Rosenbauer, Frank

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,457

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell

interferon and immune responsesImmunodeficiency and Autoimmune Disorders

Cited by 644

Transcription factors in myeloid development: balancing differentiation with transformation

Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 606

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Rosenbauer, F., Wagner, K., Kutok, J. L., Iwasaki, H., Le Beau, M. M., Okuno, Y., Akashi, K., Fiering, S., & Tenen, D. G. (2004) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 506

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Bröske, A.-M., Vockentanz, L., Kharazi, S., Huska, M. R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., et al. (2009) · Nature Genetics

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 478

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

Gerlach, K., Hwang, Y., Nikolaev, A., Atreya, R., Dornhoff, H., Steiner, S., Lehr, H.-A., Wirtz, S., Vieth, M., Waisman, A., et al. (2014) · Nature Immunology

Inflammatory Bowel DiseaseT-cell and B-cell Immunology

Cited by 407

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 237

Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias

Schmidt, M., Nagel, S., Proba, J., Thiede, C., Ritter, M., Waring, J. F., Rosenbauer, F., Huhn, D., Wittig, B., Horak, I., et al. (1998) · Blood

Acute Myeloid Leukemia ResearchChronic Myeloid Leukemia Treatments

Cited by 199

Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells

Steidl, U., Rosenbauer, F., Verhaak, R. G. W., Gu, X., Ebralidze, A., Otu, H. H., Klippel, S., Steidl, C., Bruns, I., Costa, D. B., et al. (2006) · Nature Genetics

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 184

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

Okuno, Y., Huang, G., Rosenbauer, F., Evans, E. K., Radomska, H. S., Iwasaki, H., Akashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., et al. (2005) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 174

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

Staber, P. B., Zhang, P., Ye, M., Welner, R. S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B. A., Zhang, H., Alberich-Jordà, M., et al. (2013) · Molecular Cell

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 158

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N. K., Follows, G., Schönheit, J., Vockentanz, L., et al. (2011) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 131

PU.1 Level-Directed Chromatin Structure Remodeling at the Irf8 Gene Drives Dendritic Cell Commitment

Schönheit, J., Kuhl, C., Gebhardt, M. L., Klett, F. F., Riemke, P., Scheller, M., Huang, G., Naumann, R., Leutz, A., Stocking, C., et al. (2013) · Cell Reports

Genomics and Chromatin DynamicsImmunotherapy and Immune Responses

Cited by 127

Macrophage development from HSCs requires PU.1-coordinated microRNA expression

Ghani, S., Riemke, P., Schönheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A., Heinz, S., Bonifer, C., Bakkers, J., et al. (2011) · Blood

Hematopoietic Stem Cell TransplantationMicroRNA in disease regulation

Cited by 123

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia

Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.-J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., et al. (2007) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 114

Interferon Consensus Sequence Binding Protein and Interferon Regulatory Factor-4/Pip Form a Complex That Represses the Expression of the Interferon-Stimulated Gene-15 in Macrophages

Rosenbauer, F., Waring, J. F., Foerster, J., Wietstruk, M., Philipp, D., & Horak, I. (1999) · Blood

interferon and immune responsesImmune Response and Inflammation

Cited by 76

Role of Transcription Factors C/EBPa and PU.1 in Normal Hematopoiesis and Leukemia

Koschmieder, S., Rosenbauer, F., Steidl, U., Owens, B. M., & Tenen, D. G. (2005) · International Journal of Hematology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 72

Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy

Wagner, K., Zhang, P., Rosenbauer, F., Drescher, B., Kobayashi, S., Radomska, H. S., Kutok, J. L., Gilliland, D. G., Krauter, J., & Tenen, D. G. (2006) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchChronic Myeloid Leukemia Treatments

Cited by 66

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow

Susek, K. H., Korpos, E., Huppert, J., Wu, C., Savelyeva, I., Rosenbauer, F., Müller-Tidow, C., Koschmieder, S., & Sorokin, L. (2018) · Matrix Biology

Hematopoietic Stem Cell TransplantationCell Adhesion Molecules Research

Cited by 58

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils

Fischer, J., Walter, C., Tönges, A., Aleth, H., Jordão, M. J. C., Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., et al. (2019) · Nature Immunology

Neutrophil, Myeloperoxidase and Oxidative MechanismsGenomics and Chromatin Dynamics

Cited by 56

HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia

Gregoricchio, S., Polit, L., Esposito, M., Berthelet, J., Delestré, L., Evanno, E., Diop, M., Gallais, I., Aleth, H., Poplineau, M., et al. (2022) · Nucleic Acids Research

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 27

PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells

Gerlach, K., Popp, V., Wirtz, S., Al-Saifi, R., Gonzalez Acera, M., Atreya, R., Dregelies, T., Vieth, M., Fichtner-Feigl, S., McKenzie, A. N. J., et al. (2022) · Journal of Crohn's and Colitis

T-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

Cited by 25