Ebert, Benjamin L.

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Bernard, E., Nannya, Y., Hasserjian, R. P., Devlin, S. M., Tuechler, H., Medina-Martinez, J. S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., et al. (2020) · Nature Medicine

Acute Myeloid Leukemia ResearchCancer-related Molecular Pathways

Cited by 648

Hypoxic Regulation of Lactate Dehydrogenase A

Firth, J. D., Ebert, B. L., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 576

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

Heckl, D., Kowalczyk, M. S., Yudovich, D., Belizaire, R., Puram, R. V., McConkey, M. E., Thielke, A., Aster, J. C., Regev, A., & Ebert, B. L. (2014) · Nature Biotechnology

CRISPR and Genetic EngineeringAcute Myeloid Leukemia Research

Cited by 555

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Sievers, Q. L., Petzold, G., Bunker, R. D., Renneville, A., Słabicki, M., Liddicoat, B. J., Abdulrahman, W., Mikkelsen, T., Ebert, B. L., & Thomä, N. H. (2018) · Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 537

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Donovan, K. A., An, J., Nowak, R. P., Yuan, J. C., Fink, E. C., Berry, B. C., Ebert, B. L., & Fischer, E. S. (2018) · eLife

Congenital limb and hand anomaliesDevelopmental Biology and Gene Regulation

Cited by 509

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Wolach, O., Sellar, R. S., Martinod, K., Cherpokova, D., McConkey, M., Chappell, R. J., Silver, A. J., Adams, D., Castellano, C. A., Schneider, R. K., et al. (2018) · Science Translational Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 481

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

Gibson, C. J., Lindsley, R. C., Tchekmedyian, V., Mar, B. G., Shi, J., Jaiswal, S., Bosworth, A., Francisco, L., He, J., Bansal, A., et al. (2017) · Journal of Clinical Oncology

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 480

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Kurppa, K. J., Liu, Y., To, C., Zhang, T., Fan, M., Vajdi, A., Knelson, E. H., Xie, Y., Lim, K., Cejas, P., et al. (2020) · Cancer Cell

Hippo pathway signaling and YAP/TAZLung Cancer Treatments and Mutations

Cited by 475

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M., Krivtsov, A. V., Giacomelli, A. O., Wong, W., Kim, J., Chao, S., et al. (2019) · Science

Cancer-related Molecular PathwaysAcute Myeloid Leukemia Research

Cited by 441

Targeted protein degradation: from mechanisms to clinic

Tsai, J. M., Nowak, R. P., Ebert, B. L., & Fischer, E. S. (2024) · Nature Reviews Molecular Cell Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 438

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Słabicki, M., Kozicka, Z., Petzold, G., Li, Y.-D., Manojkumar, M., Bunker, R. D., Donovan, K. A., Sievers, Q. L., Koeppel, J., Suchyta, D., et al. (2020) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 433

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

Obeng, E. A., Chappell, R. J., Seiler, M., Chen, M. C., Campagna, D. R., Schmidt, P. J., Schneider, R. K., Lord, A. M., Wang, L., Gambe, R. G., et al. (2016) · Cancer Cell

RNA Research and SplicingAcute Myeloid Leukemia Research

Cited by 380

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W., et al. (2011) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 326

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 295

Core circadian clock genes regulate leukemia stem cells in AML

Puram, R. V., Kowalczyk, M. S., de Boer, C. G., Schneider, R. K., Miller, P. G., McConkey, M., Tothova, Z., Tejero, H., Heckl, D., Järås, M., et al. (2016) · Cell

Circadian rhythm and melatoninAcute Myeloid Leukemia Research

Cited by 274

Small-molecule-induced polymerization triggers degradation of BCL6

Słabicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., et al. (2020) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 270

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

for the International Working Group for MDS Molecular Prognostic Committee, Haase, D., Stevenson, K. E., Neuberg, D., Maciejewski, J. P., Nazha, A., Sekeres, M. A., Ebert, B. L., Garcia-Manero, G., Haferlach, C., et al. (2019) · Leukemia

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 259

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

Miller, P. G., Qiao, D., Rojas-Quintero, J., Honigberg, M. C., Sperling, A. S., Gibson, C. J., Bick, A. G., Niroula, A., McConkey, M. E., Sandoval, B., et al. (2022) · Blood

Chronic Obstructive Pulmonary Disease (COPD) ResearchAcute Myeloid Leukemia Research

Cited by 235

Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo

Kim, W. Y., Safran, M., Buckley, M. R., Ebert, B. L., Glickman, J., Bosenberg, M., Regan, M., & Kaelin, W. G. (2006) · The EMBO Journal

Cancer, Hypoxia, and MetabolismEar and Head Tumors

Cited by 235

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

Ramos, P., Casu, C., Gardenghi, S., Breda, L., Crielaard, B. J., Guy, E., Marongiu, M. F., Gupta, R., Levine, R. L., Abdel-Wahab, O., et al. (2013) · Nature Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentErythropoietin and Anemia Treatment

Cited by 227

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Kahn, J. D., Miller, P. G., Silver, A. J., Sellar, R. S., Bhatt, S., Gibson, C., McConkey, M., Adams, D., Mar, B., Mertins, P., et al. (2018) · Blood

Protein Tyrosine PhosphatasesAcute Myeloid Leukemia Research

Cited by 225

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Lee, S. C.-W., North, K., Kim, E., Jang, E., Obeng, E., Lu, S. X., Liu, B., Inoue, D., Yoshimi, A., Ki, M., et al. (2018) · Cancer Cell

RNA Research and SplicingAcute Myeloid Leukemia Research

Cited by 219

The novel mechanism of lenalidomide activity

Fink, E. C., & Ebert, B. L. (2015) · Blood

Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments

Cited by 213

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, J. E., Mak, R., Tanguturi, S. K., Mazitschek, R., Haggarty, S. J., Ross, K., Chang, C. Y., Bosco, J., West, N., Morse, E., et al. (2010) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHistone Deacetylase Inhibitors Research

Cited by 211