Giorgio, Marco

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature

Genetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulation

Cited by 1,712

Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors

Butelli, E., Titta, L., Giorgio, M., Mock, H.-P., Matros, A., Peterek, S., Schijlen, E. G. W. M., Hall, R. D., Bovy, A. G., Luo, J., et al. (2008) · Nature Biotechnology

Plant Gene Expression AnalysisPlant biochemistry and biosynthesis

Cited by 1,238

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis

Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., et al. (2005) · Cell

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,176

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 436

Deletion of the p66 Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet

Napoli, C., Martin-Padura, I., de Nigris, F., Giorgio, M., Mansueto, G., Somma, P., Condorelli, M., Sica, G., De Rosa, G., & Pelicci, P. (2003) · Proceedings of the National Academy of Sciences

Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

Cited by 380

Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

Rota, M., LeCapitaine, N., Hosoda, T., Boni, A., De Angelis, A., Padin-Iruegas, M. E., Esposito, G., Vitale, S., Urbanek, K., Casarsa, C., et al. (2006) · Circulation Research

Congenital heart defects researchTelomeres, Telomerase, and Senescence

Cited by 330

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

Berniakovich, I., Trinei, M., Stendardo, M., Migliaccio, E., Minucci, S., Bernardi, P., Pelicci, P. G., & Giorgio, M. (2008) · Journal of Biological Chemistry

Adipose Tissue and MetabolismRedox biology and oxidative stress

Cited by 161

Blood orange juice inhibits fat accumulation in mice

Titta, L., Trinei, M., Stendardo, M., Berniakovich, I., Petroni, K., Tonelli, C., Riso, P., Porrini, M., Minucci, S., Pelicci, P. G., et al. (2010) · International Journal of Obesity

Phytochemicals and Antioxidant ActivitiesDiet, Metabolism, and Disease

Cited by 145

Apoptosis and Aging: Role of p66 Shc Redox Protein

Migliaccio, E., Giorgio, M., & Pelicci, P. G. (2006) · Antioxidants & Redox Signaling

Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

Cited by 123

Low Oxygen Tension Maintains Multipotency, Whereas Normoxia Increases Differentiation of Mouse Bone Marrow Stromal Cells

Berniakovich, I., & Giorgio, M. (2013) · International Journal of Molecular Sciences

Mesenchymal stem cell researchHematopoietic Stem Cell Transplantation

Cited by 103

Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice

Berry, A., Capone, F., Giorgio, M., Pelicci, P. G., de Kloet, E. R., Alleva, E., Minghetti, L., & Cirulli, F. (2007) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 81

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation

Menini, S., Iacobini, C., Ricci, C., Oddi, G., Pesce, C., Pugliese, F., Block, K., Abboud, H. E., Giorgio, M., Migliaccio, E., et al. (2007) · Diabetologia

Advanced Glycation End Products researchChronic Kidney Disease and Diabetes

Cited by 64

The Shc locus regulates insulin signaling and adiposity in mammals

Tomilov, A. A., Ramsey, J. J., Hagopian, K., Giorgio, M., Kim, K. M., Lam, A., Migliaccio, E., Lloyd, K. C., Berniakovich, I., Prolla, T. A., et al. (2011) · Aging Cell

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 64

Cyanidin-3-O-β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in mice

Talagavadi, V., Rapisarda, P., Galvano, F., Pelicci, P., & Giorgio, M. (2016) · Journal of Functional Foods

Natural Antidiabetic Agents StudiesMetabolism, Diabetes, and Cancer

Cited by 57

p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice

Martin-Padura, I., de Nigris, F., Migliaccio, E., Mansueto, G., Minardi, S., Rienzo, M., Lerman, L. O., Stendardo, M., Giorgio, M., De Rosa, G., et al. (2008) · Endothelium

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 52

The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration

Savino, C., Pelicci, P., & Giorgio, M. (2013) · Oxidative Medicine and Cellular Longevity

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 46

The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation

Frijhoff, J., Dagnell, M., Augsten, M., Beltrami, E., Giorgio, M., & Östman, A. (2014) · Free Radical Biology and Medicine

Protein Tyrosine PhosphatasesRedox biology and oxidative stress

Cited by 43

Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri

Priami, C., De Michele, G., Cotelli, F., Cellerino, A., Giorgio, M., Pelicci, P. G., & Migliaccio, E. (2015) · Aging and Disease

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 16

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan

Giorgio, M., Stendardo, M., Migliaccio, E., & Pelicci, P. G. (2016) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 11