., Kersbergen, C. J., Muse, V., Haft-Javaherian, M., Berg, M., Park, L., Vinarcsik, L. K., Ivasyk, I., Rivera, D. A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0329-4 · Cited by 508 · see citing works
Self-citationInflammatory Links Between High Fat Diets and Diseases
Duan, Y., Zeng, L., Zheng, C., Song, B., Li, F., Kong, X., & Xu, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02649 · Cited by 495 · see citing works
Midlife overweight and obesity increase late-life dementia risk
Xu, W., Atti, A. R., Gatz, M., Pedersen, N. L., Johansson, B. E. A., & Fratiglioni, L. (2011) · Neurology · doi:10.1212/wnl.0b013e3182190d09 · Cited by 479 · see citing works
Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia
Rusanen, M., Kivipelto, M., Quesenberry, C. P., Zhou, J., & Whitmer, R. A. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.393 · Cited by 324 · see citing works
Nishimura, N., Schaffer, C. B., Friedman, B., Tsai, P. S., Lyden, P. D., & Kleinfeld, D. (2006) · Nature Methods · doi:10.1038/nmeth844 · Cited by 308 · see citing works
Self-citationHao, S., Dey, A., Yu, X., & Stranahan, A. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.023 · Cited by 302 · see citing works
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288 · see citing works
Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function
Bocarsly, M. E., Fasolino, M., Kane, G. A., LaMarca, E. A., Kirschen, G. W., Karatsoreos, I. N., McEwen, B. S., & Gould, E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511593112 · Cited by 250 · see citing works
Fatty Acids Consumption: The Role Metabolic Aspects Involved in Obesity and Its Associated Disorders
Figueiredo, P. S., Inada, A. C., Marcelino, G., Cardozo, C. M. L., Freitas, K. D. C., Guimarães, R. D. C. A., de Castro, A. P., do Nascimento, V. A., & Hiane, P. A. (2017) · Nutrients · doi:10.3390/nu9101158 · Cited by 243 · see citing works
Knight, E. M., Martins, I. V. A., Gümüsgöz, S., Allan, S. M., & Lawrence, C. B. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.010 · Cited by 232 · see citing works
Willeumier, K. C., Taylor, D. V., & Amen, D. G. (2011) · Obesity · doi:10.1038/oby.2011.16 · Cited by 223 · see citing works
Obesity and vascular dysfunction
Stapleton, P. A., James, M. E., Goodwill, A. G., & Frisbee, J. C. (2008) · Pathophysiology · doi:10.1016/j.pathophys.2008.04.007 · Cited by 221 · see citing works
Obesity and dementia: Adipokines interact with the brain
Arnoldussen, I. A. C., Kiliaan, A. J., & Gustafson, D. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.002 · Cited by 219 · see citing works
Obesity as a risk factor for Alzheimer's disease: weighing the evidence
Alford, S., Patel, D. K., Perakakis, N., & Mantzoros, C. S. (2017) · Obesity Reviews · doi:10.1111/obr.12629 · Cited by 219 · see citing works
Obesity and cardiovascular diseases
Kachur, S. M., Lavie, C. J., Schutter, A. D., Milani, R. V., & Ventura, H. O. (2017) · Minerva Medica · doi:10.23736/s0026-4806.17.05022-4 · Cited by 217 · see citing works
Buckman, L. B., Hasty, A. H., Flaherty, D. K., Buckman, C. T., Thompson, M. M., Matlock, B. K., Weller, K., & Ellacott, K. L. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.06.007 · Cited by 216 · see citing works
Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization
Ahn, H. J., Zamolodchikov, D., Cortés‐Canteli, M., Norris, E. H., Glickman, J. F., & Strickland, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010373107 · Cited by 211 · see citing works
Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction
Lavi, S., Gaitini, D. E., Milloul, V., & Jacob, G. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00014.2006 · Cited by 211 · see citing works
Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 204 · see citing works
Cerebral blood flow in Alzheimer’s disease
Roher, A., Debbins, J., Malek-Ahmadi, M., Chen, K.-W., Pipe, J., Maze, S., Belden, C. M., Maarouf, C., Thiyyagura, P., Mo, H., et al. (2012) · Vascular Health and Risk Management · doi:10.2147/vhrm.s34874 · Cited by 194 · see citing works
