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Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

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Balancing Act: Exploring the Gut Microbiota-Brown Adipose Tissue Axis in PCOS Pathogenesis and Therapeutic Frontiers

Li, Y., Fang, Y., Wang, H., & Zhang, H. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906208 · Cited by 21 · see citing works

Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5-HT pathway

Li, S., Li, X., Wang, K., Li, Y., Nagaoka, K., & Li, C. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00950-0 · Cited by 19 · see citing works

Metabolic regulation by the intestinal metformin-AMPK axis

Zhang, S., & Lam, T. K. T. (2022) · Nature Communications · doi:10.1038/s41467-022-30477-3 · Cited by 18 · see citing works

Brown Fat and Nutrition: Implications for Nutritional Interventions

Noriega, L., Yang, C., & Wang, C. (2023) · Nutrients · doi:10.3390/nu15184072 · Cited by 19 · see citing works

Metformin: Diverse molecular mechanisms, gastrointestinal effects and overcoming intolerance in type 2 Diabetes Mellitus: A review

Mohamed, S. (2024) · Medicine · doi:10.1097/md.0000000000040221 · Cited by 16 · see citing works

Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways

Xu, Y., Li, N., Si, Y., Li, X., Wang, R., & Ren, Q. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1526109 · Cited by 14 · see citing works

Interactions between Intestinal Homeostasis and NAD+ Biology in Regulating Incretin Production and Postprandial Glucose Metabolism

Nagahisa, T., Kosugi, S., & Yamaguchi, S. (2023) · Nutrients · doi:10.3390/nu15061494 · Cited by 14 · see citing works

Dysbiosis versus diabesity: Pathological signaling and promising therapeutic strategies

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Striking a gut–liver balance for the antidiabetic effects of metformin

Barroso, E., Montori-Grau, M., Wahli, W., Palomer, X., & Vázquez‐Carrera, M. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.04.004 · Cited by 14 · see citing works

SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice

Yang, Y., Reid, M. A., Hanse, E. A., Li, H., Li, Y., Ruiz, B. I., Fan, Q., & Kong, M. (2023) · Nature Communications · doi:10.1038/s41467-023-36809-1 · Cited by 13 · see citing works

Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice

Guerbette, T., Ciesielski, V., Brien, M., Catheline, D., Viel, R., Bostoën, M., Perrin, J., Burel, A., Janvier, R., Rioux, V., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102098 · Cited by 13 · see citing works

Gut microbiota-bile acids-glucagon like peptide-1 axis contributes the resistance to high fat diet-induced obesity in mice

Chen, C., Liu, L., Zhong, Y., Wang, M., Ai, Y., Hou, Y., Chen, H., Lin, X., Zhang, Y., Ding, M., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109358 · Cited by 13 · see citing works

Metformin—mechanisms of its glycemia-reducing effect

Drewe, J., Foretz, M., & Krähenbühl, S. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100106 · Cited by 15 · see citing works

Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review

Geng, Y., Wang, Z., Xu, X., Sun, X., Dong, X., Luo, Y., & Sun, X. (2023) · Translational research · doi:10.1016/j.trsl.2023.08.001 · Cited by 11 · see citing works

Synthesis of Protoberberine Alkaloids by C–H Functionalization and Anionic Aza-6π-Electrocyclization: Dual Activity as AMPK Activators and Inhibitors

Cao, Y., Perry, J. S. M., Zhang, E., Trinh, A. R., Kacker, A., Cruz, S., CEBALLOS, H. M., Pan, A., Huang, W., & Kou, K. G. M. (2025) · JACS Au · doi:10.1021/jacsau.5c00047 · Cited by 11 · see citing works

Metformin as a potential treatment for COVID-19

McCarthy, M. W. (2023) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2023.2215385 · Cited by 11 · see citing works

AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury

Yin, X., Guo, Z., & Song, C. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09050-8 · Cited by 10 · see citing works

Cryptotanshinone promotes brown fat activity by AMPK activation to inhibit obesity

Ni, J., Ye, A., Gong, L., Zhao, X., Fu, S., & Guo, J. (2024) · Nutrition Research and Practice · doi:10.4162/nrp.2024.18.4.479 · Cited by 9 · see citing works

