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Greater resistance to inflammation at adulthood could contribute to extended life span of p66Shc−/− mice

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Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

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Small molecule compounds alleviate anisomycin-induced oxidative stress injury in SH-SY5Y cells via downregulation of p66shc and Aβ1–42 expression

Wang, Y., LIU, T., Pan, W., Chi, H., Chen, J., Yu, Z., & Chen, C. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2921 · Cited by 17 · see citing works

Carnosic acid attenuates neuropathic pain in rat through the activation of spinal sirtuin1 and down-regulation of p66shc expression

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Epigenetic enhancement of p66Shc during cellular replicative or premature senescence

Zhang, W., Ji, W., Yang, L., Xu, Y., Yang, J., & Zhuang, Z. (2010) · Toxicology · doi:10.1016/j.tox.2010.07.011 · Cited by 16 · see citing works

Western diet-induced cognitive and metabolic dysfunctions in aged mice are prevented by rosmarinic acid in a sex-dependent fashion

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P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan

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Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion

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The influential responsibility of sirtuins in senescence and associated diseases: A review

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Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers

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Selective targeting of chronic social stress-induced activated neurons identifies neurogenesis-related genes to be associated with resilience in female mice

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A multi‐ingredient dietary supplement abolishes large‐scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice

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Genetic diversity contributes to abnormalities in pain behaviors between young and old rats

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Urinary Biopyrrins: Potential Biomarker for Monitoring of the Response to Treatment with Anxiolytics

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Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?

Negah, S. S., & Forouzanfar, F. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230904150907 · Cited by 7 · see citing works

Ethnopharmacological approaches in mood and anxiety disorders. The relevance of the oxidative stress status

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Shortened Daily Photoperiod Alleviates Anxiety-like Behaviour by Antioxidant Effect and Changes Serum Fatty Acid Profile in Diabetic Rats

Vasović, D. D., Vesković, M. N., Šutulović, N., Hrnčić, D., Takić, M. M., Jerotić, D., Matic, M. G., Stanojlović, O. P., Ivković, S., Macura, I. J., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13050744 · Cited by 5 · see citing works

Long-Term Changes in Pain Sensitivity in an Animal Model of Social Anxiety

Berry, A., Bellisario, V., Capoccia, S., Francia, N., Alleva, E., & Cirulli, F. (2014) · Veterinary Sciences · doi:10.3390/vetsci1020077 · Cited by 5 · see citing works

Conjunctivally administered NGF antibody reduces pain sensitivity and anxiety-like behavioral responses in aged female mice

Berry, A., Aloe, L., Rossi, S., Bonsignore, L. T., Capone, F. T., Alleva, E., & Cirulli, F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.037 · Cited by 5 · see citing works

Increased Serum Cu/Zn Superoxide Dismutase in Individuals with Anxiety

Russo, A. J. (2010) · Proteomics Insights · doi:10.4137/pri.s5180 · Cited by 5 · see citing works

Recombinant adenovirus of human p66Shc inhibits MCF-7 cell proliferation

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Apocynin, a Selective NADPH Oxidase (Nox2) Inhibitor, Ameliorates Behavioural and Learning Deficits in the Fragile X Syndrome Mouse Model

de Diego‐Otero, Y., Bekay, R. E., García-Guirado, F., Salido, L. S., & Giráldez‐Pérez, R. M. (2024) · Biomedicines · doi:10.3390/biomedicines12122887 · Cited by 4 · see citing works

High-Fat Diet and Foetal Programming: Use of P66Shc Knockouts and Implications for Human Kind

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Oxidative Stress in Depression and Other Comorbid Disorders

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Investigation the protective effect of vitamin C on anxiety and oxidative stress modulation in male rats treated with progesterone

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Effects of valproic acid on transcript levels in neurotrophin signaling pathway in mice hippocampus according to the implementation period

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Chemical Biology of Oxidative Stress and Its Role in the Pathophysiology of Neuropsychiatric Disorders

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Original Contribution INVESTIGATION THE PROTECTIVE EFFECT OF VITAMIN C ON ANXIETY AND OXIDATIVE STRESS MODULATION IN MALE RATS TREATED WITH PROGESTERONE

Ferdowsi, K., Hatami, H., & Dehghan, G. (2016)

NEW RESEARCH HORIZON Permanent embryo arrest: molecular and cellular concepts

Betts, D. H., & Madan, P. (2008)

UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL DEPARTAMENTO DE BIOQUÍMICA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS - BIOQUÍMICA CONSUMO DE DIETA HIPERPALATÁVEL, ALTERAÇÕES METABÓLICAS E COMPORTAMENTAIS: UM MODELO DE OBESIDADE EM RATOS E SUAS CONSEQUÊNCIAS

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High Intensity Focused Ultrasound: A Novel Model of Mild Traumatic Brain Injury

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Developmental ORIgins of Healthy and Unhealthy AgeiNg

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The activation of p66shc in the prelimbic cortex contributes to the development of neuropathic pain

Wang, R., He, T., Li, C., Du, R., Lin, Q., & Wang, Y. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111808

Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice

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Deletion of the lifespan determinant p66Shc improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice

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Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity

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Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors

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p66Shc: at the crossroad of oxidative stress and the genetics of aging

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The p66Shc gene paves the way for healthspan: Evolutionary and mechanistic perspectives

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