Thyfault, John P.

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017) · Physiological Reviews

Physical Activity and HealthGenetics and Physical Performance

Cited by 696

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

Rector, R. S., Thyfault, J. P., Uptergrove, G. M., Morris, E. M., Naples, S. P., Borengasser, S. J., Mikus, C. R., Laye, M. J., Laughlin, M. H., Booth, F. W., et al. (2010) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentMitochondrial Function and Pathology

Cited by 488

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

Hulver, M. W., Berggren, J. R., Carper, M. J., Miyazaki, M., Ntambi, J. M., Hoffman, E. P., Thyfault, J. P., Stevens, R., Dohm, G. L., Houmard, J. A., et al. (2005) · Cell Metabolism

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 384

Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats

Rector, R. S., Thyfault, J. P., Morris, R. T., Laye, M. J., Borengasser, S. J., Booth, F. W., & Ibdah, J. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 321

A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity

Krogh-Madsen, R., Thyfault, J. P., Broholm, C., Mortensen, O. H., Olsen, R. H., Mounier, R., Plomgaard, P., van Hall, G., Booth, F. W., & Pedersen, B. K. (2010) · Journal of Applied Physiology

Physical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 311

Impaired plasma fatty acid oxidation in extremely obese women

Thyfault, J. P., Kraus, R. M., Hickner, R. C., Howell, A. W., Wolfe, R. R., & Dohm, G. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Bariatric Surgery and OutcomesAdipose Tissue and Metabolism

Cited by 122

Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long‐Evans Tokushima Fatty (OLETF) rats

Rector, R. S., Thyfault, J. P., Laye, M. J., Morris, R. T., Borengasser, S. J., Uptergrove, G. M., Chakravarthy, M. V., Booth, F. W., & Ibdah, J. A. (2008) · The Journal of Physiology

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 110

Modification of Insulin Sensitivity and Glycemic Control by Activity and Exercise

ROBERTS, C. K., LITTLE, J. P., & THYFAULT, J. P. (2013) · Medicine & Science in Sports & Exercise

Physical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 95

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

Thyfault, J. P., Cree, M. G., Zheng, D., Zwetsloot, J. J., Tapscott, E. B., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Muoio, D. M., & Dohm, G. L. (2007) · American Journal of Physiology-Cell Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 87

Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue

Laye, M. J., Rector, R. S., Borengasser, S. J., Naples, S. P., Uptergrove, G. M., Ibdah, J. A., Booth, F. W., & Thyfault, J. P. (2009) · Journal of Applied Physiology

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 77

Inactivity induces increases in abdominal fat

Laye, M. J., Thyfault, J. P., Stump, C. S., & Booth, F. W. (2007) · Journal of Applied Physiology

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 76

Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat

Morris, R. T., Laye, M. J., Lees, S. J., Rector, R. S., Thyfault, J. P., & Booth, F. W. (2008) · Journal of Applied Physiology

Exercise and Physiological ResponsesAdipose Tissue and Metabolism

Cited by 56

Setting the stage: possible mechanisms by which acute contraction restores insulin sensitivity in muscle

Thyfault, J. P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 53

Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats

Rector, R. S., Uptergrove, G. M., Borengasser, S. J., Mikus, C. R., Morris, E. M., Naples, S. P., Laye, M. J., Laughlin, M. H., Booth, F. W., Ibdah, J. A., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 48

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Erickson, M. L., Allen, J. M., Beavers, D. P., Collins, L. M., Davidson, K. W., Erickson, K. I., Esser, K. A., Hesselink, M. K. C., Moreau, K. L., Laber, E. B., et al. (2023) · GeroScience

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 47

Functional adaptations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat

Martin, J. S., Padilla, J., Jenkins, N. T., Crissey, J. M., Bender, S. B., Rector, R. S., Thyfault, J. P., & Laughlin, M. H. (2012) · Journal of Applied Physiology

Cardiovascular and exercise physiologyNitric Oxide and Endothelin Effects

Cited by 30

Exercise drives metabolic integration between muscle, adipose and liver metabolism and protects against aging-related diseases

Cao, X., & Thyfault, J. P. (2023) · Experimental Gerontology

Adipose Tissue and MetabolismPhysical Activity and Health

Cited by 25

Wheel running prevents the accumulation of monounsaturated fatty acids in the liver of ovariectomized mice by attenuating changes in SCD-1 content

Jackson, K. C., Wohlers, L. M., Valencia, A. P., Cilenti, M., Borengasser, S. J., Thyfault, J. P., & Spangenburg, E. E. (2011) · Applied Physiology, Nutrition, and Metabolism

Lipid metabolism and biosynthesisDiet, Metabolism, and Disease

Cited by 21

Metabolic profiling of muscle contraction in lean compared with obese rodents

Thyfault, J. P., Cree, M. G., Tapscott, E. B., Bell, J. A., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Dohm, G. L., & Muoio, D. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 21

APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology

Lysaker, C. R., Johnson, C. N., Csikos, V., Franczak, E., Benson, M., Gilmore, C. A., Birky, C. J., Davis, X., McCoin, C. S., Smith, K. P., et al. (2026) · npj Dementia

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 1