Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice
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UNLABELLED: Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is the primary bile acid receptor. We previously showed that FXR was required for the promotion of liver regeneration/repair after physical resection or liver injury. However, the mechanism by which FXR promotes liver regeneration/repair is still unclear. Here we show that both hepatic-FXR and intestine-FXR contributed to promote liver regeneration/repair after either 70% partial hepatectomy or carbon tetrachloride-induced liver injury. Hepatic FXR, but not intestine FXR, is required for the induction of Foxm1b gene expression in liver during liver regeneration/repair. In contrast, intestine FXR is activated to induce FGF15 expression in intestine after liver damage. Ectopic expression of FGF15 was able to rescue the defective liver regeneration/repair in intestine-specific FXR null mice. CONCLUSION: These results demonstrate that, in addition to the cell-autonomous effect of hepatic FXR, the endocrine FGF15 pathway activated by FXR in intestine also participates in the promotion of liver regeneration/repair.
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FXR facilitates liver regeneration via induction of Foxm1.
“whereas FXR facilitates liver regeneration via induction of Foxm1.5,60, 61, 62, 63”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [61]
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Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,057 · see citing works
Higgins, G. (1931) · Cited by 2,444 · see citing works
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865 · see citing works
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678 · see citing works
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567 · see citing works
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487 · see citing works
Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K., Donahee, M. H., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., et al. (2003) · Genes & Development · doi:10.1101/gad.1083503 · Cited by 698 · see citing works
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science · doi:10.1126/science.1121435 · Cited by 645 · see citing works
Self-citationFarnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
Wang, Y.-D., Chen, W.-D., Wang, M., Yu, D., Forman, B. M., & Huang, W. (2008) · Hepatology · doi:10.1002/hep.22519 · Cited by 639 · see citing works
Self-citationKim, I., Ahn, S.-H., Inagaki, T., Choi, M., Ito, S., Guo, G. L., Kliewer, S., & Gonzalez, F. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700330-jlr200 · Cited by 575 · see citing works
Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., & Huang, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1078 · Cited by 488 · see citing works
Self-citationRedundant Pathways for Negative Feedback Regulation of Bile Acid Production
Wang, L., Lee, Y., Bundman, D. S., Han, Y., Thevananther, S., Kim, C.-S., Chua, S. S., Wei, P. Y., Heyman, R. A., Karin, M., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00187-9 · Cited by 475 · see citing works
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
Kim, I., Morimura, K., Shah, Y., Yang, Q., Ward, J. M., & Gonzalez, F. J. (2007) · Carcinogenesis · doi:10.1093/carcin/bgl249 · Cited by 357 · see citing works
Gupta, S., Stravitz, R. T., Dent, P., & Hylemon, P. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010878200 · Cited by 322 · see citing works
Schaap, F. G., Gaag, N. A. V. D., Gouma, D. J., & Jansen, P. L. M. (2008) · Hepatology · doi:10.1002/hep.22771 · Cited by 279 · see citing works
Modica, S., Petruzzelli, M., Bellafante, E., Murzilli, S., Salvatore, L., Celli, N., Di Tullio, G., Palasciano, G., Moustafa, T., Halilbasic, E., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.028 · Cited by 275 · see citing works
Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260 · see citing works
Qiao, L., Studer, E., Leach, K., McKinstry, R., Gupta, S., Decker, R., Kukreja, R., Valerie, K., Nagarkatti, P., El-Deiry, W., et al. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2629 · Cited by 242 · see citing works
FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation
Wu, X., Ge, H., Lemon, B., Vonderfecht, S., Weiszmann, J., Hecht, R., Gupte, J., Hager, T., Wang, Z.-L., Lindberg, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068783 · Cited by 186 · see citing works
Li, T., Jahan, A., & Chiang, J. Y. L. (2006) · Hepatology · doi:10.1002/hep.21183 · Cited by 169 · see citing works
Animal models of liver regeneration
Palmes, D., & Spiegel, H.-U. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00508-8 · Cited by 165 · see citing works
Miyake, J. H., Wang, S.-L., & Davis, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000275200 · Cited by 163 · see citing works
Kullak-Ublick, G. A., & Meier, P. J. (2000) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70114-8 · Cited by 129 · see citing works
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.
