Maecker, Holden T.

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Arunachalam, P. S., Wimmers, F., Mok, C. K. P., Perera, R. A. P. M., Scott, M., Hagan, T., Sigal, N., Feng, Y., Bristow, L., Tak-Yin Tsang, O., et al. (2020) · Science

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 1,186

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell

Genetic Associations and EpidemiologyImmune responses and vaccinations

Cited by 1,065

mTOR inhibition improves immune function in the elderly

Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine

Genetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

Cited by 786

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 572

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 513

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 477

Cytomegalovirus infection enhances the immune response to influenza

Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 332

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis

Zhu, H., Galdos, F. X., Lee, D., Waliany, S., Huang, Y. V., Ryan, J., Dang, K., Neal, J. W., Wakelee, H. A., Reddy, S. A., et al. (2022) · Circulation

Cancer Immunotherapy and BiomarkersViral Infections and Immunology Research

Cited by 192

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients

Subrahmanyam, P. B., Dong, Z., Gusenleitner, D., Giobbie-Hurder, A., Severgnini, M., Zhou, J., Manos, M., Eastman, L. M., Maecker, H. T., & Hodi, F. S. (2018) · Journal for ImmunoTherapy of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 190

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

Furman, D., Jojic, V., Kidd, B., Shen‐Orr, S., Price, J., Jarrell, J., Tse, T., Huang, H., Lund, P., Maecker, H. T., et al. (2013) · Molecular Systems Biology

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 184

A model for harmonizing flow cytometry in clinical trials

the FOCIS Human Immunophenotyping Consortium, Maecker, H. T., & McCoy, J. P. (2010) · Nature Immunology

Clinical Laboratory Practices and Quality ControlT-cell and B-cell Immunology

Cited by 155

Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans

Shen-Orr, S. S., Furman, D., Kidd, B. A., Hadad, F., Lovelace, P., Huang, Y.-W., Rosenberg-Hasson, Y., Mackey, S., Grisar, F. A. G., Pickman, Y., et al. (2016) · Cell Systems

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 154

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

Hartmann, F. J., Babdor, J., Gherardini, P. F., Amir, E.-A. D., Jones, K., Sahaf, B., Marquez, D. M., Krutzik, P., O’Donnell, E., Sigal, N., et al. (2019) · Cell Reports

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 124

New tools for classification and monitoring of autoimmune diseases

Maecker, H. T., Lindstrom, T. M., Robinson, W. H., Utz, P. J., Hale, M., Boyd, S. D., Shen-Orr, S. S., & Fathman, C. G. (2012) · Nature Reviews Rheumatology

Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus Research

Cited by 95

Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents

Ho, T. C., Teresi, G. I., Segarra, J. R., Ojha, A., Walker, J. C., Gu, M., Spielman, D. M., Sacchet, M. D., Jiang, F., Rosenberg-Hasson, Y., et al. (2021) · Frontiers in Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 32