Damm, Georg

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Multilineage communication regulates human liver bud development from pluripotency

Camp, J. G., Sekine, K., Gerber, T., Loeffler-Wirth, H., Binder, H., Gac, M., Kanton, S., Kageyama, J., Damm, G., Seehofer, D., et al. (2017) · Nature

Pluripotent Stem Cells ResearchLiver physiology and pathology

Cited by 621

Cell sources for in vitro human liver cell culture models

Zeilinger, K., Freyer, N., Damm, G., Seehofer, D., & Knöspel, F. (2016) · Experimental Biology and Medicine

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 230

Manufactured nanomaterials: categorization and approaches to hazard assessment

Gebel, T., Foth, H., Damm, G., Freyberger, A., Kramer, P.-J., Lilienblum, W., Röhl, C., Schupp, T., Weiss, C., Wollin, K.-M., et al. (2014) · Archives of Toxicology

Nanoparticles: synthesis and applicationsGraphene and Nanomaterials Applications

Cited by 137

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

Brosch, M., Kattler, K., Herrmann, A., von Schönfels, W., Nordström, K., Seehofer, D., Damm, G., Becker, T., Zeissig, S., Nehring, S., et al. (2018) · Nature Communications

Epigenetics and DNA MethylationLiver physiology and pathology

Cited by 98

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

Mleczko-Sanecka, K., Roche, F., Rita da Silva, A., Call, D., D’Alessio, F., Ragab, A., Lapinski, P. E., Ummanni, R., Korf, U., Oakes, C., et al. (2014) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 74

Diploid hepatocytes drive physiological liver renewal in adult humans

Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lázár, E., Feddema, J., Welsch, T., Alkass, K., Salehpour, M., et al. (2022) · Cell Systems

Liver physiology and pathologyNeurogenesis and neuroplasticity mechanisms

Cited by 73

3D Cultivation Techniques for Primary Human Hepatocytes

Bachmann, A., Moll, M., Gottwald, E., Nies, C., Zantl, R., Wagner, H., Burkhardt, B., Sánchez, J., Ladurner, R., Thasler, W., et al. (2015) · Microarrays

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 59

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition

Deharde, D., Schneider, C., Hiller, T., Fischer, N., Kegel, V., Lübberstedt, M., Freyer, N., Hengstler, J. G., Andersson, T. B., Seehofer, D., et al. (2016) · Archives of Toxicology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 58

Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity

Ruoß, M., Damm, G., Vosough, M., Ehret, L., Grom-Baumgarten, C., Petkov, M., Naddalin, S., Ladurner, R., Seehofer, D., Nussler, A., et al. (2019) · International Journal of Molecular Sciences

Pharmacogenetics and Drug MetabolismEpigenetics and DNA Methylation

Cited by 37

Human parenchymal and non-parenchymal liver cell isolation, culture and characterization

Damm, G., Pfeiffer, E., Burkhardt, B., Vermehren, J., Nüssler, A. K., & Weiss, T. S. (2013) · Hepatology International

Liver physiology and pathologyOrgan Transplantation Techniques and Outcomes

Cited by 36

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

Sobotta, S., Raue, A., Huang, X., Vanlier, J., Jünger, A., Bohl, S., Albrecht, U., Hahnel, M. J., Wolf, S., Mueller, N. S., et al. (2017) · Frontiers in Physiology

Cytokine Signaling Pathways and InteractionsGene Regulatory Network Analysis

Cited by 28

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

Kolbe, E., Aleithe, S., Rennert, C., Spormann, L., Ott, F., Meierhofer, D., Gajowski, R., Stöpel, C., Hoehme, S., Kücken, M., et al. (2019) · Cell Reports

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 22

Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-matrigel matrices

Seidemann, L., Prinz, S., Scherbel, J.-C., Götz, C., Seehofer, D., & Damm, G. (2023) · IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 3

Investigation and Distinction of Energy Metabolism in Proliferating Hepatocytes and Hepatocellular Carcinoma Cells

Nerusch, J., Schicht, G., Herzog, N., Küpper, J.-H., Seehofer, D., & Damm, G. (2025) · Cells

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 3