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Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms
Open accessAbstract
Thrombosis in myeloproliferative neoplasms is associated with increased NETosis that can be targeted with JAK inhibitors.
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JAK2 mutations prime neutrophils to form neutrophil extracellular traps, leading to thrombosis, which may also contribute to poor cardiovascular outcomes.
“Furthermore, JAK2 mutations prime neutrophils to form neutrophil extracellular traps, leading to thrombosis, which may also contribute to poor cardiovascular outcomes 82.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [82]
Individuals with CHIP-associated JAK2 mutations were reported to have an approximately 12 times greater risk of developing venous thrombosis than those without CHIP, whereas individuals with mutations in other CHIP-associated genes had a doubling of the risk.
“In a separate study (83), individuals with CHIP-associated JAK2 mutations were reported to have a ~12 times greater risk of developing venous thrombosis than those without CHIP, whereas individuals with mutations in other CHIP-associated genes had a doubling of the risk 82.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [82]
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Metadata
- Authors
- Wolach, O., Sellar, R. S., Martinod, K., Cherpokova, D., McConkey, M., Chappell, R. J., Silver, A. J., Adams, D., Castellano, C. A., Schneider, R. K., Padera, R. F., DeAngelo, D. J., Wadleigh, M., Steensma, D. P., Galinsky, I., Stone, R. M., Genovese, G., McCarroll, S. A., Iliadou, B., Hultman, C., Neuberg, D., Mullally, A., Wagner, D. D., & Ebert, B. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Boston Children's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Karolinska Institutet (SE)
- Corresponding author
- Wolach, Ofir
- Sellar, Rob S.
- Ebert, Benjamin L.
- ORCID
- Wolach, Ofir
- Sellar, Rob S.
- Martinod, Kimberly
- McConkey, Marie
- Silver, Alexander J.
- Castellano, Cecilia A.
- Schneider, Rebekka K.
- Padera, Robert F.
- DeAngelo, Daniel J.
- Wadleigh, Martha
- Steensma, David P.
- Galinsky, Ilene
- Stone, Richard M.
- Genovese, Giulio
- McCarroll, Steven A.
- Hultman, Christina
- Neuberg, Donna
- Mullally, Ann
- Wagner, Denisa D.
- Ebert, Benjamin L.
- Venue
- Science Translational Medicine
- Published
- 2018-04-11
- Volume
- 10
- Issue
- 436
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6442466
- OpenAlex
- W2796704538
- Cited by
- 481
- References
- 41
- Citations by year
- 2026: 50 · 2025: 58 · 2024: 66 · 2023: 58 · 2022: 73 · 2021: 69 · 2020: 48 · 2019: 44 · 2018: 13
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institutes of Health (R01HL082945)
- Howard Hughes Medical Institute
- Leukemia and Lymphoma Society
- Topics
- Health Sciences › Medicine › Hematology › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- neutrophil extracellular traps, thrombosis, myeloproliferative neoplasms, JAK2 inhibition, neutrophil function, NETosis
- MeSH terms
- Protein-Arginine Deiminase Type 4, Animals, Female, Hydrolases, Myeloproliferative Disorders, Nitriles, Pyrazoles, Pyrimidines, Thrombosis, Signal Transduction, Case-Control Studies, Hematologic Neoplasms, Cell Proliferation, STAT Transcription Factors, Mice, Janus Kinases, Janus Kinase 2, Extracellular Traps
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