Kern, Dorothee

Dynamic personalities of proteins

Henzler-Wildman, K., & Kern, D. (2007) · Nature

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 2,545

Predicting multiple conformations via sequence clustering and AlphaFold2

Wayment-Steele, H. K., Ojoawo, A., Otten, R., Apitz, J. M., Pitsawong, W., Hömberger, M., Ovchinnikov, S., Colwell, L., & Kern, D. (2024) · Nature

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 545

Protein language models learn evolutionary statistics of interacting sequence motifs

Zhang, Z., Wayment-Steele, H. K., Brixi, G., Wang, H., Kern, D., & Ovchinnikov, S. (2024) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 140

Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2

Pádua, R. A. P., Sun, Y., Marko, I., Pitsawong, W., Stiller, J. B., Otten, R., & Kern, D. (2018) · Nature Communications

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 133

Choreographing an enzyme's dance

Villali, J., & Kern, D. (2010) · Current Opinion in Chemical Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 98

From primordial clocks to circadian oscillators

Pitsawong, W., Pádua, R. A. P., Grant, T., Hoemberger, M., Otten, R., Bradshaw, N., Grigorieff, N., & Kern, D. (2023) · Nature

Circadian rhythm and melatoninLight effects on plants

Cited by 37

The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale

Wayment-Steele, H. K., Otten, R., Pitsawong, W., Ojoawo, A. M., Glaser, A., Calderone, L. A., & Kern, D. (2024) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsCircadian rhythm and melatonin

Cited by 19

The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale

Wayment-Steele, H. K., Otten, R., Pitsawong, W., Ojoawo, A. M., Glaser, A., Calderone, L. A., & Kern, D. (2024) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsCircadian rhythm and melatonin

Cited by 19

Does sequence clustering confound AlphaFold2?

Wayment-Steele, H. K., Ovchinnikov, S., Colwell, L., & Kern, D. (2024) · Journal of Molecular Biology

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 8