Sunyaev, Shamil R.

A universal trend of amino acid gain and loss in protein evolution

Jordan, I. K., Kondrashov, F. A., Adzhubei, I. A., Wolf, Y. I., Koonin, E. V., Kondrashov, A. S., & Sunyaev, S. (2005) · Nature

RNA and protein synthesis mechanismsEvolution and Genetic Dynamics

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Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

Chun, S., Casparino, A., Patsopoulos, N. A., Croteau-Chonka, D. C., Raby, B. A., De Jager, P. L., Sunyaev, S. R., & Cotsapas, C. (2017) · Nature Genetics

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 259

The landscape of tolerated genetic variation in humans and primates

Gao, H., Hamp, T., Ede, J., Schraiber, J. G., McRae, J., Singer-Berk, M., Yang, Y., Dietrich, A., Fiziev, P., Kuderna, L., et al. (2023) · Science

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 183

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Schoech, A. P., Jordan, D. M., Loh, P.-R., Gazal, S., O’Connor, L. J., Balick, D. J., Palamara, P. F., Finucane, H. K., Sunyaev, S. R., & Price, A. L. (2019) · Nature Communications

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 157

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

Gazal, S., Loh, P.-R., Finucane, H. K., Ganna, A., Schoech, A., Sunyaev, S., & Price, A. L. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 154

Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans

Cade, B. E., Chen, H., Stilp, A. M., Gleason, K. J., Sofer, T., Ancoli-Israel, S., Arens, R., Bell, G. I., Below, J. E., Bjonnes, A. C., et al. (2016) · American Journal of Respiratory and Critical Care Medicine

Obstructive Sleep Apnea ResearchGenetic Associations and Epidemiology

Cited by 134

Population-specific causal disease effect sizes in functionally important regions impacted by selection

Shi, H., Gazal, S., Kanai, M., Koch, E. M., Schoech, A. P., Siewert, K. M., Kim, S. S., Luo, Y., Amariuta, T., Huang, H., et al. (2021) · Nature Communications

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 119

Identification of cis-suppression of human disease mutations by comparative genomics

Task Force for Neonatal Genomics, Jordan, D. M., Frangakis, S. G., Golzio, C., Cassa, C. A., Kurtzberg, J., Davis, E. E., Sunyaev, S. R., & Katsanis, N. (2015) · Nature

Genomics and Rare DiseasesGenomics and Phylogenetic Studies

Cited by 115

Calibration of Multiple In Silico Tools for Predicting Pathogenicity of Mismatch Repair Gene Missense Substitutions

Thompson, B. A., Greenblatt, M. S., Vallee, M. P., Herkert, J. C., Tessereau, C., Young, E. L., Adzhubey, I. A., Li, B., Bell, R., Feng, B., et al. (2013) · Human Mutation

Genomics and Rare DiseasesGenetic factors in colorectal cancer

Cited by 95

Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea–related Quantitative Trait Locus in Men

Chen, H., Cade, B. E., Gleason, K. J., Bjonnes, A. C., Stilp, A. M., Sofer, T., Conomos, M. P., Ancoli-Israel, S., Arens, R., Azarbarzin, A., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology

Obstructive Sleep Apnea ResearchGenetic Associations and Epidemiology

Cited by 82

Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

Kiezun, A., Pulit, S. L., Francioli, L. C., van Dijk, F., Swertz, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., van Ommen, G. J. B., Wijmenga, C., et al. (2013) · PLoS Genetics

Evolution and Genetic DynamicsGenomics and Rare Diseases

Cited by 72

Quantifying constraint in the human mitochondrial genome

Lake, N. J., Liu, W., Battle, S. L., Laricchia, K. M., Tiao, G., Puiu, D., Compton, A. G., Cowie, S., Christodoulou, J., Thorburn, D. R., et al. (2022) · Nature

Genomics and Rare DiseasesMitochondrial Function and Pathology

Cited by 63

Quantifying constraint in the human mitochondrial genome

Lake, N. J., Ma, K., Liu, W., Battle, S. L., Laricchia, K. M., Tiao, G., Puiu, D., Ng, K. K., Cohen, J., Compton, A. G., et al. (2024) · Nature

Genomics and Rare DiseasesMitochondrial Function and Pathology

Cited by 63

Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans

Wang, H., Cade, B. E., Sofer, T., Sands, S. A., Chen, H., Browning, S. R., Stilp, A. M., Louie, T. L., Thornton, T. A., Johnson, W. C., et al. (2019) · Human Molecular Genetics

Obstructive Sleep Apnea ResearchGenetic Associations and Epidemiology

Cited by 56

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

Cade, B. E., Chen, H., Stilp, A. M., Louie, T., Ancoli-Israel, S., Arens, R., Barfield, R., Below, J. E., Cai, J., Conomos, M. P., et al. (2019) · PLOS Genetics

Obstructive Sleep Apnea ResearchGenetic Associations and Epidemiology

Cited by 39

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Cade, B. E., Lee, J., Sofer, T., Wang, H., Zhang, M., Chen, H., Gharib, S. A., Gottlieb, D. J., Guo, X., Lane, J. M., et al. (2021) · Genome Medicine

Obstructive Sleep Apnea ResearchGenetic Associations and Epidemiology

Cited by 33

Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases

Kobren, S. N., Baldridge, D., Velinder, M., Krier, J. B., LeBlanc, K., Esteves, C., Pusey, B. N., Züchner, S., Blue, E., Lee, H., et al. (2021) · Genetics in Medicine

Genomics and Rare DiseasesGenomics and Phylogenetic Studies

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