The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons
Open accessPreprint — published as 10.1038/s41564-024-01889-2 · Paper page
Abstract
Transposase genes are ubiquitous in all domains of life and provide a rich reservoir for the evolution of novel protein functions. Here we report deep evolutionary links between bacterial IS110 transposases, which catalyze RNA-guided DNA recombination using bridge RNAs, and archaeal/eukaryotic Nop5-family proteins, which promote RNA-guided RNA 2’-O-methylation using C/D-box snoRNAs. Based on conservation in the protein primary sequence, domain architecture, and three-dimensional structure, as well as common architectural features of the non-coding RNA components, we propose that programmable RNA modification emerged via exaptation of components derived from IS110-like transposons. Alongside recent studies highlighting the origins of CRISPR-Cas9 and Cas12 in IS605-family transposons, these findings underscore how recurrent domestication events of transposable elements gave rise to complex RNA-guided biological mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Flagged first, then by citations
Research works printed but not linked: 50
- 10.1093/molbev/msad232 · DOI
- 10.1021/acs.chemrev.7b00487 · DOI · Paper page
- 10.1261/rna.2396011 · DOI
- 10.1080/15476286.2016.1205768 · DOI
- 10.1126/science.abj6856 · DOI · Paper page
- 10.1038/s41586-021-04058-1 · DOI · Paper page
- 10.1038/s41586-023-06597-1 · DOI · Paper page
- 10.1261/rna.068312.118 · DOI
- 10.1016/S0092-8674(02)00718-3 · DOI
- 10.3390/biom8040106 · DOI
- 10.1146/annurev-biochem-091719-064225 · DOI
- 10.1126/science.1137924 · DOI
- 10.1261/rna.2690611 · DOI
- 10.1093/nar/22.11.2166 · DOI
- 10.1128/JB.185.16.4891-4900.2003 · DOI
- 10.1093/nar/gki408 · DOI
- 10.1126/science.aad6466 · DOI
- 10.1038/nature12581 · DOI
- 10.1101/2024.01.24.577089 · DOI
- 10.1101/2024.04.26.591405 · DOI
- 10.1261/rna.079379.122 · DOI
- 10.1073/pnas.0905128106 · DOI
- 10.1261/rna.2380410 · DOI
- 10.1128/microbiolspec.MDNA3-0046-2014 · DOI
- 10.1038/s41587-023-01773-0 · DOI · Paper page
- 10.1016/j.jmb.2017.12.007 · DOI · Paper page
- 10.1093/nar/gkt1414 · DOI
- 10.1093/nar/28.18.3417 · DOI
- 10.1093/gbe/evt173 · DOI
- 10.1128/jb.00783-15 · DOI
- 10.1093/nar/gku241 · DOI · Paper page
- 10.1093/nar/gky989 · DOI
- 10.1093/nar/gkab776 · DOI · Paper page
- 10.1093/nar/gkaa913 · DOI · Paper page
- 10.1093/nar/gkab1061 · DOI · Paper page
- 10.1093/nar/28.1.235 · DOI · Paper page
- 10.1038/s41592-022-01488-1 · DOI · Paper page
- 10.1101/2021.10.04.463034 · DOI · Paper page
- 10.1002/pro.4792 · DOI
- 10.1006/jmbi.1990.9999 · DOI · Paper page
- 10.1093/nar/gkf436 · DOI · Paper page
- 10.1371/journal.pcbi.1002195 · DOI · Paper page
- 10.1093/bioinformatics/btw006 · DOI
- 10.2390/biecoll-jib-2015-257 · DOI
- 10.1093/nar/gkad1044 · DOI
- 10.1093/nar/gkl217 · DOI
- 10.1371/journal.pbio.3001007 · DOI
- 10.1093/molbev/msu300 · DOI · Paper page
- 10.1093/molbev/msx281 · DOI · Paper page
- 10.1038/nmeth.4285 · DOI · Paper page
Metadata
- Authors
- Vaysset, H., Meers, C., Cury, J., Bernheim, A., & Sternberg, S. H.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Columbia University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bernheim, Aude
- Sternberg, Samuel H.
- Venue
- Nature Microbiology
- Publisher
- openRxiv
- Published
- 2024-06-21
- Volume
- 10
- Issue
- 1
- Pages
- 20-27
- ISSN
- 2058-5276 (ISSN-L)
- PMC
- PMC11930352
- OpenAlex
- W4405995742
- Cited by
- 9
- References
- 1
- Citations by year
- 2026: 3 · 2025: 6
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Nature Microbiology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by)
- PubMed Central (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation (2239685, CAREER)
- U.S. Department of Health and Human Services (GM143924)
- Institut Français de Bioinformatique (ANR-11-INBS-0013)
- Agence Nationale de la Recherche (ANR-11-INBS, ANR-11-INBS-0013)
- National Institutes of Health
- Irving Medical Center, Columbia University
- National Human Genome Research Institute (DP2HG011650, RM1HG009490)
- National Institute of General Medical Sciences (F32GM143924)
- HORIZON EUROPE European Research Council (101040529)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- box C/D snoRNA, exaptation, protein domain architecture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
