Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia
Open accessAbstract
Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large (>500-kilobase) CNVs at several loci, including microdeletions at 1q21.1 (ref. 2), 3q29 (ref. 3), 15q13.3 (ref. 2) and 22q11.2 (ref. 4) and microduplication at 16p11.2 (ref. 5). However, these CNVs collectively account for a small fraction (2-4%) of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 (0.35%) patients versus 2 of 7,431 (0.03%) controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs.
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In humans, duplication of the vasoactive intestinal polypeptide receptor (Vipr2) is associated with increased risk for schizophrenia.
“In humans, duplication of the vasoactive intestinal polypeptide receptor (Vipr2) is associated with increased risk for SZ170,171.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [170]
Disease-associated VIPR2 variants result in overexpression of VIPR2 and increased cyclic-AMP accumulation.
“Disease associated variants result in overexpression of VIPR2 and increased cyclic-AMP accumulation (Vacic et al., 2011).”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Vacic et al., 2011
Rare microduplications of VIPR2 are significantly associated with schizophrenia.
“Rare microduplications of VIPR2 are significantly associated with schizophrenia (Vacic et al., 2011).”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Vacic et al., 2011
The three significant schizophrenia regions correspond to CNVs previously implicated in schizophrenia at 3q29, 7q36.3, and 16p11.2.
“In schizophrenia, three genomic regions were significant (Table S6B), all corresponding to CNVs that have been previously implicated in schizophrenia at 3q29 (Mulle et al., 2010), 7q36.3 (Vacic et al., 2011), and 16p11.2 (McCarthy et al., 2009).”
From High frequencies of de novo CNVs in bipolar disorder and schizophrenia (2011) · cites this paper as Vacic et al., 2011
The enriched pathways were tested in rare CNVs from large independent case-control datasets: 8,290 schizophrenia cases and 7,431 controls from Vacic et al., a combined sample from three studies, and a bipolar disorder case-control set of 2,777 cases and 3,508 controls from BiGS.
“We extended our analysis of pathways identified in this study (Table 4 and Table 5, and S7) to rare CNVs from large case-controls studies of SCZ and BD. These included rare CNVs from 8,290 SCZ cases and 7,431 controls from Vacic et al. (2011), a combined sample of three studies from our group, MGS (Levinson et al., 2011), and the International Schizophrenia Consortium (International Schizophrenia”
From High frequencies of de novo CNVs in bipolar disorder and schizophrenia (2011) · cites this paper as Vacic et al. (2011)
Several individual CNV loci have been strongly implicated as risk factors for schizophrenia.
“several individual CNV loci have been strongly implicated as risk factors for schizophrenia with high degrees of statistical confidence. These include deletions at 1q21.1, NRXN1, 3q29, 15q11.2, 15q13.3, 22q11.2 and duplications at VIPR2, 16p11.2, 16p13.1 and 15q11-q13.2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13”
From De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia (2012) · cites this paper as [8]
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Cites
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745 · see citing works
Rare chromosomal deletions and duplications increase risk of schizophrenia
The International Schizophrenia Consortium (2008) · Nature · doi:10.1038/nature07239 · Cited by 1,475 · see citing works
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
The Autism Genome Project Consortium (2007) · Nature Genetics · doi:10.1038/ng1985 · Cited by 1,402 · see citing works
Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
Gottschling, D. E., Aparicio, O. M., Billington, B. L., & Zakian, V. A. (1990) · Cell · doi:10.1016/0092-8674(90)90141-z · Cited by 1,325 · see citing works
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154 · see citing works
Y chromosome sequence variation and the history of human populations
Underhill, P. A., Shen, P., Lin, A. A., Li, J., Passarino, G., Yang, W., Kauffman, E. E., Bonné, B., Bertranpetit, J., Francalacci, P., et al. (2000) · Nature Genetics · doi:10.1038/81685 · Cited by 990 · see citing works
Microduplications of 16p11.2 are associated with schizophrenia
Wellcome Trust Case Control Consortium, McCarthy, S. E., Makarov, V., Kirov, G., Addington, A. M., McClellan, J., Yoon, S., Perkins, D. O., Dickel, D. E., Kusenda, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.474 · Cited by 711 · see citing works
Self-citationDISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling
Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., et al. (2005) · Science · doi:10.1126/science.1112915 · Cited by 648 · see citing works
Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.
