Huang, Wendong

Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration

Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 645

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

Wang, Y.-D., Chen, W.-D., Wang, M., Yu, D., Forman, B. M., & Huang, W. (2008) · Hepatology

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 639

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., & Huang, W. (2007) · Cancer Research

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 488

Bile acid nuclear receptor FXR and digestive system diseases

Ding, L., Yang, L., Wang, Z., & Huang, W. (2015) · Acta Pharmaceutica Sinica B

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 477

FXR: a metabolic regulator and cell protector

Wang, Y.-D., Chen, W.-D., Moore, D. D., & Huang, W. (2008) · Cell Research

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 389

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J. M., Lozano, G., & Moore, D. D. (2005) · Molecular Endocrinology

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 284

The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity

Zhang, J., Huang, W., Qatanani, M., Evans, R. M., & Moore, D. D. (2004) · Journal of Biological Chemistry

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 246

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice

Zhang, L., Wang, Y.-D., Chen, W.-D., Wang, X., Lou, G., Liu, N., Lin, M., Forman, B. M., & Huang, W. (2012) · Hepatology

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 151

C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†

Blanco‐Bose, W. E., Murphy, M. J., Ehninger, A., Offner, S., Dubey, C., Huang, W., Moore, D. D., & Trumpp, A. (2008) · Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 138

Alterations in xenobiotic metabolism in the long‐lived Little mice

Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 134

Farnesoid X Receptor Alleviates Age-Related Proliferation Defects in Regenerating Mouse Livers by Activating Forkhead Box M1b Transcription

Chen, W.-D., Wang, Y.-D., Zhang, L., Shiah, S., Wang, M., Yang, F., Yu, D., Forman, B. M., & Huang, W. (2010) · Hepatology

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 115

Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR

Huang, W., Zhang, J., Wei, P., Schrader, W. T., & Moore, D. D. (2004) · Molecular Endocrinology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 110

Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation

Li, S., Pan, H., Tan, C., Sun, Y., Song, Y., Zhang, X., Yang, W., Wang, X., Li, D., Dai, Y., et al. (2018) · Stem Cell Reports

Mitochondrial Function and PathologyCardiac electrophysiology and arrhythmias

Cited by 106

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis

Dong, B., Lee, J.-S., Park, Y.-Y., Yang, F., Xu, G., Huang, W., Finegold, M. J., & Moore, D. D. (2015) · Nature Communications

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 97

Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II

Meng, Z., Li, T., Ma, X., Wang, X., Van Ness, C., Gan, Y., Zhou, H., Tang, J., Lou, G., Wang, Y., et al. (2013) · Molecular Cancer Therapeutics

Hepatocellular Carcinoma Treatment and PrognosisBerberine and alkaloids research

Cited by 97

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-κB signaling pathway

Guo, C., Qi, H., Yu, Y., Zhang, Q., Su, J., Yu, D., Huang, W., Chen, W.-D., & Wang, Y.-D. (2015) · Frontiers in Pharmacology

Drug Transport and Resistance MechanismsNF-κB Signaling Pathways

Cited by 95

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

Zhang, E., Jin, L., Wang, Y., Tu, J., Zheng, R., Ding, L., Fang, Z., Fan, M., Al-Abdullah, I., Natarajan, R., et al. (2022) · Nature Communications

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 76

The environmental estrogen, nonylphenol, activates the constitutive androstane receptor

Hernandez, J. P., Huang, W., Chapman, L. M., Chua, S., Moore, D. D., & Baldwin, W. S. (2007) · Toxicological Sciences

Effects and risks of endocrine disrupting chemicalsPharmacogenetics and Drug Metabolism

Cited by 52

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

Xia, B., Gerstin, E., Schones, D. E., Huang, W., & Steven de Belle, J. (2016) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 41

Nuclear receptors and liver disease: summary of the 2017 basic research symposium

Tran, M., Liu, Y., Huang, W., & Wang, L. (2018) · Hepatology Communications

Liver physiology and pathologyNuclear Receptors and Signaling

Cited by 20