Yang, Y., Zhong, Z., Wang, B., Xia, X., Yao, W., Huang, L., Wang, Y., & Ding, W. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0437-1 · Cited by 179 · see citing works
The microcirculation: a key player in obesity-associated cardiovascular disease
Sorop, O., Olver, T. D., van de Wouw, J., HEINONEN, I. H. A., van Duin, R. W. B., Duncker, D. J., & Merkus, D. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx093 · Cited by 174 · see citing works
Santisakultarm, T. P., Cornelius, N. R., Nishimura, N., Schafer, A. I., Silver, R. T., Doerschuk, P. C., Olbricht, W. L., & Schaffer, C. B. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00417.2011 · Cited by 161 · see citing works
Self-citationPuig, K. L., Floden, A. M., Adhikari, R., Golovko, M. Y., & Combs, C. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030378 · Cited by 152 · see citing works
Besser, L. M., Gill, D. P., Monsell, S. E., Brenowitz, W. D., Meranus, D. H., Kukull, W. A., & Gustafson, D. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000005 · Cited by 146 · see citing works
Primary Cerebral Blood Flow Deficiency and Alzheimer's Disease: Shadows and Lights
Mazza, M., Marano, G., Traversi, G., Bria, P., & Mazza, S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-090700 · Cited by 127 · see citing works
Sah, S. K., Lee, C. M., Jang, J., & Park, G. H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.122 · Cited by 127 · see citing works
High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice
Thériault, P., ElAli, A., & Rivest, S. (2016) · Oncotarget · doi:10.18632/oncotarget.12179 · Cited by 119 · see citing works
Levin-Allerhand, J. A., Lominska, C. E., & Smith, J. D. (2002) · PubMed · Cited by 118 · see citing works
Theoretical Models for Regulation of Blood Flow
Secomb, T. W. (2008) · Microcirculation · doi:10.1080/10739680802350112 · Cited by 110 · see citing works
Walker, J. M., Dixit, S., Saulsberry, A. C., May, J. M., & Harrison, F. E. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.01.004 · Cited by 110 · see citing works
Haft‐Javaherian, M., Fang, L., Muse, V., Schaffer, C. B., Nishimura, N., & Sabuncu, M. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213539 · Cited by 110 · see citing works
Self-citationHigh fat diet increases cognitive decline and neuroinflammation in a model of orexin loss
Duffy, C. M., Hofmeister, J. J., Nixon, J. P., & Butterick, T. A. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.008 · Cited by 107 · see citing works
Amyloid Precursor Protein Expression Is Upregulated in Adipocytes in Obesity
Lee, Y., Tharp, W. G., Maple, R. L., Nair, S., Permana, P. A., & Pratley, R. E. (2008) · Obesity · doi:10.1038/oby.2008.267 · Cited by 102 · see citing works
Smith, A. F., Doyeux, V., Berg, M., Peyrounette, M., Haft‐Javaherian, M., Larue, A.-E., Slater, J. H., Lauwers, F., Blinder, P., Tsai, P. S., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00233 · Cited by 102 · see citing works
Self-citationThe Effects of Obesity on the Cerebral Vasculature
Dorrance, A. M., Matin, N., & Pires, P. W. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161112666140423222411 · Cited by 98 · see citing works
Wirths, O., Breyhan, H., Schäfer, S., Roth, C., & Bayer, T. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.004 · Cited by 97 · see citing works
The effects of body mass index on cerebral blood flow velocity
Selim, M. H., Jones, R. N., Novák, P., Zhao, P., & Novak, V. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-008-0490-z · Cited by 94 · see citing works
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
Nam, K. N., Mounier, A., Wolfe, C. M., Fitz, N. F., Carter, A. Y., Castranio, E. L., Kamboh, H., Reeves, V. L., Wang, J., Han, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04412-2 · Cited by 94 · see citing works
Long-Term Dabigatran Treatment Delays Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Cortés‐Canteli, M., Kruyer, A., Fernandez‐Nueda, I., Marcos-Díaz, A., Cerón, C., Richards, A. T., Jno-Charles, O. C., Rodríguez, I., Callejas, S., Norris, E. H., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.07.081 · Cited by 91 · see citing works