Yu, C., Wang, F., Jin, C., Wu, X.-C., Chan, W.-K., & Mckeehan, W. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64478-1 · Cited by 128 · see citing works
Miao, J., Xiao, Z., Kanamaluru, D., Min, G., Yau, P. M., Veenstra, T. D., Ellis, E. C. S., Strom, S., Suino-Powell, K. M., Xu, H. E., et al. (2009) · Genes & Development · doi:10.1101/gad.1773909 · Cited by 126 · see citing works
Chen, W.-D., Wang, Y.-D., Zhang, L., Shiah, S., Wang, M., Yang, F., Yu, D., Forman, B. M., & Huang, W. (2010) · Hepatology · doi:10.1002/hep.23390 · Cited by 115 · see citing works
Self-citationFXR Regulates Liver Repair after CCl4-Induced Toxic Injury
Meng, Z., Wang, Y., Wang, L., Jin, W., Liu, N., Pan, H., Liu, L., Wagman, L. D., FORMAN, B. M., & Huang, W. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0286 · Cited by 113 · see citing works
Self-citationFGF15/FGFR4 Integrates Growth Factor Signaling with Hepatic Bile Acid Metabolism and Insulin Action
Shin, D.-J., & Osborne, T. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808747200 · Cited by 111 · see citing works
Significance and Mechanism of CYP7a1 Gene Regulation during the Acute Phase of Liver Regeneration
Zhang, L., Huang, X., Meng, Z., Dong, B., Shiah, S., Moore, D. D., & Huang, W. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0198 · Cited by 89 · see citing works
Self-citationA Rat Model of Chronic Postinflammatory Visceral Pain Induced by Deoxycholic Acid
Traub, R. J., Tang, B., Ji, Y., Pandya, S., Yfantis, H. G., & Sun, Y. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.08.051 · Cited by 83 · see citing works
Song, K. H., Ellis, E. C. S., Strom, S. C., & Chiang, J. Y. L. (2007) · Hepatology · doi:10.1002/hep.21878 · Cited by 68 · see citing works
Wang, Y.-D., Yang, F., Chen, W.-D., Huang, X.-F., Lai, L., Forman, B. M., & Huang, W.-D. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0527 · Cited by 61 · see citing works
Self-citationGutierrez, A., Ratliff, E. P., Andres, A. M., Huang, X., McKeehan, W. L., & Davis, R. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000195793.73118.b4 · Cited by 59 · see citing works
Nuclear bile acid receptor FXR in the hepatic regeneration
Chen, W., Wang, Y., Meng, Z., Zhang, L., & Huang, W. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.006 · Cited by 56 · see citing works
Self-citationLiver X Receptor and Farnesoid X Receptor as Therapeutic Targets
Rader, D. J. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.08.008 · Cited by 53 · see citing works
Norberg, R., Lidman, K., & Fagraeus, A. (1975) · Cell · doi:10.1016/0092-8674(75)90039-2 · Cited by 37 · see citing works
Shin, D.-J., & Osborne, T. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710452200 · Cited by 28 · see citing works
A liver revival featuring bile acids
Houten, S. M. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.12.005 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [15]Kim I Ahn SH Inagaki T Choi M Ito S Guo GL Kliewer SA Gonzalez FJ Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine J Lipid Res 2007 48 2664 2672 17720959
- [28]Lu TT Makishima M Repa JJ Schoonjans K Kerr TA Auwerx J Mangelsdorf DJ Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Cell 2000 6 507 515 11030331
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Chávez-Talavera, O., Tailleux, A., Lefebvre, P., & Staels, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.055 · Cited by 970 · see citing works
Molecular physiology of bile acid signaling in health, disease, and aging
Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481 · see citing works
Bile acid nuclear receptor FXR and digestive system diseases
Ding, L., Yang, L., Wang, Z., & Huang, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.004 · Cited by 477 · see citing works
Self-citationBile acid transporters and regulatory nuclear receptors in the liver and beyond
Halilbasic, E., Claudel, T., & Trauner, M. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.002 · Cited by 397 · see citing works
Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer
Li, T., & Apte, U. M. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.003 · Cited by 335 · see citing works
Update on FXR Biology: Promising Therapeutic Target?
