Cuppen, Edwin

Organoid models of human and mouse ductal pancreatic cancer

Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 2,150

A living biobank of breast cancer organoids captures disease heterogeneity

Sachs, N., de Ligt, J., Kopper, O., Gogola, E., Bounova, G., Weeber, F., Balgobind, A. V., Wind, K., Gracanin, A., Begthel, H., et al. (2018) · Cell

Cancer Cells and MetastasisBreast Cancer Treatment Studies

Cited by 1,973

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., et al. (2015) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 1,619

SARS-CoV-2 productively infects human gut enterocytes

Lamers, M. M., Beumer, J., van der Vaart, J., Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Paul van Schayck, J., Mykytyn, A. Z., Duimel, H. Q., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,573

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Schwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 1,424

Phylogenetic Shadowing and Computational Identification of Human microRNA Genes

Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. H. A., & Cuppen, E. (2005) · Cell

MicroRNA in disease regulationChromosomal and Genetic Variations

Cited by 1,270

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A., van Hoeck, A., Wood, H. M., Nomburg, J., Gurjao, C., Manders, F., Dalmasso, G., Stege, P. B., et al. (2020) · Nature

Genetic factors in colorectal cancerCancer Genomics and Diagnostics

Cited by 1,208

Pan-cancer whole-genome analyses of metastatic solid tumours

Priestley, P., Baber, J., Lolkema, M. P., Steeghs, N., de Bruijn, E., Shale, C., Duyvesteyn, K., Haidari, S., van Hoeck, A., Onstenk, W., et al. (2019) · Nature

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 1,106

Long‐term expanding human airway organoids for disease modeling

Sachs, N., Papaspyropoulos, A., Zomer‐van Ommen, D. D., Heo, I., Böttinger, L., Klay, D., Weeber, F., Huelsz‐Prince, G., Iakobachvili, N., Amatngalim, G. D., et al. (2019) · The EMBO Journal

Cystic Fibrosis Research AdvancesNeonatal Respiratory Health Research

Cited by 1,082

Sequential cancer mutations in cultured human intestinal stem cells

Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature

Cancer Cells and MetastasisGenetic factors in colorectal cancer

Cited by 1,067

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer

Cited by 935

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

Ooft, S. N., Weeber, F., Dijkstra, K. K., McLean, C. M., Kaing, S., van Werkhoven, E., Schipper, L., Hoes, L., Vis, D. J., van de Haar, J., et al. (2019) · Science Translational Medicine

Colorectal Cancer Treatments and StudiesCancer Cells and Metastasis

Cited by 813

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Blokzijl, F., Janssen, R., van Boxtel, R., & Cuppen, E. (2018) · Genome Medicine

Cancer Genomics and DiagnosticsGenomics and Phylogenetic Studies

Cited by 660

Pan-cancer landscape of homologous recombination deficiency.

Nguyen, L., W. M. Martens, J., Van Hoeck, A., & Cuppen, E. (2020) · Nature communications

BRCA gene mutations in cancerCancer Genomics and Diagnostics

Cited by 532

Diversity of microRNAs in human and chimpanzee brain

Berezikov, E., Thuemmler, F., van Laake, L. W., Kondova, I., Bontrop, R., Cuppen, E., & Plasterk, R. H. A. (2006) · Nature Genetics

MicroRNA in disease regulationChromosomal and Genetic Variations

Cited by 502

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

Weeber, F., van de Wetering, M., Hoogstraat, M., Dijkstra, K. K., Krijgsman, O., Kuilman, T., Gadellaa-van Hooijdonk, C. G. M., van der Velden, D. L., Peeper, D. S., Cuppen, E. P. J. G., et al. (2015) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 482

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., et al. (2017) · Science

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 461

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Redin, C., Brand, H., Collins, R. L., Kammin, T., Mitchell, E., Hodge, J. C., Hanscom, C., Pillalamarri, V., Seabra, C. M., Abbott, M.-A., et al. (2017) · Nature Genetics

Genomic variations and chromosomal abnormalitiesGenome Rearrangement Algorithms

Cited by 334

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte, C. J., Espejo Valle-Inclan, J., Hami, N., Lõhmussaar, K., Kopper, O., Vreuls, C. P. H., Jonges, G. N., van Diest, P., Nguyen, L., Clevers, H., et al. (2020) · Cell Reports

Ovarian cancer diagnosis and treatmentBRCA gene mutations in cancer

Cited by 303

Progress and prospects in rat genetics: a community view

Aitman, T. J., Critser, J. K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X. M., Flint, J., Gauguier, D., Geurts, A. M., Gould, M., Harris, P. C., et al. (2008) · Nature Genetics

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 291

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts

Schuijers, J., Junker, J. P., Mokry, M., Hatzis, P., Koo, B.-K., Sasselli, V., van der Flier, L. G., Cuppen, E., van Oudenaarden, A., & Clevers, H. (2015) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 273

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Dijkstra, K. K., Monkhorst, K., Schipper, L. J., Hartemink, K. J., Smit, E. F., Kaing, S., de Groot, R., Wolkers, M. C., Clevers, H., Cuppen, E., et al. (2020) · Cell Reports

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 254

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

Kruisselbrink, E., Guryev, V., Brouwer, K., Pontier, D. B., Cuppen, E., & Tijsterman, M. (2008) · Current Biology

DNA and Nucleic Acid ChemistryDNA Repair Mechanisms

Cited by 209

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

Kloosterman, W. P., Hoogstraat, M., Paling, O., Tavakoli-Yaraki, M., Renkens, I., Vermaat, J. S., van Roosmalen, M. J., van Lieshout, S., Nijman, I. J., Roessingh, W., et al. (2011) · Genome Biology

Cancer Genomics and DiagnosticsGenomic variations and chromosomal abnormalities

Cited by 204