Motor impairment in Alzheimer’s disease and transgenic Alzheimer’s disease mouse models
Wirths, O., & Bayer, T. A. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00373.x · Cited by 86 · see citing works
Rapid and reversible impairment of episodic memory by a high-fat diet in mice
McLean, F. H., Grant, C., Morris, A. C., Horgan, G. W., Polanski, A. J., Allan, K., Campbell, F., Langston, R. F., & Williams, L. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-30265-4 · Cited by 85 · see citing works
Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice
Bracko, O., Njiru, B. N., Swallow, M. A., Ali, M. A., Haft‐Javaherian, M., & Schaffer, C. B. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19873658 · Cited by 85 · see citing works
Self-citationChoi, J. H. K., Berger, J. D., Mazzella, M. J., Morales‐Corraliza, J., Cataldo, A. M., Nixon, R. A., Ginsberg, S. D., Levy, E., & Mathews, P. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06277.x · Cited by 83 · see citing works
Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
Klohs, J., Rudin, M., Shimshek, D. R., & Beckmann, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00032 · Cited by 82 · see citing works
Rollins, C. P. E., Gallino, D., Kong, V., Ayranci, G., Devenyi, G. A., Germann, J., & Chakravarty, M. M. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.11.016 · Cited by 79 · see citing works
Underwood, E. L., & Thompson, L. T. (2015) · Neural Plasticity · doi:10.1155/2016/7385314 · Cited by 69 · see citing works
Alosco, M. L., Spitznagel, M. B., Raz, N., Cohen, R. A., Sweet, L. H., Colbert, L. H., Josephson, R., van Dulmen, M. H. M., Hughes, J. W., Rosneck, J., et al. (2012) · Cerebrovascular Diseases Extra · doi:10.1159/000343222 · Cited by 62 · see citing works
Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice
Ramos‐Rodríguez, J. J., Ortiz-Barajas, O., Gamero-Carrasco, C., de la Rosa, P. R., Infante‐Garcia, C., Zopeque-Garcia, N., Lechuga-Sancho, A. M., & Garcı́a-Alloza, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.005 · Cited by 60 · see citing works
Rising Midlife Obesity Will Worsen Future Prevalence of Dementia
Nepal, B., Brown, L., & Anstey, K. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099305 · Cited by 54 · see citing works
High‐fat diet protects the blood–brain barrier in an Alzheimer's disease mouse model
Goldman, S. E., Goez, D., Last, D., Naor, S., Zaltsman, S. L., Sharvit‐Ginon, I., Atrakchi, D., Shemesh, C., Twitto‐Greenberg, R., Tsach, S., et al. (2018) · Aging Cell · doi:10.1111/acel.12818 · Cited by 50 · see citing works
Salas, I. H., Weerasekera, A., Ahmed, T., Callaerts‐Vegh, Z., Himmelreich, U., D’Hooge, R., Balschun, D., Saido, T. C., Strooper, B. D., & Dotti, C. G. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.001 · Cited by 45 · see citing works
Maesako, M., Uemura, M. T., Tashiro, Y., Sasaki, K., Watanabe, K., Noda, Y., Ueda, K., Asada‐Utsugi, M., Kubota, M., Okawa, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131199 · Cited by 44 · see citing works
Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology
Su, M., Nadéri, K., Samson-Desvignes, N., Youssef, I., Fülöp, L., Bozsó, Z., Laroche, S., Delatour, B., & Davis, S. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1475-8 · Cited by 43 · see citing works
Cifre, M., Palou, A., & Oliver, P. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0246-8 · Cited by 40 · see citing works
Zhang, Y., Yin, F., Liu, J., & Liu, Z. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12673 · Cited by 34 · see citing works
Vascular risk factors and dementia revisited
Debette, S., & Seshadri, S. S. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.181289 · Cited by 17 · see citing works
Ruiz‐Uribe, N. E., & Bracko, O. (2020) · doi:10.21203/rs.3.pex-838/v1 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [48]Carpentier Giles, H. E. Dot Blot Analyzer: Software development using the macro language of ImageJ. Proceedings of the ImageJ User and Developer Conference pp. 3-5-189 (2008).