Treatment of obesity-related diabetes: significance of thermogenic adipose tissue and targetable receptors

Pan, R., Liu, J., & Chen, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1144918 · Cited by 9 · see citing works

Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice

Wang, Y., Ran, L., Zhang, F., Li, H., Cha, Q., Yang, K., Wang, H., Wu, Y., & Yu, Z. (2024) · Metabolism Open · doi:10.1016/j.metop.2024.100326 · Cited by 8 · see citing works

Bariatric surgery promotes recruitment of brown fat linked to alterations in the gut microbiota

Herz, C. T., Kulterer, O. C., Prager, M., Marculescu, R., Prager, G., Kautzky‐Willer, A., Hacker, M., Trajanoski, S., Köfeler, H. C., Gallé, B., et al. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf081 · Cited by 8 · see citing works

Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity

Liang, G., Fang, J., Zhang, P., Ding, S., Zhao, Y., & Feng, Y. (2024) · Open Medicine · doi:10.1515/med-2024-0900 · Cited by 7 · see citing works

Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice

Feng, J. N., Shao, W., Yang, L., Pang, J., Ling, W., Liu, D., Wheeler, M. B., He, H. H., & Jin, T. (2025) · Nutrition and Diabetes · doi:10.1038/s41387-025-00363-0 · Cited by 7 · see citing works

Blueberry Anthocyanins Ameliorate Obesity‐Induced Dysfunction of Lipid Metabolism and Gut Microbiota by Inhibiting TLR4 Pathway

Zhao, X., Zheng, J., Tu, Z., Li, X., Li, B., & Huang, W. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70244 · Cited by 8 · see citing works

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

Scheidemantle, G. M., Duan, L., Lodge, M., Cummings, M. J., Hilovsky, D. L., Pham, E., Wang, X., Kennedy, A. J., & Liu, X. (2024) · Metabolomics · doi:10.1007/s11306-024-02113-2 · Cited by 7 · see citing works

Fecal Microbiota Transfer from Young Mice Reverts Vascular Aging Hallmarks and Metabolic Impairments in Aged Mice

Cheng, C. K., Gao, J., Kang, L., & Huang, Y. (2024) · Aging and Disease · doi:10.14336/ad.2024.0384 · Cited by 6 · see citing works

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Fang, Z., Fan, M., Yuan, D., Jin, L., Wang, Y., Ding, L., Xu, S., Tu, J., Zhang, E., Wu, X., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04483-0 · Cited by 6 · see citing works

Changes of gut mycobiota in the third trimester of pregnant women with preeclampsia

Zou, H., Zou, W., Li, Q., Chen, Z., Shi, Y., & Li, C. (2023) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2023.2228964 · Cited by 6 · see citing works

A gut feeling for drugs that have metabolic benefits

Zhang, E., Agua, A., & Huang, W. (2023) · Nature Communications · doi:10.1038/s41467-023-40167-3 · Cited by 6 · see citing works

Graphene-Based Far-Infrared Therapy Promotes Adipose Tissue Thermogenesis and UCP1 Activation to Combat Obesity in Mice

Zhang, J., Li, S., Cheng, X., Tan, X. W., Shi, Y., Su, G., Huang, Y., Zhang, Y., Xue, R., Li, J., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052225 · Cited by 5 · see citing works

Loganin regulates glycolipid metabolism by influencing intestinal microbiota and AMPK signaling in obese mice

Xu, B., Ye, Z., Tian, T., Zhu, R., Liu, C., Fang, X., Zhang, D., Fu, M., Gao, S., & Zhao, D. (2022) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2022.06.012 · Cited by 5 · see citing works

Mapping the current research landscape of metformin in cancer based on bibliometric analysis

Wang, Y., He, S., Li, Z., Jiang, N., & Sun, G. (2025) · Discover Oncology · doi:10.1007/s12672-025-03327-z · Cited by 4 · see citing works

Meeting metformin again for the first time

Green, D. R. (2024) · Science Advances · doi:10.1126/sciadv.adu7436 · Cited by 4 · see citing works

Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging

Li, J., Song, J., Yan, B., Wu, H., Banerjee, M., Magnuson, L., Liu, Y., Zhang, S., Liu, J., Wang, C., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01461-w · Cited by 4 · see citing works

Eurotium Cristatum fermented instant dark tea prevents obesity and promotes adipose thermogenesis via modulating the gut microbiota

Wang, X., Li, Y., Yu, P., Zhang, L., Wang, Y., Yang, X., & Ren, D. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116969 · Cited by 4 · see citing works

Pharmacomicrobiomics: Exploring the role of gut microbiota in type 2 diabetes and antidiabetic drug mechanisms

Wen, D., Wang, X. G., He, Y., Hao, X., Huang, W., Zhou, H., Zhang, W., & Li, X. (2025) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2025.104379 · Cited by 3 · see citing works

Metformin, Microbiota and Health

Paz, G. S., & Fernandes, J. (2022) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2022.00032 · Cited by 3 · see citing works

Molecular Interplay between hypertension and dyslipidemia in cardiovascular pathogenesis: toward precision-based therapeutic strategies

Cao, B., Pei, J., Kong, L., Han, Y., Yan, G., & Wang, X. P. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1783567 · Cited by 2 · see citing works

Hormone based therapy and crosstalk beyond hormones

Jin, T. (2024) · Medical Review · doi:10.1515/mr-2024-0052 · Cited by 2 · see citing works

ImmunoMet Oncogenesis: A New Concept to Understand the Molecular Drivers of Cancer

Sirajee, R., Khatib, S. E., Dieleman, L. A., Salla, M., & Baksh, S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051620 · Cited by 2 · see citing works

Unravelling the association between metformin and pan-cancers: Mendelian randomization combined with NHANES database analysis

Xiang, J.-C., An, Y., Sun, J., Xu, J., Xiong, Y., Wang, S., & Xia, Q. (2025) · Discover Oncology · doi:10.1007/s12672-025-02021-4 · Cited by 2 · see citing works

Protective Effects of a Standardized Water Extract from the Stem of Ipomoea batatas L. Against High-Fat Diet-Induced Obesity

Lee, C.-W., Yoon, Y. S., Yoon, Y., Chung, K., Kim, M., Park, G., Choi, M., Jang, Y. P., & Lee, K. (2025) · Nutrients · doi:10.3390/nu17101643 · Cited by 1 · see citing works

Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications

Wang, Y., Zhang, K. X., Kan, C., Zhang, W., Sun, X., & Li, L. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70613 · Cited by 1 · see citing works

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Sun, Y. W., Zhang, M., Wang, X., Huang, X., Yu, Y., Pan, H., Li, H., Shi, L., Yang, W., Zhang, C., et al. (2026) · Integrative Zoology · doi:10.1111/1749-4877.70092 · Cited by 1 · see citing works

Gut microbiota as a novel therapeutic target for eating disorders and obesity

Samulenaite, S., Mathis, V., Darcq, E., Burokas, A., Martín‐García, E., & Maldonado, R. J. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70547 · Cited by 1 · see citing works

Improvement of Glycemic Control by Metformin Is Associated With Frequency of Defecation Before Treatment in Patients With Type 2 Diabetes Mellitus

Hieshima, K., Sugiyama, S., Yoshida, A., Kurinami, N., Suzuki, T., Otsuka, K., MIYAMOTO, F., Kajiwara, K., Jinnouchi, K., Jinnouchi, T., et al. (2023) · Journal of Endocrinology and Metabolism · doi:10.14740/jem916 · Cited by 1 · see citing works

Gut Microbiome and Brown Adipose Tissue

Moreno‐Navarrete, J. M. (2023) · Endocrinology · doi:10.1007/978-3-031-08115-6_6-1

Gut Microbiome and Brown Adipose Tissue

Moreno‐Navarrete, J. M. (2024) · Endocrinology · doi:10.1007/978-3-031-35064-1_6

Contrasting Effects of Different Oxygen Contents on Obesity, Short-Chain Fatty Acids and Proteins Expression Related to Lipid Metabolic in MicePreprint

Yan, X., Du, W., Dong, S., Ailizire, A., Li, S., Wu, Z., Ma, Y., & Wang, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4869475