Han, C. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072069 · Cited by 185 · see citing works
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 183 · see citing works
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works
Understanding Liver Regeneration
Gilgenkrantz, H., & Collin de l'Hortet, A. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.03.008 · Cited by 171 · see citing works
Zheng, Z., & Wang, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775526 · Cited by 168 · see citing works
Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
Anwar, S., Shamsi, A., Mohammad, T., Islam, A., & Hassan, M. I. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188568 · Cited by 165 · see citing works
Elucidating the Metabolic Regulation of Liver Regeneration
Huang, J., & Rudnick, D. A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.04.034 · Cited by 149 · see citing works
Implications of microbiota and bile acid in liver injury and regeneration
Liu, H., Keane, R., Sheng, L., & Wan, Y. Y. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.001 · Cited by 145 · see citing works
Degirolamo, C., Modica, S., Vacca, M., Di Tullio, G., Morgano, A., D'Orazio, A., Kannisto, K., Parini, P., & Moschetta, A. (2015) · Hepatology · doi:10.1002/hep.27274 · Cited by 121 · see citing works
Fibroblast Growth Factor 15/19: From Basic Functions to Therapeutic Perspectives
Somm, E., & Jornayvaz, F. R. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00134 · Cited by 118 · see citing works
Bile acid signaling and liver regeneration
Fan, M., Wang, X., Xu, G., Yan, Q., & Huang, W. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.021 · Cited by 110 · see citing works
Self-citationTissue-specific actions of FXR in metabolism and cancer
Gadaleta, R. M., Cariello, M., Sabbà, C., & Moschetta, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.005 · Cited by 110 · see citing works
Nuclear bile acid signaling through the farnesoid X receptor
Mazuy, C., Helleboid, A., Staels, B., & Lefebvre, P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1805-y · Cited by 111 · see citing works
The gut microbiome-bile acid axis in hepatocarcinogenesis
Wu, L., Feng, J., Li, J., Yu, Q., Ji, J., Wu, J., Dai, W., & Guo, C. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111036 · Cited by 103 · see citing works
Cariello, M., Piccinin, E., García‐Irigoyen, O., Sabbà, C., & Moschetta, A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.019 · Cited by 97 · see citing works
Padrissa‐Altés, S., Bachofner, M., Bogorad, R. L., Pohlmeier, L. M., Rossolini, T., Böhm, F., Liebisch, G., Hellerbrand, C., Koteliansky, V., Speicher, T., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307874 · Cited by 98 · see citing works
Huang, X., Zhao, W., & Huang, W. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.117 · Cited by 95 · see citing works
Self-citationBile Acid Receptors and Liver Cancer
Wang, X., Fu, X., Ness, C. V., Meng, Z., Ma, X., & Huang, W. (2012) · Current Pathobiology Reports · doi:10.1007/s40139-012-0003-6 · Cited by 91 · see citing works
Self-citationKietzmann, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092347 · Cited by 90 · see citing works
Ileal FGF 15 contributes to fibrosis‐associated hepatocellular carcinoma development
Uriarte, I., Latasa, M. U., Carotti, S., Fernández‐Barrena, M. G., García‐Irigoyen, O., Elizalde, M., Urtasun, R., Gentilucci, U. V., Morini, S., Pulido, Á. D. M., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29287 · Cited by 88 · see citing works
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
Erice, O., Labiano, I., Arbelaiz, A., Santos‐Laso, Á., Muñoz-Garrido, P., Jiménez-Agüero, R., Olaizola, P., Caro‐Maldonado, A., Martín-Martín, N., Carracedo, A., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.016 · Cited by 79 · see citing works
Role of Bile Acids in Liver Injury and Regeneration following Acetaminophen Overdose
Bhushan, B., Borude, P., Edwards, G., Walesky, C., Cleveland, J., Li, F., Ma, X., & Apte, U. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.07.012 · Cited by 79 · see citing works
Host Transcription Factors in Hepatitis B Virus RNA Synthesis
Turton, K. L., Meier‐Stephenson, V., Badmalia, M. D., Coffin, C. S., & Patel, T. R. (2020) · Viruses · doi:10.3390/v12020160 · Cited by 77 · see citing works
Jung, K., Kim, M., So, J., Lee, S., Ko, S., & Shin, D. (2020) · Hepatology · doi:10.1002/hep.31679 · Cited by 80 · see citing works