Cited by
Sorted by citations
The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works
Inflammation context in Alzheimer’s disease, a relationship intricate to define
Novoa, C., Salazar, P., Cisternas, P., Gherardelli, C., Vera-Salazar, R., Zolezzi, J. M., & Inestrosa, N. C. (2022) · Biological Research · doi:10.1186/s40659-022-00404-3 · Cited by 206 · see citing works
Inkpen, K., Chappidi, S., Mallari, K., Nushi, B., Ramesh, D., Michelucci, P., Mandava, V., Vepřek, L. H., & Quinn, G. (2023) · ACM Transactions on Computer-Human Interaction · doi:10.1145/3534561 · Cited by 132 · see citing works
Self-citationGannon, O. J., Robison, L. S., Salinero, A. E., Abi-Ghanem, C., Mansour, F. M., Kelly, R. D., Tyagi, A., Brawley, R. R., Ogg, J. D., & Zuloaga, K. L. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02466-2 · Cited by 127 · see citing works
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease
Bracko, O., Hernández, J. C. C., Park, L., Nishimura, N., & Schaffer, C. B. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20982383 · Cited by 122 · see citing works
Self-citationVinuesa, Á., Pomilio, C. J., Gregosa, A., Bentivegna, M., Presa, J., Bellotto, M., Saravia, F., & Beauquis, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.653651 · Cited by 111 · see citing works
The complex relationship between obesity and neurodegenerative diseases: an updated review
Neto, A., Fernandes, A. M. A., & Barateiro, A. P. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1294420 · Cited by 113 · see citing works
3D convolutional neural networks for stalled brain capillary detection
Solovyev, R. A., Kalinin, A. A., & Gabruseva, T. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.105089 · Cited by 95 · see citing works
Ali, M., Falkenhain, K., Njiru, B. N., Murtaza-Ali, M., Ruiz‐Uribe, N. E., Haft‐Javaherian, M., Catchers, S., Nishimura, N., Schaffer, C. B., & Bracko, O. (2021) · Brain · doi:10.1093/brain/awab387 · Cited by 97 · see citing works
Self-citationRobison, L. S., Gannon, O. J., Thomas, M. A., Salinero, A. E., Abi‐Ghanem, C., Poitelon, Y., Belin, S., & Zuloaga, K. L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01956-5 · Cited by 78 · see citing works
Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview
Bem, A. F. D., Krolow, R., Farias, H. R., de Rezende, V. L., Gelain, D. P., Moreira, J. C. F., Duarte, J. M. N., & de Oliveira, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.604150 · Cited by 64 · see citing works
Sharma, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113528 · Cited by 65 · see citing works
Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61 · see citing works
Dunk, M. M., Li, J., Liu, S., Casanova, R., Chen, J., Espeland, M. A., Hayden, K. M., Manson, J. E., Rapp, S. R., Shadyab, A. H., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13358 · Cited by 53 · see citing works
Zhou, R., Chen, L., Yang, H., Li, L., Liu, J., Chen, L., Hong, W., Wang, C., Ma, J., Huang, J., et al. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210906092940 · Cited by 44 · see citing works
Mazzei, G., Ikegami, R., Abolhassani, N., Haruyama, N., Sakumi, K., Saito, T., Saido, T. C., & Nakabeppu, Y. (2021) · Aging Cell · doi:10.1111/acel.13429 · Cited by 40 · see citing works
The effect of dietary fat consumption on Alzheimer’s disease pathogenesis in mouse models
Amelianchik, A., Sweetland-Martin, L., & Norris, E. H. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02067-w · Cited by 43 · see citing works
Reveglia, P., Paolillo, C., Ferretti, G., Carlo, A. D., Angiolillo, A., Nasso, R., Caputo, M., Matrone, C., Costanzo, A. D., & Corso, G. (2021) · Metabolomics · doi:10.1007/s11306-021-01828-w · Cited by 39 · see citing works
Valentin‐Escalera, J., Leclerc, M., & Calon, F. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230118 · Cited by 35 · see citing works
