Bouwmeester, Tewis

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature

Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

Cited by 759

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M., & De Robertis, E. M. (1997) · Mechanisms of Development

Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

Cited by 460

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics

Hippo pathway signaling and YAP/TAZGenomics and Chromatin Dynamics

Cited by 414

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 359

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 216

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 166

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Bidinosti, M., Botta, P., Krüttner, S., Proenca, C. C., Stoehr, N., Bernhard, M., Fruh, I., Mueller, M., Bonenfant, D., Voshol, H., et al. (2016) · Science

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 151

A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction

Ting, P. Y., Borikar, S., Kerrigan, J. R., Thomsen, N. M., Aghania, E., Hinman, A. E., Reyes, A., Pizzato, N., Fodor, B. D., Wu, F., et al. (2024) · Science

Hemoglobinopathies and Related DisordersProtein Degradation and Inhibitors

Cited by 97

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.

Fernández‐Montalván, A., Bouwmeester, T., Joberty, G., Mader, R., Mahnke, M., Pierrat, B., Schlaeppi, J., Worpenberg, S., & Gerhartz, B. (2007) · The FEBS Journal

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 96

High-Throughput Screening Using iPSC-Derived Neuronal Progenitors to Identify Compounds Counteracting Epigenetic Gene Silencing in Fragile X Syndrome

Kaufmann, M., Schuffenhauer, A., Fruh, I., Klein, J., Thiemeyer, A., Rigo, P., Gomez-Mancilla, B., Heidinger-Millot, V., Bouwmeester, T., Schopfer, U., et al. (2015) · SLAS DISCOVERY

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 87

Structural basis of BRCC36 function in DNA repair and immune regulation

Rabl, J., Bunker, R. D., Schenk, A. D., Cavadini, S., Gill, M. E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M. S., Ibrahim, A. F. M., Branigan, E., et al. (2019) · Molecular Cell

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 84

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 84

Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation

Brauchle, M., Yao, Z., Arora, R., Thigale, S., Clay, I., Inverardi, B., Fletcher, J., Taslimi, P., Acker, M. G., Gerrits, B., et al. (2013) · PLoS ONE

Epigenetics and DNA MethylationCancer-related gene regulation

Cited by 79

Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease

Saponara, E., Penno, C., Orsini, V., Wang, Z.-Y., Fischer, A., Aebi, A., Matadamas-Guzman, M. L., Brun, V., Fischer, B., Brousseau, M., et al. (2023) · The American Journal of Pathology

Liver Disease Diagnosis and TreatmentWnt/β-catenin signaling in development and cancer

Cited by 22