Karayiorgou, M., Morris, M. A., Morrow, B., Shprintzen, R. J., Goldberg, R., Borrow, J., Gos, A., Nestadt, G., Wolyniec, P. S., & Lasseter, V. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7612 · Cited by 628 · see citing works
Self-citationThe VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
Harmar, A. J., Marston, H. M., Shen, S., Spratt, C., West, K. M., Sheward, W. J., Morrison, C. F., Dorin, J. R., Piggins, H. D., Reubi, J.-C., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00736-5 · Cited by 549 · see citing works
Disruption of the neurexin 1 gene is associated with schizophrenia
Rujescu, D., Ingason, A., Cichon, S., Pietiläinen, O. P. H., Barnes, M. R., Toulopoulou, T., Picchioni, M., Vassos, E., Ettinger, U., Bramon, E., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn351 · Cited by 471 · see citing works
Sebat, J., Levy, D. L., & McCarthy, S. E. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.10.004 · Cited by 260 · see citing works
Self-citationMicrodeletions of 3q29 confer high risk for schizophrenia
Mulle, J. G., Dodd, A. F., McGrath, J. A., Wolyniec, P. S., Mitchell, A. A., Shetty, A. C., Sobreira, N. L., Valle, D., Rudd, M. K., Satten, G., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.013 · Cited by 223 · see citing works
Koering, C., Pollice, A., Zibella, M. P., Bauwens, S., Puisieux, A., Brunori, M., Brun, C., Martins, L., Sabatier, L., Pulitzer, J. F., et al. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf215 · Cited by 177 · see citing works
Transmitter Role of Vasoactive Intestinal Peptide
Fahrenkrug, J. (1993) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1993.tb01344.x · Cited by 151 · see citing works
Emergence of orphan drugs in the United States: a quantitative assessment of the first 25 years
Braun, M. M., Farag-El-Massah, S., Xu, K., & Coté, T. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3160 · Cited by 148 · see citing works
Singleton deletions throughout the genome increase risk of bipolar disorder
Zhang, D., Cheng, L., Qian, Y., Alliey-Rodriguez, N., Kelsoe, J. R., Greenwood, T., Nievergelt, C., Barrett, T. B., McKinney, R., Schork, N., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.144 · Cited by 148 · see citing works
Self-citationSheward, W. J., Lutz, E. M., & Harmar, A. J. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00048-n · Cited by 123 · see citing works
Brown, T. M., Colwell, C. S., Waschek, J. A., & Piggins, H. D. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01206.2006 · Cited by 109 · see citing works
Tyson, C., Harvard, C., Locker, R., Friedman, J. M., Langlois, S., Lewis, M. E. S., Allen, M. I. V., Somerville, M. J., Arbour, L. T., Clarke, L. A., et al. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31015 · Cited by 107 · see citing works
Moreno, D. A., Gourlet, P., NEEF, P. D., et al. (2000) · Peptides · doi:10.1016/s0196-9781(00)00309-0 · Cited by 79 · see citing works
Wu, Y., Ji, T., Wang, J., Xiao, J., Wang, H., Li, J., Gao, Z., Yang, Y., Cai, B., Wang, L., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-72 · Cited by 77 · see citing works
Vasoactive intestinal peptide: an important trophic factor and developmental regulator?
Waschek, J. A. (2010) · Developmental Neuroscience · doi:10.1159/000111268 · Cited by 73 · see citing works
Select cognitive deficits in vasoactive intestinal peptide deficient mice
Chaudhury, D., Loh, D. H., Dragich, J. M., Hagopian, A., & Colwell, C. S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-63 · Cited by 73 · see citing works
Turetsky, B. I., & Moberg, P. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07071210 · Cited by 71 · see citing works
Yang, K., Trepanier, C. H., Li, H., Beazely, M. A., Lerner, E. A., Jackson, M. F., & MacDonald, J. F. (2009) · Hippocampus · doi:10.1002/hipo.20559 · Cited by 44 · see citing works
Zaben, M., Sheward, W. J., Shtaya, A., Abbosh, C., Harmar, A. J., Pringle, A. K., & Gray, W. (2009) · Stem Cells · doi:10.1002/stem.184 · Cited by 42 · see citing works
Identification and Characterization of a Small Molecule Antagonist of Human VPAC2 Receptor
Chu, A., Caldwell, J. S., & Chen, Y. A. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.060137 · Cited by 34 · see citing works
Morava, É., Bartsch, O., Czakó, M., et al. (2003) · PubMed · doi:10.1097/01.mcd.0000059768.40218.9b · Cited by 25 · see citing works
Morava, �., Bartsch, O., Czak�, M., et al. (2003) · Clinical Dysmorphology · doi:10.1097/00019605-200304000-00010 · Cited by 23 · see citing works
