Iwakura, Yoichiro

Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

Yamagishi, R., Kamachi, F., Nakamura, M., Yamazaki, S., Kamiya, T., Takasugi, M., Cheng, Y., Nonaka, Y., Yukawa-Muto, Y., Thuy, L. T. T., et al. (2022) · Science Immunology

IL-33, ST2, and ILC PathwaysInflammasome and immune disorders

Cited by 173

IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ

Yoshida, T., Yasumura, M., Uemura, T., Lee, S.-J., Ra, M., Taguchi, R., Iwakura, Y., & Mishina, M. (2011) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 166

Interleukin-1 Receptor Accessory Protein Organizes Neuronal Synaptogenesis as a Cell Adhesion Molecule

Yoshida, T., Shiroshima, T., Lee, S.-J., Yasumura, M., Uemura, T., Chen, X., Iwakura, Y., & Mishina, M. (2012) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 134

TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

Fei, M., Bhatia, S., Oriss, T. B., Yarlagadda, M., Khare, A., Akira, S., Saijo, S., Iwakura, Y., Fallert Junecko, B. A., Reinhart, T. A., et al. (2011) · Proceedings of the National Academy of Sciences

Asthma and respiratory diseasesAntifungal resistance and susceptibility

Cited by 127

Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role

Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., & David, G. (2019) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 119

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis

Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., & Divanovic, S. (2016) · PLOS ONE

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 116

Arthritis flares mediated by tissue-resident memory T cells in the joint

Chang, M. H., Levescot, A., Nelson-Maney, N., Blaustein, R. B., Winden, K. D., Morris, A., Wactor, A., Balu, S., Grieshaber-Bouyer, R., Wei, K., et al. (2021) · Cell Reports

Rheumatoid Arthritis Research and TherapiesT-cell and B-cell Immunology

Cited by 115

Identification of the Cellular Sensor That Stimulates the Inflammatory Response to Sterile Cell Death

Kono, H., Karmarkar, D., Iwakura, Y., & Rock, K. L. (2010) · The Journal of Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 101

Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells

Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., et al. (2011) · Journal of Experimental Medicine

Rheumatoid Arthritis Research and TherapiesT-cell and B-cell Immunology

Cited by 100

Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity

Zhang, C., Feng, J., Du, J., Zhuo, Z., Yang, S., Zhang, W., Wang, W., Zhang, S., Iwakura, Y., Meng, G., et al. (2018) · Cellular & Molecular Immunology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 99

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons

Yokoyama, K., Tezuka, T., Kotani, M., Nakazawa, T., Hoshina, N., Shimoda, Y., Kakuta, S., Sudo, K., Watanabe, K., Iwakura, Y., et al. (2011) · The EMBO Journal

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 75

Neutrophils Are Essential As A Source Of Il-17 In The Effector Phase Of Arthritis

Katayama, M., Ohmura, K., Yukawa, N., Terao, C., Hashimoto, M., Yoshifuji, H., Kawabata, D., Fujii, T., Iwakura, Y., & Mimori, T. (2013) · PLoS ONE

Rheumatoid Arthritis Research and TherapiesPsoriasis: Treatment and Pathogenesis

Cited by 66

IL-1 Receptor-Antagonist (IL-1Ra) Knockout Mice Show Anxiety-like Behavior by Aging

Wakabayashi, C., Numakawa, T., Odaka, H., Ooshima, Y., Kiyama, Y., Manabe, T., Kunugi, H., & Iwakura, Y. (2015) · Neuroscience Letters

Stress Responses and CortisolTryptophan and brain disorders

Cited by 14

Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa

Horino, T., Matsumoto, T., Uramatsu, M., Tanabe, M., Tateda, K., Miyazaki, S., Nakane, A., Iwakura, Y., & Yamaguchi, K. (2005) · Cytokine

Sepsis Diagnosis and TreatmentImmune Response and Inflammation

Cited by 13