Goodell, Margaret A.

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 1,122

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. (2010) · Nature

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 877

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., et al. (2014) · Nature

Muscle Physiology and DisordersPI3K/AKT/mTOR signaling in cancer

Cited by 776

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 686

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

Hsu, J. I., Dayaram, T., Tovy, A., De Braekeleer, E., Jeong, M., Wang, F., Zhang, J., Heffernan, T. P., Gera, S., Kovacs, J. J., et al. (2018) · Cell stem cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 425

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsHematopoietic Stem Cell Transplantation

Cited by 407

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells

Challen, G. A., Sun, D., Mayle, A., Jeong, M., Luo, M., Rodriguez, B., Mallaney, C., Celik, H., Yang, L., Xia, Z., et al. (2014) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 354

Stem cells and healthy aging

Goodell, M. A., & Rando, T. A. (2015) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 347

Large conserved domains of low DNA methylation maintained by Dnmt3a

Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G. A., Rodriguez, B., Zhang, X., Chavez, L., Wang, H., Hannah, R., et al. (2014) · Nature Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 324

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

Ergen, A. V., Boles, N. C., & Goodell, M. A. (2012) · Blood

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 280

Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Gundry, M. C., Brunetti, L., Lin, A., Mayle, A. E., Kitano, A., Wagner, D., Hsu, J. I., Hoegenauer, K. A., Rooney, C. M., Goodell, M. A., et al. (2016) · Cell Reports

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 265

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Zhang, X., Su, J., Jeong, M., Ko, M., Huang, Y., Park, H. J., Guzman, A., Lei, Y., Huang, Y.-H., Rao, A., et al. (2016) · Nature Genetics

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 258

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Jeong, M., Park, H. J., Celik, H., Ostrander, E. L., Reyes, J. M., Guzman, A., Rodriguez, B., Lei, Y., Lee, Y., Ding, L., et al. (2018) · Cell Reports

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 243

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

Mayle, A., Yang, L., Rodriguez, B., Zhou, T., Chang, E., Curry, C. V., Challen, G. A., Li, W., Wheeler, D., Rebel, V. I., et al. (2015) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 235

Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein

Lei, Y., Zhang, X., Su, J., Jeong, M., Gundry, M. C., Huang, Y.-H., Zhou, Y., Li, W., & Goodell, M. A. (2017) · Nature Communications

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 218

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

Kim, S. J., Zhao, H., Hardikar, S., Singh, A. K., Goodell, M. A., & Chen, T. (2013) · Blood

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 180

Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones

Challen, G., & Goodell, M. A. (2020) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 131

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

Luo, C., Lee, Q. Y., Wapinski, O., Castanon, R., Nery, J. R., Mall, M., Kareta, M. S., Cullen, S. M., Goodell, M. A., Chang, H. Y., et al. (2019) · eLife

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 76

Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners

Sandoval, J. E., Huang, Y.-H., Muise, A., Goodell, M. A., & Reich, N. O. (2019) · Journal of Biological Chemistry

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 66

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion

Tovy, A., Reyes, J. M., Gundry, M. C., Brunetti, L., Lee-Six, H., Petljak, M., Park, H. J., Guzman, A. G., Rosas, C., Jeffries, A. R., et al. (2020) · Cell Stem Cell

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 30

Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

Maneix, L., Iakova, P., Lee, C. G., Moree, S. E., Lu, X., Datar, G. K., Hill, C. T., Spooner, E., King, J. C. K., Sykes, D. B., et al. (2024) · Nature Cell Biology

Heat shock proteins researchSignaling Pathways in Disease

Cited by 28

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice

Matatall, K. A., Wathan, T. K., Nguyen, M., Chen, H., McDonald, A., Qi, G., Belk, J. A., Florez, M. A., Le, D. T., Olarinde, T., et al. (2025) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 23

Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors

Rossi, L., Lemoli, R. M., & Goodell, M. A. (2013) · Experimental Hematology

Adenosine and Purinergic SignalingHematopoietic Stem Cell Transplantation

Cited by 20

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice

Matatall, K. A., Wathan, T. K., Nguyen, M., Chen, H., McDonald, A., Qi, G., Belk, J. A., Florez, M. A., Le, D. T., Olarinde, T., et al. (2025) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 3