Bartsch, O., Vlčková, Z., Erdogan, F., et al. (2007) · Cytogenetic and Genome Research · doi:10.1159/000109634 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Marshall, C. R., Howrigan, D. P., Merico, D., Thiruvahindrapuram, B., Wu, W., Greer, D. S., Antaki, D., Shetty, A., Holmans, P. A., Pinto, D., et al. (2017) · Nature Genetics · doi:10.1038/ng.3725 · Cited by 1,058 · see citing works
Self-citationShared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Gandal, M. J., Haney, J. R., Parikshak, N. N., Leppa, V., Ramaswami, G., Hartl, C., Schork, A. J., Appadurai, V., Buil, A., Werge, T. M., et al. (2018) · Science · doi:10.1126/science.aad6469 · Cited by 1,095 · see citing works
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854 · see citing works
Self-citationKirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.154 · Cited by 844 · see citing works
Gulsuner, S., Walsh, T., Watts, A. C., Lee, M. K., Thornton, A. M., Casadei, S., Rippey, C., Shahin, H., Braff, D., Cadenhead, K. S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.049 · Cited by 536 · see citing works
Self-citationArnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538 · see citing works
Genetics and genomics of psychiatric disease
Geschwind, D. H., & Flint, J. (2015) · Science · doi:10.1126/science.aaa8954 · Cited by 424 · see citing works
Analysis of copy number variations at 15 schizophrenia-associated loci
Rees, E., Walters, J. T. R., Georgieva, L., Isles, A. R., Chambert, K. D., Richards, A. L., Mahoney-Davies, G., Legge, S. E., Moran, J. L., McCarroll, S. A., et al. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.131052 · Cited by 443 · see citing works
Self-citationLarge-scale genomics unveils the genetic architecture of psychiatric disorders
Gratten, J., Wray, N. R., Keller, M. C., & Visscher, P. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3708 · Cited by 363 · see citing works
Calcium signalling remodelling and disease
Berridge, M. J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110766 · Cited by 391 · see citing works
High frequencies of de novo CNVs in bipolar disorder and schizophrenia
Malhotra, D., McCarthy, S., Michaelson, J. J., Vacic, V., Burdick, K. E., Yoon, S., Cichon, S., Corvin, A., Gary, S., Gershon, E. S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.11.007 · Cited by 325 · see citing works
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Visel, A., Taher, L., Girgis, H., May, D., Golonzhka, O., Hoch, R. V., McKinsey, G. L., Pattabiraman, K., Silberberg, S. N., Blow, M. J., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.041 · Cited by 257 · see citing works
Sleep and Circadian Rhythm Disruption in Social Jetlag and Mental Illness
Foster, R. G., Peirson, S. N., Wulff, K., Winnebeck, E., Vetter, C., & Roenneberg, T. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00011-7 · Cited by 224 · see citing works
Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia
Berridge, M. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1806-z · Cited by 181 · see citing works
Genomic Perspectives of Transcriptional Regulation in Forebrain Development
Nord, A. S., Pattabiraman, K., Visel, A., & Rubenstein, J. L. R. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.011 · Cited by 152 · see citing works
Links between circadian rhythms and psychiatric disease
Karatsoreos, I. N. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00162 · Cited by 146 · see citing works
Akula, N., Barb, J., Jiang, X., Wendland, J. R., Choi, K. H., Sen, S. K., Hou, L., Chen, D. T. W., Laje, G., Johnson, K., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.170 · Cited by 116 · see citing works
Genetic contributions to behavioural diversity at the gene-environment interface
Bendesky, A., & Bargmann, C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3065 · Cited by 103 · see citing works
Common variant at 16p11.2 conferring risk of psychosis
Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.157 · Cited by 104 · see citing works
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Hooli, B. V., Kovacs-Vajna, Z. M., Mullin, K., Blumenthal, M. A., Mattheisen, M., Zhang, C., Lange, C., Mohapatra, G., Bertram, L., & Tanzi, R. E. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.77 · Cited by 100 · see citing works
Mooney, M. A., Ryabinin, P., Wilmot, B., Bhatt, P., Mill, J., & Nigg, J. T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0710-4 · Cited by 91 · see citing works