Gu, M., Zhao, P., Huang, J.-W., Zhao, Y., Wang, Y.-H., Li, Y., Li, Y.-F., Fan, S., Ma, Y.-M., Tong, Q., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00345 · Cited by 76 · see citing works
Self-citationXu, M., Shen, Y. S., Cen, M., Zhu, Y., Cheng, F., Tang, L., Zheng, X., Kim, J. J., Dai, N., & Hu, W. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab003 · Cited by 71 · see citing works
Bile Acid Flux Is Necessary for Normal Liver Regeneration
Naugler, W. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097426 · Cited by 65 · see citing works
Cellular and molecular basis of liver regeneration
Bangru, S., & Kalsotra, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.004 · Cited by 66 · see citing works
Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, and cancerous diseases
Li, X., Lu, W., Kharitonenkov, A., & Luo, Y. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13767 · Cited by 60 · see citing works
Wang, Y., Li, J., Matye, D. J., Zhang, Y., Dennis, K. L., Ding, W., & Li, T. (2018) · JCI Insight · doi:10.1172/jci.insight.99676 · Cited by 58 · see citing works
Self-citationJia, Y., Viswakarma, N., & Reddy, J. K. (2014) · Gene Expression · doi:10.3727/105221614x13919976902219 · Cited by 54 · see citing works
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Rodrigues, S. G., der Merwe, V., Krag, A. A., & Wiest, R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2023.101859 · Cited by 51 · see citing works
Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications
Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Jiménez, M., Bárcena‐Varela, M., Santamaría, E., Urtasun, R., Rodríguez‐Ortigosa, C. M., Prìeto, J., Berraondo, P., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.025 · Cited by 50 · see citing works
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands
Carotti, A., Marinozzi, M., Custodi, C., Cerra, B., Pellicciari, R., Gioiello, A., & Macchiarulo, A. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026614666141112094058 · Cited by 50 · see citing works
Kainuma, M., Takada, I., Makishima, M., & Sano, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071898 · Cited by 49 · see citing works
Olthof, P. B., Coelen, R. J. S., Wiggers, J. K., Besselink, M. G., Busch, O. R., & van Gulik, T. M. (2016) · HPB · doi:10.1016/j.hpb.2015.11.007 · Cited by 48 · see citing works
Bile acids and their receptors during liver regeneration: “Dangerous protectors”
Merlen, G., Bedoya, J. U., Bidault, V., Kahale, N., Glénisson, M., Doignon, I., Rainteau, D. P., & Tordjmann, T. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.002 · Cited by 48 · see citing works
Ma, J., Ding, J., Zhao, H. L., & Liu, C. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12245 · Cited by 48 · see citing works
Ding, L., Zhang, E., Yang, Q., Jin, L., Sousa, K. M., Dong, B., Wang, Y., Tu, J., Ma, X., Tian, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019388118 · Cited by 47 · see citing works
Self-citationDark and bright side of targeting fibroblast growth factor receptor 4 in the liver
Gadaleta, R. M., & Moschetta, A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.029 · Cited by 46 · see citing works
Lü, W., Cheng, F., Jiang, J., Zhang, C., Deng, X., Xu, Z., Zou, S., Shen, X., Tang, Y., & Huang, J. Y. (2015) · Scientific Reports · doi:10.1038/srep08114 · Cited by 46 · see citing works
The role of bile salts in liver regeneration
van de Laarschot, L. F. M., Jansen, P. L. M., Schaap, F. G., & Damink, S. W. M. O. (2016) · Hepatology International · doi:10.1007/s12072-016-9723-8 · Cited by 45 · see citing works
Novel bile acid therapeutics for the treatment of chronic liver diseases
Hegade, V. S., Speight, A., Etherington, R. E., & Jones, D. E. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16630712 · Cited by 44 · see citing works
van Golen, R. F., Olthof, P. B., Lionarons, D. A., Reiniers, M. J., Alles, L. K., Uz, Z., de Haan, L. R., Ergin, B., de Waart, D. R., Maas, M. A. W., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33070-1 · Cited by 44 · see citing works
Bile acid homeostasis in gastrointestinal and metabolic complications of cystic fibrosis
van de Peppel, I. P., Bodewes, F. A. J. A., Verkade, H. J., & Jonker, J. W. (2018) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2018.08.009 · Cited by 43 · see citing works
Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.
