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Coordinated regulation of protein synthesis and degradation by mTORC1
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Activation of mTORC1, which inhibits lysosomal degradation, increases the number of intact and active proteasomes through activation of NRF1.
“Specifically, activation of mTORC1, which inhibits lysosomal degradation, has been shown to increase the number of intact and active proteasomes through the activation of NRF1 (Zhang et al., 2014; Zhang and Manning, 2015).”
From Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning (2021) · cites this paper as Zhang et al., 2014
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Research works printed but not linked: 27
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“Specifically, activation of mTORC1, which inhibits lysosomal degradation, has been shown to increase the number of intact and active proteasomes through the activation of NRF1 (Zhang et al., 2014; Zhang & Manning, 2015).”
Background
Metadata
- Authors
- Zhang, Y., Nicholatos, J., Dreier, J. R., Ricoult, S. J. H., Widenmaier, S. B., Hotamisligil, G. S., Kwiatkowski, D. J., & Manning, B. D.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Manning, Brendan D.
- Venue
- Nature
- Published
- 2014-07-13
- Volume
- 513
- Issue
- 7518
- Pages
- 440-443
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4402229
- OpenAlex
- W2009966467
- Cited by
- 350
- References
- 0
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 18 · 2023: 27 · 2022: 21 · 2021: 35 · 2020: 31 · 2019: 38 · 2018: 29 · 2017: 45 · 2016: 33 · 2015: 26 · 2014: 9
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- National Cancer Institute (R01CA122617, P01CA120964)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- mTORC1, protein synthesis, protein degradation, proteasome, NRF1, amino acid availability, nutrient sensing, tuberous sclerosis complex, TSC1, TSC2, protein turnover, cellular homeostasis
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Amino Acids, Animals, Humans, Male, Mice, Inbred C57BL, Proteins, Transcription, Genetic, Protein Biosynthesis, Signal Transduction, Multiprotein Complexes, Proteasome Endopeptidase Complex, Nuclear Respiratory Factor 1, Mice, Sterol Regulatory Element Binding Protein 1, TOR Serine-Threonine Kinases, Proteolysis
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