Chen, P., Chen, F., Lei, J., Wang, G., & Zhou, B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.768097 · Cited by 36 · see citing works
Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques
Natunen, T., Martiskainen, H., Marttinen, M., Gabbouj, S., Koivisto, H., Kemppainen, S., Kaipainen, S., Takalo, M., Svobodová, H., Leppänen, L., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00415-2 · Cited by 34 · see citing works
Mapping Citizen Science through the Lens of Human-Centered AI
Rafner, J. F., Gajdacz, M., Kragh, G., Hjorth, A., Gander, A. J., Palfi, B., Berditchevskiaia, A., Grey, F., Gal, K., Segal, A., et al. (2022) · Human Computation · doi:10.15346/hc.v9i1.133 · Cited by 32 · see citing works
Self-citationYavari, M., Kalupahana, N. S., Harris, B. N., Ramalingam, L., Zu, Y., Kahathuduwa, C. N., & Moustaïd‐Moussa, N. (2025) · Nutrients · doi:10.3390/nu17071203 · Cited by 29 · see citing works
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells
Schaible, P., Henschel, J., & Erny, D. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03371-0 · Cited by 31 · see citing works
Haft‐Javaherian, M., Villiger, M., Schaffer, C. B., Nishimura, N., Golland, P., & Bouma, B. E. (2020) · IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) · doi:10.1109/cvprw50498.2020.00503 · Cited by 26 · see citing works
Self-citationImpact of Genetic Risk Factors for Alzheimer’s Disease on Brain Glucose Metabolism
Cho, S., Lee, H., & Seo, J. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02297-x · Cited by 25 · see citing works
Sferra, R., Pompili, S., Cappariello, A., Gaudio, E., Latella, G., & Vetuschi, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147280 · Cited by 25 · see citing works
Oblak, A. L., Kotredes, K. P., Pandey, R. S., Reagan, A. M., Ingraham, C., Perkins, B., Lloyd, C., Baker, D., Lin, P. B., Soni, D. M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.886575 · Cited by 23 · see citing works
“Also, the addition of a HFD exacerbated AD phenotypes in mouse models relevant to early-onset AD[21-25].”
BackgroundAmelianchik, A., Merkel, J., Palanisamy, P., Kaneki, S., Feierman, E. R., & Norris, E. H. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12173 · Cited by 21 · see citing works
Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice
Lee, Y., Park, H. R., Lee, J. Y., Kim, J., Yang, S., Lee, C., Kim, H. S., Kim, H. S., Chang, S., & Lee, J. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01440-7 · Cited by 22 · see citing works
So, S. W., Fleming, K. M., Nixon, J. P., & Butterick, T. A. (2023) · Nutrients · doi:10.3390/nu15112494 · Cited by 22 · see citing works
Lim, H., Bae, S., Han, K., Kang, B., Jeong, Y., Kim, S., & Suh, M. (2022) · iScience · doi:10.1016/j.isci.2023.106655 · Cited by 20 · see citing works
Saiyasit, N., Butlig, E.-A. R., Chaney, S. D., Traylor, M. K., Hawley, N. A., Randall, R. B., Bobinger, H. V., Frizell, C. A., Trimm, F., Crook, E. D., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.915405 · Cited by 21 · see citing works
Ali, M. A., Falkenhain, K., Njiru, B. N., Murtaza-Ali, M., Ruiz‐Uribe, N. E., Haft‐Javaherian, M., Catchers, S., Nishimura, N., Schaffer, C. B., & Bracko, O. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.05.433976 · Cited by 19 · see citing works
Self-citationMengr, A., Strnadová, V., Strnad, Š., Vrkoslav, V., Pelantová, H., Kuzma, M., Comptdaer, T., Železná, B., Kuneš, J., Galas, M., et al. (2023) · Nutrients · doi:10.3390/nu15173690 · Cited by 17 · see citing works
Kunevičius, A., Vijaya, A. K., Atzeni, A., Mingaila, J., Šimoliūnė, I., Jamontas, R., Kezeviciute, E., Gueimonde, M., Meškys, R., Baltriukienė, D., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1617980 · Cited by 16 · see citing works
Ibeh, S., Bakkar, N. Z., Ahmad, F. A., Nwaiwu, J. I., Barsa, C., Mekhjian, S., Reslan, M. A., Eid, A. H., Harati, H., Nabha, S. M., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121316 · Cited by 15 · see citing works
