Boutros, Michael

Wnt signaling in cancer

Zhan, T., Rindtorff, N., & Boutros, M. (2017) · Oncogene

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

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A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 1,240

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

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Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein

Bartscherer, K., Pelte, N., Ingelfinger, D., & Boutros, M. (2006) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 580

Dishevelled: at the crossroads of divergent intracellular signaling pathways

Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 275

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Michels, B. E., Mosa, M. H., Streibl, B. I., Zhan, T., Menche, C., Abou-El-Ardat, K., Darvishi, T., Członka, E., Wagner, S., Winter, J., et al. (2020) · Cell Stem Cell

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

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Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

Horn, T., Sandmann, T., Fischer, B., Axelsson, E., Huber, W., & Boutros, M. (2011) · Nature Methods

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 193

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Zhan, T., Ambrosi, G., Wandmacher, A. M., Rauscher, B., Betge, J., Rindtorff, N., Häussler, R. S., Hinsenkamp, I., Bamberg, L., Hessling, B., et al. (2019) · Nature Communications

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

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A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

Guida, C., Altamura, S., Klein, F. A., Galy, B., Boutros, M., Ulmer, A. J., Hentze, M. W., & Muckenthaler, M. U. (2015) · Blood

Iron Metabolism and DisordersImmune Response and Inflammation

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The organoid cell atlas

the Human Cell Atlas ‘Biological Network’ Organoids, Bock, C., Boutros, M., Camp, J. G., Clarke, L., Clevers, H., Knoblich, J. A., Liberali, P., Regev, A., Rios, A. C., et al. (2021) · Nature Biotechnology

Single-cell and spatial transcriptomicsPluripotent Stem Cells Research

Cited by 171

RNA Interference (RNAi) Screening in Drosophila

Heigwer, F., Port, F., & Boutros, M. (2018) · Genetics

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 125

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

Leibing, T., Géraud, C., Augustin, I., Boutros, M., Augustin, H. G., Okun, J. G., Langhans, C., Zierow, J., Wohlfeil, S. A., Olsavszky, V., et al. (2018) · Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

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A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver

Inverso, D., Shi, J., Lee, K. H., Jakab, M., Ben-Moshe, S., Kulkarni, S. R., Schneider, M., Wang, G., Komeili, M., Vélez, P. A., et al. (2021) · Developmental Cell

Single-cell and spatial transcriptomicsLiver physiology and pathology

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Artificial intelligence for detection of microsatellite instability in colorectal cancer—a multicentric analysis of a pre-screening tool for clinical application

Echle, A., Ghaffari Laleh, N., Quirke, P., Grabsch, H. I., Muti, H. S., Saldanha, O. L., Brockmoeller, S. F., van den Brandt, P. A., Hutchins, G. G. A., Richman, S. D., et al. (2022) · ESMO Open

AI in cancer detectionGenetic factors in colorectal cancer

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Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

Mleczko-Sanecka, K., Roche, F., Rita da Silva, A., Call, D., D’Alessio, F., Ragab, A., Lapinski, P. E., Ummanni, R., Korf, U., Oakes, C., et al. (2014) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

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Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

Funk, M. C., Gleixner, J. G., Heigwer, F., Valentini, E., Aydin, Z., Tonin, E., Hetzer, J., Heide, D., Stegle, O., Heikenwalder, M., et al. (2021) · Developmental Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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