Cited by 151Liver physiology and pathologyDrug Transport and Resistance MechanismsFibroblast Growth Factor Research

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice

Open access
Zhang, Lisheng, Wang, Yan-Dong, Chen, Wei-Dong, Wang, Xichun, Lou, Guiyu, Liu, Nian, Lin, Min, Forman, Barry M. +1 more·2012·Hepatology

Abstract

UNLABELLED: Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is the primary bile acid receptor. We previously showed that FXR was required for the promotion of liver regeneration/repair after physical resection or liver injury. However, the mechanism by which FXR promotes liver regeneration/repair is still unclear. Here we show that both hepatic-FXR and intestine-FXR contributed to promote liver regeneration/repair after either 70% partial hepatectomy or carbon tetrachloride-induced liver injury. Hepatic FXR, but not intestine FXR, is required for the induction of Foxm1b gene expression in liver during liver regeneration/repair. In contrast, intestine FXR is activated to induce FGF15 expression in intestine after liver damage. Ectopic expression of FGF15 was able to rescue the defective liver regeneration/repair in intestine-specific FXR null mice. CONCLUSION: These results demonstrate that, in addition to the cell-autonomous effect of hepatic FXR, the endocrine FGF15 pathway activated by FXR in intestine also participates in the promotion of liver regeneration/repair.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/hep.25905

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [15]Kim I Ahn SH Inagaki T Choi M Ito S Guo GL Kliewer SA Gonzalez FJ Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine J Lipid Res 2007 48 2664 2672 17720959
  2. [28]Lu TT Makishima M Repa JJ Schoonjans K Kerr TA Auwerx J Mangelsdorf DJ Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Cell 2000 6 507 515 11030331

Cited by

Sorted by citations

Authors
Zhang, L., Wang, Y.-D., Chen, W.-D., Wang, X., Lou, G., Liu, N., Lin, M., Forman, B. M., & Huang, W.
Affiliations
City Of Hope National Medical Center (US)
Corresponding author
Huang, Wendong
Venue
Hepatology
Published
2012-12
Volume
56
Issue
6
Pages
2336-2343
ISSN
0270-9139 (ISSN-L)
OpenAlex
W2167120766
Cited by
151
References
38
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 20 · 2020: 12 · 2019: 7 · 2018: 16 · 2017: 13 · 2016: 7 · 2015: 13 · 2014: 18 · 2013: 8 · 2012: 3
FWCI
8.52
Type
journal article
Language
en
Open access
Locations
  • Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • U.S. Public Health Service (R01-139158)
  • National Cancer Institute (R01CA139158)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords
farnesoid X receptor, liver regeneration, liver repair, partial hepatectomy, carbon tetrachloride-induced liver injury, FoxM1B, FGF15, hormone signaling, bile acid receptors, gut-liver axis
MeSH terms
Receptor, Farnesoid X-Activated, Analysis of Variance, Animals, Bile Acids and Salts, Carbon Tetrachloride, Cholesterol 7-alpha-Hydroxylase, Fibroblast Growth Factors, Gene Expression Regulation, Hepatectomy, Intestinal Mucosa, Liver, Liver Regeneration, Male, Necrosis, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Mice, Knockout, Mice, Chemical and Drug Induced Liver Injury

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review