Zhou, J., Tang, M., Li, W., Fang, R., Tang, C., & Wang, Q. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250049 · Cited by 15 · see citing works
Moyamoya disease: A human model for chronic hypoperfusion and intervention in Alzheimer's disease
Zou, X., Yuan, Y., Liao, Y., Jiang, C., Zhao, F., Ding, D., Gu, Y., Chen, L., Chu, Y., Hsu, Y., et al. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12285 · Cited by 12 · see citing works
Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison
Goikolea, J., Latorre‐Leal, M., Tsagkogianni, C., Pikkupeura, S., Gulyás, B. Z., Cedazo-Mı́nguez, Á., Loera‐Valencia, R., Björkhem, I., Rodriguez‐Rodriguez, P., & Maioli, S. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106387 · Cited by 13 · see citing works
Mackey-Alfonso, S. E., & Barrientos, R. M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70911 · Cited by 13 · see citing works
Bah, T. M., Allen, E. M., García‐Jaramillo, M., Perez, R., Zarnegarnia, Y., Davis, C. M., Bloom, M. B., Magaña, A. A., Choi, J., Bobe, G., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.893030 · Cited by 11 · see citing works
Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer’s model
Allerton, T. D., Stampley, J., Li, Z., Yu, X., Quiariate, H., Doiron, J. E., White, G., Wigger, Z., Gartia, M. R., Lefer, D. J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-75870-8 · Cited by 10 · see citing works
Jain, A., & Roy, P. (2023) · Chaos, Solitons & Fractals · doi:10.1016/j.chaos.2022.112902 · Cited by 9 · see citing works
Ruiz‐Uribe, N. E., Bracko, O., Swallow, M. A., Omurzakov, A., Dash, S., Uchida, H., Xiang, D., Haft‐Javaherian, M., Falkenhain, K., Lamont, M. R. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.15.528710 · Cited by 10 · see citing works
Self-citationHypercholesterolemia drives microglial dysfunction and weakens response to amyloid plaques
Kaye, S. D., Gold, A., Lin, D., Chen, M., Zhu, J., & Gao, J. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115272 · Cited by 11 · see citing works
Yavari, M., Ramalingam, L., Harris, B. N., Kahathuduwa, C. N., Chavira, A., Biltz, C., Mounce, L., Maldonado, K. A., Scoggin, S. O., Zu, Y., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.030 · Cited by 8 · see citing works
Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease
Tabrizi, Z., Lim, X. R., Chakraborty, S., Harraz, O. F., & Bracko, O. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.71016 · Cited by 8 · see citing works
Self-citationEffects of Menopause and High Fat Diet on Metabolic Outcomes in a Mouse Model of Alzheimer’s Disease
Abi‐Ghanem, C., Salinero, A. E., Smith, R. M., Kelly, R. D., Belanger, K., Richard, R., Paul, A. S., Herzog, A. A., Thrasher, C. A., Rybka, K. A., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231332 · Cited by 6 · see citing works
Abi‐Ghanem, C., Kelly, R. D., Groom, E., Valerian, C. G., Paul, A. S., Thrasher, C. A., Salinero, A. E., Batchelder, M. R., Lafrican, J. J., Wang, M.-X., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70026 · Cited by 6 · see citing works
Lippi, S. L. P., Barkey, R. E., & Rodriguez, M. N. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114316 · Cited by 6 · see citing works
Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice
Babalola, J. A., Stracke, A., Loeffler, T., Schilcher, I., Sideromenos, S., Flunkert, S., Neddens, J., Lignell, Å., Prokesch, M., Pazenboeck, U., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101959 · Cited by 5 · see citing works
Abi, I., Ashiekaa, M. T., Abi, E., Adeniyi, O. S., & Saalu, L. C. (2022) · Advances in Alzheimer s Disease · doi:10.4236/aad.2022.111001 · Cited by 5 · see citing works
Ormazabal, P., Gherardelli, C., Pinto, C., Servili, E., Méndez‐Orellana, C., Wong, G. W., Contreras, R., Cisternas, P., & Inestrosa, N. C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110607 · Cited by 4 · see citing works
