SELECTION FOR FITNESS VERSUS SELECTION FOR ROBUSTNESS IN RNA SECONDARY STRUCTURE FOLDING
Abstract
I investigate the competition between two quasispecies residing on two disparate neutral networks. Under the assumption that the two neutral networks have different topologies and fitness levels, it is the mutation rate that determines which quasispecies will eventually be driven to extinction. For small mutation rates, I find that the quasispecies residing on the neutral network with the lower replication rate will disappear. For higher mutation rates, however, the faster replicating sequences may be outcompeted by the slower replicating ones if the connection density on the second neutral network is sufficiently high. The analytical results are in excellent agreement with flow-reactor simulations of replicating RNA sequences.
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Too much lethal mutation pushes the population to the extinction threshold and stops self-replication of the protocell.
“too much lethal mutation push the population to the extinction threshold [15] and the self-replication of proto-cell will stop.”
From Lethal mutants and truncated selection together solve a paradox of the origin of life (2011) · cites this paper as [15]
The suggested mechanism solves the error threshold for the second stage, but not for the third stage.
“The mechanism we suggested solves the error threshold for the second stage, but not for the third stage: too much lethal mutation push the population to the extinction threshold [15] and the self-replication of proto-cell will stop.”
From Lethal mutants and truncated selection together solve a paradox of the origin of life (2011) · cites this paper as [15]
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Self-citationIntroduction: Issues About Robustness in the Practice of Biological Sciences
Bertolaso, M., Serrelli, E., & Caianiello, S. (2018) · History, philosophy and theory of the life sciences · doi:10.1007/978-3-030-01198-7_1
- Authors
- Wilke, C. O.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Wilke, Claus O.
- ORCID
- Wilke, Claus O.
- Venue
- Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12
- Volume
- 55
- Issue
- 12
- Pages
- 2412-2420
- ISSN
- 0014-3820 (ISSN-L)
- 1558-5646
- OpenAlex
- W2241496350
- Cited by
- 76
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Evolution (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Keywords
- quasispecies, neutral networks, mutation rate, replication rate, extinction, connection density
- MeSH terms
- Base Sequence, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Probability, RNA, Selection, Genetic, Neural Networks, Computer
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