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Cited by 76Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Inactivity induces increases in abdominal fat

Laye, Matthew J., Thyfault, John P., Stump, Craig S., Booth, Frank W.·2007·Journal of Applied Physiology
DOI 10.1152/japplphysiol.01018.2006
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Abstract

Previously, inducing inactivity for 53 h after 21 days of voluntary running resulted in a 25 and 48% increase in epididymal and omental fat pad weights, respectively, while rats continued to eat more than a group that never had access to a running wheel (J Physiol 565: 911-925, 2005). We wanted to test the hypothesis that inactivity, independent of excessive caloric intake, could induce an increase in fat pad mass. Twenty-one-day-old rats were given access to voluntary running wheels for 42-43 days so that they were running approximately 9 km/day in the last week of running, after which wheels were locked for 5, 53, or 173 h (WL5, WL53, WL173) before the rats were killed. During the 53 and 173 h of inactivity, one group of animals was pair fed (PF) to match sedentary controls, whereas the other continued to eat ad libitum (AL). Epididymal and retroperitoneal fat masses were significantly increased in the WL173-PF vs. the WL5 group, whereas epididymal, perirenal, and retroperitoneal fat masses were all significantly increased in the WL173-AL group compared with the WL5 group. Additionally, hyperplasia, and not hypertrophy, of the epididymal fat mass was responsible for the increase at WL173-AL as demonstrated by a significant increase in cell number vs. WL5, with no change in cell diameter or volume. Thus two important findings have been elucidated: 1) increases in measured abdominal fat masses occur in both AL and PF groups at WL173, and 2) adipocyte expansion via hyperplasia occurred with an ad libitum diet following cessation of voluntary running.

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  • An association has been established between physical inactivity and visceral fat in both rodents and humans.

    “In fact, an association has been established between physical inactivity and visceral fat in both rodents (217) and humans (133, 218-220).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [217]

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Authors
Laye, M. J., Thyfault, J. P., Stump, C. S., & Booth, F. W.
Affiliations
University of Missouri (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2007-04
Volume
102
Issue
4
Pages
1341-1347
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.01018.2006
OpenAlex
W2092137954
Cited by
76
References
32
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2020: 3 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 7
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Missouri
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
physical inactivity, abdominal fat, epididymal adipose tissue, omental fat, retroperitoneal fat, adipocyte hyperplasia, adipocyte hypertrophy, voluntary running, pair feeding, ad libitum feeding, energy balance
MeSH terms
Abdomen, Adaptation, Physiological, Adipose Tissue, Animals, Hyperplasia, Male, Motor Activity, Rats, Inbred BN, Rats, Inbred F344, Adiposity, Rats

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