Mitchell, Michael J.

Engineering precision nanoparticles for drug delivery

Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery

Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Cited by 7,933

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

Oberli, M. A., Reichmuth, A. M., Dorkin, J. R., Mitchell, M. J., Fenton, O. S., Jaklenec, A., Anderson, D. G., Langer, R., & Blankschtein, D. (2017) · Nano Letters

RNA Interference and Gene DeliveryImmunotherapy and Immune Responses

Cited by 719

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters

RNA Interference and Gene DeliveryCAR-T cell therapy research

Cited by 636

An ionizable lipid toolbox for RNA delivery

Han, X., Zhang, H., Butowska, K., Swingle, K. L., Alameh, M.-G., Weissman, D., & Mitchell, M. J. (2021) · Nature Communications

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 628

Nanoparticle protein corona: from structure and function to therapeutic targeting

Bashiri, G., Padilla, M. S., Swingle, K. L., Shepherd, S. J., Mitchell, M. J., & Wang, K. (2023) · Lab on a Chip

Nanoparticle-Based Drug DeliveryProtein Interaction Studies and Fluorescence Analysis

Cited by 296

Engineering and physical sciences in oncology: challenges and opportunities

Mitchell, M. J., Jain, R. K., & Langer, R. (2017) · Nature Reviews Cancer

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 273

Ionizable lipid nanoparticles for in utero mRNA delivery

Riley, R. S., Kashyap, M. V., Billingsley, M. M., White, B., Alameh, M.-G., Bose, S. K., Zoltick, P. W., Li, H., Zhang, R., Cheng, A. Y., et al. (2021) · Science Advances

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 222

Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress

Mitchell, M. J., & King, M. R. (2013) · Frontiers in Oncology

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 221

Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain

Han, E. L., Tang, S., Kim, D., Murray, A. M., Swingle, K. L., Hamilton, A. G., Mrksich, K., Padilla, M. S., Palanki, R., Li, J. J., et al. (2025) · Nano Letters

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 158

Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy

Swingle, K. L., Safford, H. C., Geisler, H. C., Hamilton, A. G., Thatte, A. S., Billingsley, M. M., Joseph, R. A., Mrksich, K., Padilla, M. S., Ghalsasi, A. A., et al. (2023) · Journal of the American Chemical Society

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 145

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

Swingle, K. L., Hamilton, A. G., Safford, H. C., Geisler, H. C., Thatte, A. S., Palanki, R., Murray, A. M., Han, E. L., Mukalel, A. J., Han, X., et al. (2025) · Nature

RNA Interference and Gene DeliveryPregnancy and preeclampsia studies

Cited by 129

Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease

Palanki, R., Bose, S. K., Dave, A., White, B. M., Berkowitz, C., Luks, V., Yaqoob, F., Han, E., Swingle, K. L., Menon, P., et al. (2023) · ACS Nano

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 77

Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing

Han, E. L., Padilla, M. S., Palanki, R., Kim, D., Mrksich, K., Li, J. J., Tang, S., Yoon, I.-C., & Mitchell, M. J. (2024) · Nano Letters

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 72

Delivery technologies for in utero gene therapy

Palanki, R., Peranteau, W. H., & Mitchell, M. J. (2021) · Advanced Drug Delivery Reviews

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 64

Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery

Swingle, K. L., Billingsley, M. M., Bose, S. K., White, B., Palanki, R., Dave, A., Patel, S. K., Gong, N., Hamilton, A. G., Alameh, M.-G., et al. (2022) · Journal of Controlled Release

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 64

High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain

Han, E. L., Kim, D., Murray, A. M., Mrksich, K., Hamilton, A. G., Tang, S., Yoo, S., Zhu, A. T., Tong, E. R., Palanki, R., et al. (2026) · ACS Nano

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 5