Targett, I. L., Hancock, J. T., & Craig, T. J. (2026) · Biomedicines · doi:10.3390/biomedicines14051089 · Cited by 4 · see citing works
Almanza, D. L., Koletar, M. M., Lai, A. Y., Lam, W. W., Joo, I. L., Hill, M. E., Stanisz, G. J., McLaurin, J., & Stefanovic, B. (2024) · Theranostics · doi:10.7150/thno.98793 · Cited by 4 · see citing works
Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease
Doroszkiewicz, J., Mroczko, J., Rutkowski, P., & Mroczko, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310751 · Cited by 4 · see citing works
Lai, A. Y., Almanza, D. L., Ribeiro, J. A., Hill, M. E., Mandrozos, M., Koletar, M. M., Stefanovic, B., & McLaurin, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.11.575200 · Cited by 4 · see citing works
Gokulan, K., Karn, K., Sarkar, S., Raymick, J. B., & Khare, S. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251358414 · Cited by 3 · see citing works
Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila
Singh, M. K., Ryu, T. H., Nguyet, N. M., & Yu, K. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150446 · Cited by 3 · see citing works
Wang, D., Irewole, E. A., Bays, L. D., Smith, M. D., & Schreurs, B. G. (2025) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2025.108053 · Cited by 3 · see citing works
A high fat diet potentiates neonatal iron overload-induced memory impairments in rats
do Nascimento, F. V., de Freitas, B. S., dos Passos, M. P., Kleverston, L., dos Santos, C. D. S., Kist, L. W., Bogo, M. R., Bromberg, E., & Schröder, N. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03333-x · Cited by 3 · see citing works
Cholesterol and obesity: A marker for Alzheimer’s disease
Sumithra, M., & Ancy, P. M. (2022) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2022.11.1.27 · Cited by 3 · see citing works
From plant to brain: flavonoids in the management of obesity-associated cognitive dysfunction
Berilli, P., Berni, P. R. D. A., Zandoná, L. R., Bellinazzi, L. N., & Maróstica, M. R. (2025) · Nutrition Research Reviews · doi:10.1017/s0954422425100085 · Cited by 2 · see citing works
Neurology Evaluation in Dementia and Neurodegenerative Disease
Giliberto, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-82367-2_20 · Cited by 2 · see citing works
Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice
Kelliny, S., Deng, I. B., Zhou, X., & Bobrovskaya, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89833-1.00026-4 · Cited by 2 · see citing works
High‐caloric intake rescues early symptomatic AD‐induced hippocampal neurovascular coupling deficits
Almanza, D. L., Trevisiol, A., Koletar, M. M., Lai, A. Y., Ribeiro, J. A., Hill, M. E., Stanisz, G. J., McLaurin, J., & Stefanovic, B. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70708 · Cited by 1 · see citing works
High-fat diet impairs intermediate-term memory by autophagic-lysosomal dysfunction in Drosophila
Tong, Y. A., Jiang, M., Onuki, K., Itoh, M., & Tonoki, A. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011818 · Cited by 1 · see citing works
Ahn, S.-J., Goya, B., Bertomo, C., Sciortino, R. K., Racchumi, G., García‐Bonilla, L., Anrather, J., Iadecola, C., & Faraco, G. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf217 · Cited by 1 · see citing works
Sabourin, S., Thrasher, C. A., Smith, R. M., Belanger, K., Thibodeau, B., Abi‐Ghanem, C., Lafrican, J. J., Camon, C., Kelly, R. D., Richard, R., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03719-0 · Cited by 1 · see citing works
A systematic review on the effects of hypercaloric diet in animal models of Alzheimer's disease
Carbone, E., Scibetta, S., Cappella, M., Crestini, A., Perrone, F., Hallulli, M., Rosa, P., Rivabene, R., Maiolo, F., Simonelli, V., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261448495 · Cited by 1 · see citing works
Njoku, G. C., & Saraswathi, V. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1837438 · Cited by 1 · see citing works
Unhealthy dietary patterns and Alzheimer’s disease: associations and underlying mechanistic pathways
