Karayiorgou, Maria

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorPharmacogenetics and Drug Metabolism

Cited by 864

Strong association of de novo copy number mutations with sporadic schizophrenia

Xu, B., Roos, J. L., Levy, S., van Rensburg, E. J., Gogos, J. A., & Karayiorgou, M. (2008) · Nature Genetics

Genomic variations and chromosomal abnormalitiesSchizophrenia research and treatment

Cited by 813

Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

Sigurdsson, T., Stark, K. L., Karayiorgou, M., Gogos, J. A., & Gordon, J. A. (2010) · Nature

Schizophrenia research and treatmentNeural dynamics and brain function

Cited by 702

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

Stark, K. L., Xu, B., Bagchi, A., Lai, W.-S., Liu, H., Hsu, R., Wan, X., Pavlidis, P., Mills, A. A., Karayiorgou, M., et al. (2008) · Nature Genetics

Genomic variations and chromosomal abnormalitiesMicroRNA in disease regulation

Cited by 648

Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

Karayiorgou, M., Morris, M. A., Morrow, B., Shprintzen, R. J., Goldberg, R., Borrow, J., Gos, A., Nestadt, G., Wolyniec, P. S., & Lasseter, V. K. (1995) · Proceedings of the National Academy of Sciences

Genomic variations and chromosomal abnormalitiesSchizophrenia research and treatment

Cited by 628

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

Karayiorgou, M., Simon, T. J., & Gogos, J. A. (2010) · Nature Reviews Neuroscience

Genomic variations and chromosomal abnormalitiesSchizophrenia research and treatment

Cited by 474

De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia

Xu, B., Ionita-Laza, I., Roos, J. L., Boone, B., Woodrick, S., Sun, Y., Levy, S., Gogos, J. A., & Karayiorgou, M. (2012) · Nature Genetics

Schizophrenia research and treatmentGenomic variations and chromosomal abnormalities

Cited by 442

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H.-H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., et al. (2011) · Nature

Schizophrenia research and treatmentGenomic variations and chromosomal abnormalities

Cited by 337

High frequencies of de novo CNVs in bipolar disorder and schizophrenia

Malhotra, D., McCarthy, S., Michaelson, J. J., Vacic, V., Burdick, K. E., Yoon, S., Cichon, S., Corvin, A., Gary, S., Gershon, E. S., et al. (2011) · Neuron

Genomic variations and chromosomal abnormalitiesBipolar Disorder and Treatment

Cited by 325

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

Liu, H., Heath, S. C., Sobin, C., Roos, J. L., Galke, B. L., Blundell, M. L., Lenane, M., Robertson, B., Wijsman, E. M., Rapoport, J. L., et al. (2002) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentGenomic variations and chromosomal abnormalities

Cited by 323

Genotype determining low catechol- O -methyltransferase activity as a risk factor for obsessive-compulsive disorder

Karayiorgou, M., Altemus, M., Galke, B. L., Goldman, D., Murphy, D. L., Ott, J., & Gogos, J. A. (1997) · Proceedings of the National Academy of Sciences

Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on Behavior

Cited by 304

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

Kvajo, M., McKellar, H., Arguello, P. A., Drew, L. J., Moore, H., MacDermott, A. B., Karayiorgou, M., & Gogos, J. A. (2008) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 268

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

Mukai, J., Dhilla, A., Drew, L. J., Stark, K. L., Cao, L., MacDermott, A. B., Karayiorgou, M., & Gogos, J. A. (2008) · Nature Neuroscience

Genomic variations and chromosomal abnormalitiesGenetics and Neurodevelopmental Disorders

Cited by 260

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

Qi, Y., Zhang, X.-J., Renier, N., Wu, Z., Atkin, T., Sun, Z., Ozair, M. Z., Tchieu, J., Zimmer, B., Fattahi, F., et al. (2017) · Nature Biotechnology

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 248

Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene

Takata, A., Xu, B., Ionita-Laza, I., Roos, J. L., Gogos, J. A., & Karayiorgou, M. (2014) · Neuron

Schizophrenia research and treatmentGenetic Associations and Epidemiology

Cited by 204

Deficiency of Dgcr8 , a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex

Fénelon, K., Mukai, J., Xu, B., Hsu, P.-K., Drew, L. J., Karayiorgou, M., Fischbach, G. D., MacDermott, A. B., & Gogos, J. A. (2011) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Cited by 202

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

Gilman, S. R., Chang, J., Xu, B., Bawa, T. S., Gogos, J. A., Karayiorgou, M., & Vitkup, D. (2012) · Nature Neuroscience

Schizophrenia research and treatmentBioinformatics and Genomic Networks

Cited by 200

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

Karayannis, T., Au, E., Patel, J. C., Kruglikov, I., Markx, S., Delorme, R., Héron, D., Salomon, D., Glessner, J., Restituito, S., et al. (2014) · Nature

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 183

Molecular Substrates of Altered Axonal Growth and Brain Connectivity in a Mouse Model of Schizophrenia

Mukai, J., Tamura, M., Fénelon, K., Rosen, A. M., Spellman, T. J., Kang, R., MacDermott, A. B., Karayiorgou, M., Gordon, J. A., & Gogos, J. A. (2015) · Neuron

Schizophrenia research and treatmentAxon Guidance and Neuronal Signaling

Cited by 178

Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion

Xu, B., Hsu, P.-K., Stark, K. L., Karayiorgou, M., & Gogos, J. A. (2013) · Cell

MicroRNA in disease regulationGenomic variations and chromosomal abnormalities

Cited by 145

The Pattern of Cortical Dysfunction in a Mouse Model of a Schizophrenia-Related Microdeletion

Fénelon, K., Xu, B., Lai, C. S., Mukai, J., Markx, S., Stark, K. L., Hsu, P.-K., Gan, W.-B., Fischbach, G. D., MacDermott, A. B., et al. (2013) · The Journal of Neuroscience

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 116

Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice

Desbonnet, L., Tighe, O., Karayiorgou, M., Gogos, J. A., Waddington, J. L., & O’Tuathaigh, C. M. P. (2012) · Behavioural Brain Research

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 38

Advancing drug discovery for schizophrenia

Marder, S. R., Roth, B., Sullivan, P. F., Scolnick, E. M., Nestler, E. J., Geyer, M. A., Welnberger, D. R., Karayiorgou, M., Guidotti, A., Gingrich, J., et al. (2011) · Annals of the New York Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

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