Einflussfaktoren auf das gastrointestinale Mikrobiom

Macke, L., & Vasapolli, R. (2024) · Springer eBooks · doi:10.1007/978-3-662-68455-9_7

AdipoR2 enhances adipocyte thermogenesis in Tibetan pigs via AMPK-ACC signaling

Liu, S., Yang, Z., Yang, Y., Cai, Y., & Zhao, S. (2025) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2025.104209

Additional file 1 of Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5-HT pathway

Li, S., Li, X., Wang, K., Li, Y., Nagaoka, K., & Li, C. (2023) · Figshare · doi:10.6084/m9.figshare.24892819

Additional file 3 of Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5-HT pathway

Li, S., Li, X., Wang, K., Li, Y., Nagaoka, K., & Li, C. (2024) · Figshare · doi:10.6084/m9.figshare.26657248

Additional file 2 of Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5-HT pathway

Li, S., Li, X., Wang, K., Li, Y., Nagaoka, K., & Li, C. (2024) · Figshare · doi:10.6084/m9.figshare.24892936

The role of combined Metformin and pharmaceutical molecules with anti-androgenic properties in the therapy of PCOS in adult women

Antoniou-Tsigkos, A., Καρράς, Γ., Papagianni, M., CHRISTOPOULOS, P. F., Vlahos, N. F., & Mastorakos, G. M. (2025) · Endocrine · doi:10.1007/s12020-025-04527-x

Tissus adipeux brun et beige : exploration et rôle dans la physiologie humaine

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Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis

Tsironikos, G. I., Zakynthinos, G. Ε., Kyprianidou, D., Rammou, V., Antonogiannis, T., Bargiota, Α., Zakynthinos, E. G., & Tsolaki, V. (2026) · World Journal of Cardiology · doi:10.4330/wjc.v18.i4.115712

Unearthing the bioactive properties of potato ( Solanum tuberosum ) for improving metabolic health

Iniguez, A. B., Sun, Q., Du, ‬., & Zhu, M. J. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2662981

Toward a gut-AMPK axis: the microbiome and AMPK signaling in nutrition and healthy aging

Dassoff, E. S., Islam, H., & Allen, J. M. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1861013

The coordinated actions of metformin in the intestine and liver improves hyperglycemia

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AMPK and macrophage crosstalk in diabetes: Mechanisms, inflammation, and therapeutic perspectives

Ahmad, I., Zia, M. A., Tavares, R. G., Spanevello, R. M., & Stefanello, F. M. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.08.002

AMPK Therapy—A Little Goes A Long Way

CEBALLOS, H. M., Eryun, Z., & Huang, W. (2026) · Cells · doi:10.3390/cells15161503

The AMPK signaling pathway in cell metabolism and human diseases

Zhang, Z., Gu, Y., He, H., Qiao, S., Shao, Y., 龙先铭, Huang, J., Zhang, L., & Zhou, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02790-6

Dietary Polysaccharides for Overweight and Obesity Management: Targeting AMPK via the Gut Microbiota and Metabolites—A Review

Chu, Z., Hu, Z., Zhu, B., Luo, F., Zhou, Y., & Lin, Q. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag161

Intestinal AMPK modulation of gut microbiota mediates cross‐talk with brown fat to control metabolism

Huang, W., Zhang, E., Jin, L., Wang, Y., Fang, Z., Al-Abdullah, I. H., & Shuck, S. C. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r4074

2042-LB: The Gut–Fat Cross Talk in Metabolic Regulation through Microbiome

Zhang, E., CEBALLOS, H. M., & Huang, W. (2024) · Diabetes · doi:10.2337/db24-2042-lb

Metabolic regulation by the intestinal metformin-AMPK axis

Zhang, S., & Lam, T. K. T. (2022) · Nature Communications · doi:10.1038/s41467-022-30477-3 · Cited by 18 · see citing works

228-LB: Metformin Alleviates Aging-Associated Metabolic Disorders through Intestinal AMPK-Mediated Gut Microbiome Alteration

Zhang, E., & Huang, W. (2023) · Diabetes · doi:10.2337/db23-228-lb · Cited by 2 · see citing works

The in vivo role of AMP-activated protein kinase in the metabolic function of brown and beige adipose tissue

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