Schaper, Fred

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 3,272

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 2,130

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 388

Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

Bode, J. G., Albrecht, U., Häussinger, D., Heinrich, P. C., & Schaper, F. (2012) · European Journal of Cell Biology

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 379

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Niemand, C., Nimmesgern, A., Haan, S., Fischer, P., Schaper, F., Rossaint, R., Heinrich, P. C., & Müller-Newen, G. (2003) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 357

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130

Lehmann, U., Schmitz, J., Weissenbach, M., Sobota, R. M., Hörtner, M., Friederichs, K., Behrmann, I., Tsiaris, W., Sasaki, A., Schneider-Mergener, J., et al. (2003) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 236

LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

Bode, J. G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., Häussinger, D., Heinrich, P. C., & Graeve, L. (1999) · FEBS Letters

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 196

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling

Reeh, H., Rudolph, N., Billing, U., Christen, H., Streif, S., Bullinger, E., Schliemann-Bullinger, M., Findeisen, R., Schaper, F., Huber, H. J., et al. (2019) · Cell Communication and Signaling

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 180

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

SCHAPER, F., GENDO, C., ECK, M., SCHMITZ, J., GRIMM, C., ANHUF, D., KERR, I. M., & HEINRICH, P. C. (1998) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 178

Interleukin-6 signalling: More than Jaks and STATs

Eulenfeld, R., Dittrich, A., Khouri, C., Müller, P. J., Mütze, B., Wolf, A., & Schaper, F. (2012) · European Journal of Cell Biology

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 171

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

Sharf, R., Meraro, D., Azriel, A., Thornton, A. M., Ozato, K., Petricoin, E. F., Larner, A. C., Schaper, F., Hauser, H., & Levi, B.-Z. (1997) · Journal of Biological Chemistry

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 162

Expression of suppressors of cytokine signaling during liver regeneration

Campbell, J. S., Prichard, L., Schaper, F., Schmitz, J., Stephenson-Famy, A., Rosenfeld, M. E., Argast, G. M., Heinrich, P. C., & Fausto, N. (2001) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 156

Different protein turnover of interleukin‐6‐type cytokine signalling components

Siewert, E., Müller‐Esterl, W., Starr, R., Heinrich, P. C., & Schaper, F. (1999) · European Journal of Biochemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 121

The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction

Schmitz, J., Dahmen, H., Grimm, C., Gendo, C., Müller-Newen, G., Heinrich, P. C., & Schaper, F. (2000) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 92

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

FISCHER, P., LEHMANN, U., SOBOTA, R. M., SCHMITZ, J., NIEMAND, C., LINNEMANN, S., HAAN, S., BEHRMANN, I., YOSHIMURA, A., JOHNSTON, J. A., et al. (2004) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 72

Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling

Billing, U., Jetka, T., Nortmann, L., Wundrack, N., Komorowski, M., Waldherr, S., Schaper, F., & Dittrich, A. (2019) · Communications Biology

Cytokine Signaling Pathways and InteractionsGene Regulatory Network Analysis

Cited by 64

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane

Eulenfeld, R., & Schaper, F. (2009) · Journal of Cell Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 57

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

Fiebelkow, J., Guendel, A., Guendel, B., Mehwald, N., Jetka, T., Komorowski, M., Waldherr, S., Schaper, F., & Dittrich, A. (2021) · Cell Communication and Signaling

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 53

Glucocorticoids Increase Interleukin–6–Dependent Gene Induction by Interfering With the Expression of the Suppressor of Cytokine Signaling 3 Feedback Inhibitor

Dittrich, A., Khouri, C., Sackett, S. D., Ehlting, C., Böhmer, O., Albrecht, U., Bode, J. G., Trautwein, C., & Schaper, F. (2012) · Hepatology

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 51

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability

Williams, J. J. L., Alotaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G. S., Schaper, F., Pilch, P. F., & Palmer, T. M. (2018) · Nature Communications

Cytokine Signaling Pathways and InteractionsCaveolin-1 and cellular processes

Cited by 35

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling

Dittrich, A., Quaiser, T., Khouri, C., Görtz, D., Mönnigmann, M., & Schaper, F. (2012) · Molecular BioSystems

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

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