Immunoreactive interleukin-1β localization in the rat forebrain

Lechan, Ronald M.; Toni, R.; Clark, B.D.; Cannon, J.G.; Shaw, A.R.; Dinarello, C.A.; Reichlin, S.

doi:10.1016/0006-8993(90)90445-h

Cited by 340Neuroinflammation and Neurodegeneration MechanismsNeuropeptides and Animal PhysiologyTryptophan and brain disorders

Immunoreactive interleukin-1β localization in the rat forebrain

Lechan, Ronald M., Toni, R., Clark, B.D., Cannon, J.G., Shaw, A.R., Dinarello, C.A., Reichlin, S.·1990·Brain Research

DOI 10.1016/0006-8993(90)90445-h

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Abstract

To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

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High abundance of IL-1β has been described in steady-state in the hippocampus and hypothalamus of rats.
“Especially in the hippocampus and hypothalamus, high abundance of IL-1β has been described in steady-state in rats already in 1990, in regions of the brain conducting essential and conserved brain functions as memory and learning processes (202).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [202]

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Authors: Lechan, R. M., Toni, R., Clark, B. D., Cannon, J. G., Shaw, A. R., Dinarello, C. A., & Reichlin, S.
Affiliations: Tufts Medical Center (US)
Corresponding author: Lechan, Ronald M.
ORCID: Lechan, Ronald M.
Toni, R.
Shaw, A.R.
Dinarello, C.A.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1990-04
Volume: 514
Issue: 1
Pages: 135-140
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(90)90445-h
OpenAlex: W2051536500
Cited by: 340
References: 37
Citations by year: 2025: 5 · 2024: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 3 · 2014: 5 · 2013: 4 · 2012: 3
FWCI: 18.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 37021)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: IL-1β, brain cytokines, forebrain, hypothalamus, hippocampus, mossy fibers, olfactory tubercle, periventricular region, limbic system, autonomic regulation, neuroendocrine regulation, rats
MeSH terms: Animals, Frontal Lobe, Immunohistochemistry, Interleukin-1, Rabbits

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Immunoreactive interleukin-1β localization in the rat forebrain

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