Sternberg, Samuel H.

RNA-guided genetic silencing systems in bacteria and archaea

Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 1,851

Structures of Cas9 endonucleases reveal RNA-mediated conformational activation

Jinek, M., Jiang, F., Taylor, D. W., Sternberg, S. H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., et al. (2014) · Science

CRISPR and Genetic EngineeringEnzyme Structure and Function

Cited by 1,230

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

Chen, J. S., Dagdas, Y. S., Kleinstiver, B. P., Welch, M. M., Sousa, A. A., Harrington, L. B., Sternberg, S. H., Joung, J. K., Yildiz, A., & Doudna, J. A. (2017) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,168

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., et al. (2015) · Science

CRISPR and Genetic EngineeringBiomedical Ethics and Regulation

Cited by 733

Conformational control of DNA target cleavage by CRISPR–Cas9

Sternberg, S. H., LaFrance, B., Kaplan, M., & Doudna, J. A. (2015) · Nature

CRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry

Cited by 627

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Dagdas, Y. S., Chen, J. S., Sternberg, S. H., Doudna, J. A., & Yildiz, A. (2017) · Science Advances

CRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry

Cited by 293

Transposon-encoded nucleases use guide RNAs to promote their selfish spread

Meers, C., Le, H. C., Pesari, S. R., Hoffmann, F. T., Walker, M. W. G., Gezelle, J., Tang, S., & Sternberg, S. H. (2023) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 60

De novo gene synthesis by an antiviral reverse transcriptase

Tang, S., Conte, V., Zhang, D. J., Žedaveinytė, R., Lampe, G. D., Wiegand, T., Tang, L. C., Wang, M., Walker, M. W. G., George, J. T., et al. (2024) · Science

Bacteriophages and microbial interactionsBacterial Genetics and Biotechnology

Cited by 58

De novo gene synthesis by an antiviral reverse transcriptase

Tang, S., Conte, V., Zhang, D. J., Žedaveinytė, R., Lampe, G. D., Wiegand, T., Tang, L. C., Wang, M., Walker, M. W. G., George, J. T., et al. (2024) · Science

Bacteriophages and microbial interactionsBacterial Genetics and Biotechnology

Cited by 58

Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells

Lampe, G. D., Liang, A. R., Zhang, D. J., Fernández, I. S., & Sternberg, S. H. (2024) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 16

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons

Vaysset, H., Meers, C., Cury, J., Bernheim, A., & Sternberg, S. H. (2024) · Nature Microbiology

RNA modifications and cancerRNA and protein synthesis mechanisms

Cited by 9

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons

Vaysset, H., Meers, C., Cury, J., Bernheim, A., & Sternberg, S. H. (2025) · Nature Microbiology

RNA modifications and cancerRNA and protein synthesis mechanisms

Cited by 8