Ramasinghe, C., & Xu, B. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2691237 · Cited by 1 · see citing works
Food for Memory: A Review of the Effects of Diet on Alzheimer's Disease Progression
Krishnan, A., & Katchur, N. J. (2021) · Journal of Student Research · doi:10.47611/jsrhs.v10i4.2320 · Cited by 1 · see citing works
Shukla, A., Meena, K., Gupta, A. K., & Sandhir, R. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00510 · Cited by 1 · see citing works
Role of Animal Models in Alzheimer’s Disease Drug Development
Kinney, J. W., Osse, A. M. L., Lamb, B. T., Oblack, A., Palkowitz, A. D., & Belas, F. J. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108975759.008
Dietary saturated and unsaturated fatty acids and peripheral neuropathy
Savelieff, M. G., Kim, B., Rumora, A. E., & Feldman, E. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89834-8.00033-7
Rodriguez, S., Thiruchelvi, R., Thenmozhi, A. J., Cosio, D. S., Shamaladevi, N., Hussain, H., Natarajan, S., Paidas, M. J., & Jayakumar, A. R. (2023) · Nutritional neurosciences · doi:10.1007/978-981-99-0677-2_5
Obesity Improves Neuronal Metabolism and Functional Hyperemia in a Rat Model of Early Ad PathologyPreprint
Almanza, D. L., Koletar, M. M., Lai, A. Y., Lam, W. W., Joo, I. L., Hill, M. E., Stanisz, G. J., McLaurin, J., & Stefanovic, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3911864/v1
Machine learning-based method to detect capillary stalling using optical coherence tomography
Assi, J. Y., Stefan, S., Tang, R. P., Küreli, G., Kura, S., Long, E., Jiang, J., Boas, D. A., & Lee, J. (2025) · Biomedical Optics Express · doi:10.1364/boe.558490
Robison, L. S., Gannon, O. J., Thomas, M. A., Salinero, A. E., Abi‐Ghanem, C., Poitelon, Y., Belin, S., & Zuloaga, K. L. (2020) · Figshare · doi:10.6084/m9.figshare.13023537
Chang, S. N., Guttula, P. K., Agrawal, K., Sheikh, E., Beavers, W. N., Allerton, T. D., & Gartia, M. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.14.725257
Impact of High Dietary Salt on Neurovascular and Cognitive Functions
Faraco, G. (2026) · Hypertension · doi:10.1161/hypertensionaha.126.26772
Mechanistic link of obesity to depression and cognitive decline in Alzheimer’s disease
Kusi‐Mensah, K., Jones, N., Haroon, H., Veldić, M., & Choi, D. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106979
- Authors
- Bracko, O., Vinarcsik, L. K., Cruz Hernández, J. C., Ruiz-Uribe, N. E., Haft-Javaherian, M., Falkenhain, K., Ramanauskaite, E. M., Ali, M., Mohapatra, A., Swallow, M. A., Njiru, B. N., Muse, V., Michelucci, P. E., Nishimura, N., & Schaffer, C. B.
- Affiliations
- Cornell University (US)
- Human Computation Institute (US)
- Corresponding author
- Schaffer, Chris B.
- ORCID
- Venue
- Scientific Reports
- Published
- 2020-06-18
- Volume
- 10
- Issue
- 1
- Pages
- 9884-9884
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7303150
- OpenAlex
- W3035923503
- Cited by
- 85
- References
- 70
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 18 · 2020: 4
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation
- BrightFocus Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (1s10rr025502-01, AG049952)
- National Institute on Aging (RF1AG049952, R01AG049952)
- National Institute of Neurological Disorders and Stroke (R01NS108472)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, high-fat diet, obesity, APP/PS1 mice, cerebral blood flow, neutrophil adhesion, amyloid plaques, neuroinflammation, memory impairment, social interaction, sensorimotor function, vascular inflammation
- MeSH terms
- Alzheimer Disease, Animals, Behavior, Animal, Blood Vessels, Cerebrovascular Circulation, Disease Models, Animal, Female, Genotype, Male, Memory, Short-Term, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Cytokines, Amyloid beta-Protein Precursor, Mice, Presenilin-1, Diet, High-Fat
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