Knolle, Percy A.

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister, D., Núñez, N. G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., et al. (2021) · Nature

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

Cited by 1,294

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

Limmer, A., Ohl, J., Kurts, C., Ljunggren, H.-G., Reiss, Y., Groettrup, M., Momburg, F., Arnold, B., & Knolle, P. A. (2000) · Nature Medicine

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 758

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 678

NLRP3 inflammasome activity is negatively controlled by miR-223

Bauernfeind, F., Rieger, A., Schildberg, F. A., Knolle, P. A., Schmid-Burgk, J. L., & Hornung, V. (2012) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 544

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 518

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

Induction of cytokine production in naive CD4+ T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells☆, ☆☆

KNOLLE, P., SCHMITT, E., JIN, S., GERMANN, T., DUCHMANN, R., HEGENBARTH, S., GERKEN, G., & LOHSE, A. (1999) · Gastroenterology

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 298

Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance

Diehl, L., Schurich, A., Grochtmann, R., Hegenbarth, S., Chen, L., & Knolle, P. A. (2008) · Hepatology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 291

Toll–Like Receptor 2–Mediated Innate Immune Response in Human Nonparenchymal Liver Cells Toward Adeno–Associated Viral Vectors

Hösel, M., Broxtermann, M., Janicki, H., Esser, K., Arzberger, S., Hartmann, P., Gillen, S., Kleeff, J., Stabenow, D., Odenthal, M., et al. (2012) · Hepatology

Virus-based gene therapy researchImmune Response and Inflammation

Cited by 219

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

Huang, L.-R., Wohlleber, D., Reisinger, F., Jenne, C. N., Cheng, R.-L., Abdullah, Z., Schildberg, F. A., Odenthal, M., Dienes, H.-P., van Rooijen, N., et al. (2013) · Nature Immunology

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 216

Cross‐presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance

Limmer, A., Ohl, J., Wingender, G., Berg, M., Jüngerkes, F., Schumak, B., Djandji, D., Scholz, K., Klevenz, A., Hegenbarth, S., et al. (2005) · European Journal of Immunology

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 169

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances

Bauernfeind, F., Niepmann, S., Knolle, P. A., & Hornung, V. (2016) · The Journal of Immunology

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 137

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

Schurich, A., Berg, M., Stabenow, D., Böttcher, J., Kern, M., Schild, H.-J., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., et al. (2010) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 124

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 108

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Bosch, M., Kallin, N., Donakonda, S., Zhang, J. D., Wintersteller, H., Hegenbarth, S., Heim, K., Ramirez, C., Fürst, A., Lattouf, E. I., et al. (2024) · Nature

Hepatitis B Virus StudiesT-cell and B-cell Immunology

Cited by 97

Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Schildberg, F. A., Wojtalla, A., Siegmund, S. V., Endl, E., Diehl, L., Abdullah, Z., Kurts, C., & Knolle, P. A. (2011) · Hepatology

Liver physiology and pathologyT-cell and B-cell Immunology

Cited by 90

Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates

Franken, L., Klein, M., Spasova, M., Elsukova, A., Wiedwald, U., Welz, M., Knolle, P., Farle, M., Limmer, A., & Kurts, C. (2015) · Scientific Reports

Characterization and Applications of Magnetic NanoparticlesImmune cells in cancer

Cited by 54

Staying local-antigen presentation in the liver

Knolle, P. A. (2016) · Current Opinion in Immunology

Immunotherapy and Immune ResponsesLiver physiology and pathology

Cited by 42

Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance

Schölzel, K., Schildberg, F. A., Welz, M., Börner, C., Geiger, S., Kurts, C., Heikenwälder, M., Knolle, P. A., & Wohlleber, D. (2014) · Journal of Hepatology

Immunotherapy and Immune ResponsesLiver physiology and pathology

Cited by 31

Auto-Aggressive CXCR6(+) CD8 T Cells Cause Liver Immune Pathology in NASH

Dudek, M., Knolle, P., Pfister, D., Heikenwälder, M., Donakonda, S., Laschinger, M., Hartmann, D., Hüser, N., Sebode, M., Filpe, P., et al. (2022) · Zeitschrift für Gastroenterologie

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 18

Tissue Determinants of Antiviral Immunity in the Liver

Wohlleber, D., & Knolle, P. A. (2025) · Zeitschrift für Gastroenterologie

Hepatitis B Virus StudiesLiver physiology and pathology

Cited by 3