Dougalis, A. G., Matthews, G. A. C., Bishop, M. W., Brischoux, F., Kobayashi, K., & Ungless, M. A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08255.x · Cited by 81 · see citing works
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Gratten, J., Visscher, P. M., Mowry, B. J., & Wray, N. R. (2013) · Nature Genetics · doi:10.1038/ng.2555 · Cited by 77 · see citing works
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Li, Z., Chen, J., Xu, Y., Yi, Q., Ji, W., Wang, P., Shen, J., Song, Z., Wang, M., Yang, P., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.012 · Cited by 72 · see citing works
Kogan, J. H., Gross, A. K., Featherstone, R. E., Shin, R., Chen, Q., Heusner, C. L., Adachi, M., Lin, A., Walton, N. M., Miyoshi, S., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3967-14.2015 · Cited by 59 · see citing works
Morris, D. W., Pearson, R. D., Cormican, P., Kenny, E. M., O'Dushlaine, C. T., Perreault, L.-P. L., Giannoulatou, E., Tropea, D., Maher, B. S., Wormley, B., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu025 · Cited by 42 · see citing works
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Chang, H., Li, L., Li, M., & Xiao, X. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2016.11.031 · Cited by 37 · see citing works
- Authors
- Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H.-H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., Iakoucheva, L. M., Krastoshevsky, O., Krause, V., Larach-Walters, V., Welsh, D. K., Craig, D., Kelsoe, J. R., Gershon, E. S., Leal, S. M., Aquila, M. D., Morris, D. W., Gill, M., Corvin, A., Insel, P. A., McClellan, J., King, M.-C., Karayiorgou, M., Levy, D. L., DeLisi, L. E., & Sebat, J.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- University of California San Diego (US)
- Icahn School of Medicine at Mount Sinai (US)
- McLean Hospital (US)
- Translational Genomics Research Institute (US)
- University of Chicago (US)
- Baylor College of Medicine (US)
- Trinity College Dublin (IE)
- University of Washington (US)
- Columbia University (US)
- Harvard University (US)
- Corresponding author
- Sebat, Jonathan
- ORCID
- Vacic, Vladimir
- Malhotra, Dheeraj
- Murray, Fiona
- Makarov, Vladimir
- Bhandari, Abhishek
- Corominas, Roser
- Iakoucheva, Lilia M.
- Welsh, David K.
- Craig, David
- Kelsoe, John R.
- Gershon, Elliot S.
- Leal, Suzanne M.
- Morris, Derek W.
- Gill, Michael
- Corvin, Aiden
- Insel, Paul A.
- McClellan, Jon
- King, Mary-Claire
- Karayiorgou, Maria
- Levy, Deborah L.
- Sebat, Jonathan
- Venue
- Nature
- Published
- 2011-02-23
- Volume
- 471
- Issue
- 7339
- Pages
- 499-503
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3351382
- OpenAlex
- W2156825608
- Cited by
- 337
- References
- 31
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 12 · 2020: 9 · 2019: 22 · 2018: 16 · 2017: 12 · 2016: 22 · 2015: 23 · 2014: 36 · 2013: 50 · 2012: 51
- FWCI
- 36.96
- Type
- journal article
- Language
- en
- Update notices
- erratum (2011-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Repositorio Institucional Académico , Sistema de Bibliotecas Universidad Andrés Bello (UNAB) (Universidad Andrés Bello (UNAB)) (submittedVersion, cc-by)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Wellcome Trust (072894/Z/03/Z)
- National Institutes of Health (2r01mh044245-06a1, 5r01mh071523-05)
- National Heart, Lung, and Blood Institute (R00HL091061, K99HL091061)
- National Institute of Mental Health (MH061399, R01MH091350, R01MH061399, MH044245, MH076431, MH071523, R01MH082945, MH082945, R01-MH071523, MH083989, R01MH083989, R01MH076431)
- National Human Genome Research Institute (P41HG004222, HG04222)
- National Institute of General Medical Sciences (GM–66232, R01GM066232)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- schizophrenia, copy number variation, gene duplication, VIPR2, vasoactive intestinal peptide receptor, microduplication, cAMP signaling, antipsychotic drug targets, genetic risk, lymphocytes, genome-wide association study, rare copy number variants
- MeSH terms
- Cyclic AMP, Cell Line, Chromosomes, Human, Pair 7, Female, Humans, Male, Pedigree, Schizophrenia, Transcription, Genetic, Reproducibility of Results, Cohort Studies, Signal Transduction, Gene Dosage, Genetic Predisposition to Disease, Genes, Duplicate, Inheritance Patterns, Receptors, Vasoactive Intestinal Peptide, Type II, Genome-Wide Association Study, DNA Copy Number Variations
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