Cuppen, Edwin

Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF

Schuijers, J., Mokry, M., Hatzis, P., Cuppen, E., & Clevers, H. (2014) · The EMBO Journal

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 191

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

Westendorp, B., Mokry, M., Groot Koerkamp, M. J. A., Holstege, F. C. P., Cuppen, E., & de Bruin, A. (2012) · Nucleic Acids Research

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 125

The mutational impact of culturing human pluripotent and adult stem cells

Kuijk, E., Jager, M., van der Roest, B., Locati, M. D., Van Hoeck, A., Korzelius, J., Janssen, R., Besselink, N., Boymans, S., van Boxtel, R., et al. (2020) · Nature Communications

Pluripotent Stem Cells ResearchCancer Genomics and Diagnostics

Cited by 124

Repertoire and evolution of miRNA genes in four divergent nematode species

de Wit, E., Linsen, S. E. V., Cuppen, E., & Berezikov, E. (2009) · Genome Research

MicroRNA in disease regulationChromosomal and Genetic Variations

Cited by 121

Portrait of a cancer: mutational signature analyses for cancer diagnostics

Van Hoeck, A., Tjoonk, N. H., van Boxtel, R., & Cuppen, E. (2019) · BMC Cancer

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 107

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer

Rosendahl Huber, A., Pleguezuelos-Manzano, C., Puschhof, J., Ubels, J., Boot, C., Saftien, A., Verheul, M., Trabut, L. T., Groenen, N., van Roosmalen, M., et al. (2024) · Cancer Cell

Genetic factors in colorectal cancerCancer Genomics and Diagnostics

Cited by 106

Genomic landscape of rat strain and substrain variation

Hermsen, R., de Ligt, J., Spee, W., Blokzijl, F., Schäfer, S., Adami, E., Boymans, S., Flink, S., van Boxtel, R., van der Weide, R. H., et al. (2015) · BMC Genomics

Genomics and Phylogenetic StudiesGenetic Mapping and Diversity in Plants and Animals

Cited by 93

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., et al. (2020) · Scientific Reports

Pediatric Hepatobiliary Diseases and TreatmentsLiver physiology and pathology

Cited by 86

Haplotype Block Structure Is Conserved across Mammals

Guryev, V., Smits, B. M. G., de Belt, J. V., Verheul, M., Hubner, N., & Cuppen, E. (2006) · PLoS Genetics

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 69

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

Jager, M., Blokzijl, F., Sasselli, V., Boymans, S., Janssen, R., Besselink, N., Clevers, H., van Boxtel, R., & Cuppen, E. (2018) · Nature Protocols

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 66

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

Ressa, A., Bosdriesz, E., de Ligt, J., Mainardi, S., Maddalo, G., Prahallad, A., Jager, M., de la Fonteijne, L., Fitzpatrick, M., Groten, S., et al. (2018) · Molecular & Cellular Proteomics

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 17