Xu, J.-Y., Li, Z.-P., Zhang, L., & Ji, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i37.13493 · Cited by 37 · see citing works
Xie, G., Yin, S., Zhang, Z., Qi, D., Wang, X., Kim, D., Yagai, T., Brocker, C. N., Wang, Y., Gonzalez, F. J., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.10.009 · Cited by 40 · see citing works
Self-citationMeng, Q., Chen, X., Wang, C., Liu, Q., Sun, H., Sun, P., Huo, X., Liu, Z., & Liu, K. (2015) · Food & Function · doi:10.1039/c5fo00082c · Cited by 39 · see citing works
Hendriks, D. F. G., Artegiani, B., Margaritis, T., Zoutendijk, I., Lopes, S. M. C. D. S., & Clevers, H. C. (2024) · Nature Communications · doi:10.1038/s41467-024-48550-4 · Cited by 39 · see citing works
Meng, Q., Chen, X., Wang, C., Liu, Q., Sun, H., Sun, P., Peng, J., & Liu, K. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.09.009 · Cited by 38 · see citing works
Ouyang, Q., Lin, X., Zhu, Y., Zheng, B. J., Liang, L., Yang, Y., Hou, G., Chen, X., Luo, G., Huo, F., et al. (2017) · Hepatology · doi:10.1002/hep.29562 · Cited by 37 · see citing works
Wang, C., Zhang, F., Wang, L., Zhang, Y., Li, X., Huang, K., Du, M., Liu, F., Huang, S., Guan, Y., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00160-13 · Cited by 37 · see citing works
The Bile Acid Receptor TGR5 and Liver Regeneration
Bidault, V., Pean, N., Doignon, I., Humbert, L., Rainteau, D. P., & Tordjmann, T. (2015) · Digestive Diseases · doi:10.1159/000371668 · Cited by 35 · see citing works
de Haan, L. R., van der Lely, S. J., Warps, A. K., Hofsink, Q., Olthof, P. B., de Keijzer, M. J., Lionarons, D. A., Dias, L. M., Bruinsma, B. G., Uygun, K., et al. (2018) · Journal of Clinical and Translational Research · doi:10.18053/jctres.04.201801.001 · Cited by 33 · see citing works
Gao, X., Fu, T., Wang, C., Ning, C., Kong, Y., Liu, Z., Sun, H., Ma, X., Liu, K., & Meng, Q. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.09.016 · Cited by 33 · see citing works
Gao, X., Fu, T., Wang, C., Ning, C., Liu, K., Liu, Z., Sun, H., Ma, X., Huo, X., Yang, X., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.04.015 · Cited by 33 · see citing works
Cai, P., Mao, X., Zhao, J., Nie, L., Jiang, Y., Yang, Q., Ni, R., He, J., & Luo, L. (2021) · Hepatology · doi:10.1002/hep.32076 · Cited by 33 · see citing works
Carbamazepine promotes liver regeneration and survival in mice
Kawaguchi, T., Kodama, T., Hikita, H., Tanaka, S., Shigekawa, M., Nawa, T., Shimizu, S., Li, W., Miyagi, T., Hiramatsu, N., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.018 · Cited by 33 · see citing works
Cell metabolism-based therapy for liver fibrosis, repair, and hepatocellular carcinoma
Gilgenkrantz, H., Paradis, V., & Lotersztajn, S. (2023) · Hepatology · doi:10.1097/hep.0000000000000479 · Cited by 32 · see citing works
Xie, Y., Wang, H., Cheng, X., Wu, Y. C., Cao, L., Wu, M., Xie, W., Wang, G., & Hao, H. (2016) · Scientific Reports · doi:10.1038/srep18751 · Cited by 32 · see citing works
Liver organoid culture methods
Hu, Y., Hu, X., Luo, J. C., Huang, J., Sun, Y., Li, H., Qiao, Y., Wu, H., Li, J., Zhou, L., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01136-x · Cited by 33 · see citing works
Novel treatment options for portal hypertension
Schwabl, P., & Laleman, W. (2017) · Gastroenterology report · doi:10.1093/gastro/gox011 · Cited by 31 · see citing works
Wahlang, B., Alexander, N. C., Li, X., Rouchka, E. C., Kirpich, I., & Cave, M. C. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.03.010 · Cited by 31 · see citing works
Jia, L., Jiang, D., Hu, P., Li, X., Shi, H., Cheng, D., & Zhang, L. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.03.016 · Cited by 30 · see citing works
Self-citationSynthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors.
