Advancing drug discovery for schizophrenia
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Sponsored by the New York Academy of Sciences and with support from the National Institute of Mental Health, the Life Technologies Foundation, and the Josiah Macy Jr. Foundation, “Advancing Drug Discovery for Schizophrenia” was held March 9–11 at the New York Academy of Sciences in New York City. The meeting, comprising individual talks and panel discussions, highlighted basic, clinical, and translational research approaches, all of which contribute to the overarching goal of enhancing the pharmaceutical armamentarium for treating schizophrenia. This report surveys work by the vanguard of schizophrenia research in such topics as genetic and epigenetic approaches; small molecule therapeutics; and the relationships between target genes, neuronal function, and symptoms of schizophrenia.
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Current models of schizophrenia suggest that the disorder is due to both common and rare gene mutations, copy-number variations, and possibly epigenetic factors, all of which can affect multiple brain neurotransmitter systems and multiple risk genes.
“Current models of schizophrenia suggest that the disorder is due to both common and rare gene mutations, copy-number variations, and possibly epigenetic factors [361], all of which can affect multiple brain neurotransmitter systems and multiple risk genes [362-364].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [364]
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- Authors
- Marder, S. R., Roth, B., Sullivan, P. F., Scolnick, E. M., Nestler, E. J., Geyer, M. A., Welnberger, D. R., Karayiorgou, M., Guidotti, A., Gingrich, J., Akbarian, S., Buchanan, R. W., Lieberman, J. A., Conn, P. J., Haggarty, S. J., Law, A. J., Campbell, B., Krystal, J. H., Moghaddam, B., Saw, A., Caron, M. G., George, S. R., Allen, J. A., & Solis, M.
- Affiliations
- University of California, Los Angeles (US)
- University of North Carolina at Chapel Hill (US)
- Broad Institute (US)
- University of California San Diego (US)
- National Institutes of Health (US)
- New York State Psychiatric Institute (US)
- University of Illinois Chicago (US)
- University of Massachusetts Chan Medical School (US)
- University of Maryland, Baltimore (US)
- Vanderbilt University Medical Center (US)
- Pfizer (United States) (US)
- Yale University (US)
- University of Pittsburgh (US)
- Johns Hopkins University (US)
- Duke Medical Center (US)
- Centre for Addiction and Mental Health (CA)
- ORCID
- Marder, Stephen R.
- Roth, Bryan
- Sullivan, Patrick F.
- Scolnick, Edward M.
- Nestler, Eric J.
- Geyer, Mark A.
- Karayiorgou, Maria
- Guidotti, Alessandro
- Gingrich, Jay
- Akbarian, Schahram
- Buchanan, Robert W.
- Lieberman, Jeffrey A.
- Conn, P. Jeffrey
- Haggarty, Stephen J.
- Law, Amanda J.
- Krystal, John H.
- Moghaddam, Bita
- Caron, Marc G.
- Allen, John A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-10
- Volume
- 1236
- Issue
- 1
- Pages
- 30-43
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC3787879
- OpenAlex
- W1492606176
- Cited by
- 25
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 12
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute of Mental Health (R01MH095088)
- National Institute on Drug Abuse (R01DA007223)
- National Institute of Neurological Disorders and Stroke (R01NS031373)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, drug discovery, antipsychotic drugs, genetic approaches, epigenetics, small molecule drugs, target genes, neuronal function, schizophrenia symptoms, translational research
- MeSH terms
- Animals, Disease Models, Animal, Humans, Models, Biological, New York, Research, Research Design, Schizophrenia, Antipsychotic Agents, Genome-Wide Association Study, Drug Discovery, Epigenomics, Molecular Targeted Therapy
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