NLRP3 inflammasome activity is negatively controlled by miR-223
Abstract
Inflammasomes are multiprotein signaling platforms that form upon sensing microbe- or damage-associated molecular patterns. Upon their formation, caspase-1 is activated, leading to the processing of certain proinflammatory cytokines and the initiation of a special type of cell death, known as pyroptosis. Among known inflammasomes, NLRP3 takes on special importance because it appears to be a general sensor of cell stress. Moreover, unlike other inflammasome sensors, NLRP3 inflammasome activity is under additional transcriptional regulation. In this study, we identify the myeloid-specific microRNA miR-223 as another critical regulator of NLRP3 inflammasome activity. miR-223 suppresses NLRP3 expression through a conserved binding site within the 3′ untranslated region of NLRP3, translating to reduced NLRP3 inflammasome activity. Although miR-223 itself is not regulated by proinflammatory signals, its expression varies among different myeloid cell types. Therefore, given the tight transcriptional control of NLRP3 message itself, miR-223 functions as an important rheostat controlling NLRP3 inflammasome activity.
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miR-223-3p represses NLRP3 and limits inflammasome activation in myeloid and microglial models.
“Additionally, miR-223-3p has been shown to repress NLRP3 and limit inflammasome activation in myeloid and microglial models (Bauernfeind et al., 2012; Long et al., 2020).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Bauernfeind et al., 2012
Cites
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- Authors
- Bauernfeind, F., Rieger, A., Schildberg, F. A., Knolle, P. A., Schmid-Burgk, J. L., & Hornung, V.
- Affiliations
- Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn , 53127 Bonn,
- Institutes of Molecular Medicine and Experimental Immunology, University Hospital, University of Bonn , 53127 Bonn,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10
- Volume
- 189
- Issue
- 8
- Pages
- 4175-4181
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 463
- References
- 9
- Language
- en
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