Singh, N., Yadav, M., Singh, A., Kumar, H., Dwivedi, S., Mishra, J., Gurjar, A., Manhas, A., Chandra, S., Yadav, P. N., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1353 · Cited by 31 · see citing works
Vascular targets for the treatment of portal hypertension
Brusilovskaya, K., Königshofer, P., Schwabl, P., & Reiberger, T. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1693115 · Cited by 28 · see citing works
Pastore, M., Lori, G., Gentilini, A., Taddei, M. L., Maira, G. D., Campani, C., Recalcati, S., Invernizzi, P., Marra, F., & Raggi, C. (2020) · Cells · doi:10.3390/cells9030596 · Cited by 28 · see citing works
A CK2–RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR
Bilodeau, S., Caron, V., Gagnon, J., Kuftedjian, A., & Tremblay, A. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx009 · Cited by 27 · see citing works
Wang, Z., Wang, X., Fu, L., Xu, S., Wang, X., Liao, Q., Zhuang, T., Liu, L., Zhang, H., Li, W., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155938 · Cited by 27 · see citing works
Self-citationNuclear receptors: a bridge linking the gut microbiome and the host
Wang, Z., Chen, W., & Wang, Y. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00407-y · Cited by 26 · see citing works
Self-citationLi, Q., Zhao, Q., Zhang, C., Zhang, P., Hu, A., Zhang, L., Schroder, P. M., Ma, Y., Guo, Z., Zhu, X., et al. (2018) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-018-0610-8 · Cited by 26 · see citing works
Self-citationSun, S., Zhao, B., Qi, M., Yao, Y., Xu, L., Ji, R., Chen, W., Wang, J., Huang, S., Ma, L., et al. (2019) · Shock · doi:10.1097/shk.0000000000001351 · Cited by 26 · see citing works
Self-citationThe impact of steatosis on liver regeneration
Allaire, M., & Gilgenkrantz, H. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0050 · Cited by 24 · see citing works
Mi, C., Lu, C., Lu, H., Zhang, J., Qin, D., Liu, S., Li, X., & Zhang, L. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02298-6 · Cited by 22 · see citing works
Self-citationMeacham, K. A., Cortés, M., Wiggins, E. M., Maass, A., Latorre, M., Ralle, M., & Burkhead, J. L. (2018) · Metallomics · doi:10.1039/c8mt00199e · Cited by 17 · see citing works
Olthof, P. B., Huisman, F., Schaap, F. G., van Lienden, K. P., Bennink, R. J., van Golen, R. F., Heger, M., Verheij, J., Jansen, P. L. M., Damink, S. W. M. O., et al. (2017) · British journal of surgery · doi:10.1002/bjs.10466 · Cited by 20 · see citing works
Cholic Acid Induces a Cftr Dependent Biliary Secretion and Liver Growth Response in Mice
Bodewes, F. A. J. A., Bijvelds, M. J. C., de Vries, W., Baller, J., Gouw, A., de Jonge, H. R., & Verkade, H. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117599 · Cited by 19 · see citing works
Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice
Ikpa, P. T., Doktorova, M., Meijsen, K. F., Nieuwenhuijze, N. D. A., Verkade, H. J., Jonker, J. W., de Jonge, H. R., & Bijvelds, M. J. C. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.08.006 · Cited by 19 · see citing works
Ma, J., Xia, S., Zhang, B., Luo, F., Guo, L., Yang, Y., Gong, H., & Yan, M. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154893 · Cited by 17 · see citing works
Bile acids and FGF receptors: orchestrators of optimal liver regeneration
Gilgenkrantz, H., & Tordjmann, T. (2015) · Gut · doi:10.1136/gutjnl-2014-308746 · Cited by 16 · see citing works
Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats
Ding, L., Yang, Y. Y., Qu, Y., Yang, T., Wang, K., Liu, W., & Xia, W.-B. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3270 · Cited by 16 · see citing works
Liver Regeneration in the Acute Liver Failure Patient
Wirth, K. M., Kizy, S., & Steer, C. J. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.01.004 · Cited by 16 · see citing works
Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration
Koelfat, K. V. K., van Mierlo, K. M. C., Lodewick, T. M., Bloemen, J. G., van der Kroft, G., Amygdalos, I., Neumann, U. P., Dejong, C. H. C., Jansen, P. L. M., Damink, S. W. M. O., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1728 · Cited by 15 · see citing works
