Pang, K. Sandy

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 797

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 217

Organ Clearance Concepts: New Perspectives on Old Principles

Sirianni, G. L., & Pang, K. S. (1997) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 89

Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparation

Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 77

Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts

Pang, K. S., Weiss, M., & Macheras, P. (2007) · The AAPS Journal

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 61