Suárez, M., Martínez, R., Torres, A., Ramón, A., Blasco, P., & Mateo, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206489 · Cited by 15 · see citing works
Lgr5 + cell fate regulation by coordination of metabolic nuclear receptors during liver repair
Qin, D., Liu, S., Lu, Y., Yan, Y. L., Zhang, J., Cao, S., Chen, M., Chen, N., Huang, W., Wang, L., et al. (2022) · Theranostics · doi:10.7150/thno.74194 · Cited by 14 · see citing works
Self-citationMetabolic nuclear receptors coordinate energy metabolism to regulate Sox9+ hepatocyte fate
Liu, S., Qin, D., Yan, Y. L., Wu, J., Meng, L., Huang, W., Wang, L., Chen, X., & Zhang, L. (2021) · iScience · doi:10.1016/j.isci.2021.103003 · Cited by 14 · see citing works
Self-citationPrometheus’ little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth
Schaap, F. G., Leclercq, I. A., Jansen, P. L. M., & Damink, S. W. M. O. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.013 · Cited by 12 · see citing works
Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice
Jiang, J., Fan, M., Yuan, W., Yue, D., Wang, Z., Yang, L., Huang, W., Jin, L., Wang, X., & Ding, L. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00387.2024 · Cited by 11 · see citing works
Self-citationMicrobiome-derived bile acids as endogenous regenerative mediators in liver repair
Pandey, S. N., Goyal, K., Rana, M., Menon, S. V., Ray, S., Ali, H., Kumbhar, P., Disouza, J., Singh, S. K., Gupta, G., et al. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.08.011 · Cited by 12 · see citing works
Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits
Anaya‐Hernández, A., Méndez-Tepepa, M., Hernández-Aragón, L. G., Pacheco, P., Martı́nez–Gómez, M., Castelán, F., & Cuevas‐Romero, E. (2014) · Acta Histochemica · doi:10.1016/j.acthis.2014.05.003 · Cited by 11 · see citing works
Benjaskulluecha, S., Boonmee, A., Haque, M., Wongprom, B., Pattarakankul, T., Pongma, C., Sri-ngern-ngam, K., Keawvilai, P., Sukdee, T., Saechue, B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108733 · Cited by 10 · see citing works
Wu, D., & van de Graaf, S. F. J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116437 · Cited by 10 · see citing works
Porada, M., & Bułdak, Ł. (2025) · Metabolites · doi:10.3390/metabo15020072 · Cited by 10 · see citing works
Obeticholic Acid—A Pharmacological and Clinical Review
Keshvani, C., Kopel, J. J., & Goyal, H. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3010017 · Cited by 10 · see citing works
Dysregulation of Bile Acids in Patients with NAFLD
Zhang, X., & Deng, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81474 · Cited by 10 · see citing works
- Authors
- Zhang, L., Wang, Y.-D., Chen, W.-D., Wang, X., Lou, G., Liu, N., Lin, M., Forman, B. M., & Huang, W.
- Affiliations
- City Of Hope National Medical Center (US)
- Corresponding author
- Huang, Wendong
- ORCID
- Venue
- Hepatology
- Published
- 2012-12
- Volume
- 56
- Issue
- 6
- Pages
- 2336-2343
- ISSN
- 0270-9139 (ISSN-L)
- PMC
- PMC3477501
- OpenAlex
- W2167120766
- Cited by
- 151
- References
- 38
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 20 · 2020: 12 · 2019: 7 · 2018: 16 · 2017: 13 · 2016: 7 · 2015: 13 · 2014: 18 · 2013: 8 · 2012: 3
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (R01-139158)
- National Cancer Institute (R01CA139158)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- farnesoid X receptor, liver regeneration, liver repair, partial hepatectomy, carbon tetrachloride-induced liver injury, FoxM1B, FGF15, hormone signaling, bile acid receptors, gut-liver axis
- MeSH terms
- Receptor, Farnesoid X-Activated, Analysis of Variance, Animals, Bile Acids and Salts, Carbon Tetrachloride, Cholesterol 7-alpha-Hydroxylase, Fibroblast Growth Factors, Gene Expression Regulation, Hepatectomy, Intestinal Mucosa, Liver, Liver Regeneration, Male, Necrosis, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Mice, Knockout, Mice, Chemical and Drug Induced Liver Injury
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