Denu, John M.

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

Someya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M., & Prolla, T. A. (2010) · Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,150

Mechanism of Human SIRT1 Activation by Resveratrol

Borra, M. T., Smith, B. C., & Denu, J. M. (2005) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 1,065

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

Hallows, W. C., Lee, S., & Denu, J. M. (2006) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineCancer, Lipids, and Metabolism

Cited by 792

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

Feldman, J. L., Baeza, J., & Denu, J. M. (2013) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 637

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

Hebert, A. S., Dittenhafer-Reed, K. E., Yu, W., Bailey, D. J., Selen, E. S., Boersma, M. D., Carson, J. J., Tonelli, M., Balloon, A. J., Higbee, A. J., et al. (2013) · Molecular Cell

Sirtuins and Resveratrol in MedicineAdvanced Proteomics Techniques and Applications

Cited by 636

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

Krautkramer, K. A., Kreznar, J. H., Romano, K. A., Vivas, E. I., Barrett-Wilt, G. A., Rabaglia, M. E., Keller, M. P., Attie, A. D., Rey, F. E., & Denu, J. M. (2016) · Molecular Cell

Gut microbiota and healthEpigenetics and DNA Methylation

Cited by 607

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

Shimazu, T., Hirschey, M. D., Hua, L., Dittenhafer-Reed, K. E., Schwer, B., Lombard, D. B., Li, Y., Bunkenborg, J., Alt, F. W., Denu, J. M., et al. (2010) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 484

Chemical mechanisms of histone lysine and arginine modifications

Smith, B. C., & Denu, J. M. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Genomics and Chromatin DynamicsCancer-related gene regulation

Cited by 390

Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction

Hallows, W. C., Yu, W., Smith, B. C., Devires, M. K., Ellinger, J. J., Someya, S., Shortreed, M. R., Prolla, T., Markley, J. L., Smith, L. M., et al. (2011) · Molecular Cell

Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

Cited by 389

The Sir2 family of protein deacetylases

Denu, J. M. (2005) · Current Opinion in Chemical Biology

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 325

Sirtuin catalysis and regulation

Feldman, J. L., Dittenhafer-Reed, K. E., & Denu, J. M. (2012) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 248

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 171

Stoichiometry of site-specific lysine acetylation in an entire proteome

Baeza, J., Dowell, J. A., Smallegan, M. J., Fan, J., Amador-Noguez, D., Khan, Z., & Denu, J. M. (2014) · Journal of Biological Chemistry

Advanced Proteomics Techniques and ApplicationsUbiquitin and proteasome pathways

Cited by 154

Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation

Still, A. J., Floyd, B. J., Hebert, A. S., Bingman, C. A., Carson, J. J., Gunderson, D. R., Dolan, B. K., Grimsrud, P. A., Dittenhafer-Reed, K. E., Stapleton, D. S., et al. (2013) · Journal of Biological Chemistry

Advanced Proteomics Techniques and ApplicationsSirtuins and Resveratrol in Medicine

Cited by 123

Identification of and molecular basis for sirt6 loss-of-function point mutations in cancer

Kugel, S., Feldman, J. L., Klein, M. A., Silberman, D. M., Sebastián, C., Mermel, C., Dobersch, S., Clark, A. R., Getz, G., Denu, J. M., et al. (2015) · Cell Reports

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 81

SIRT3 substrate specificity determined by peptide arrays and machine learning

Smith, B. C., Settles, B., Hallows, W. C., Craven, M. W., & Denu, J. M. (2011) · ACS Chemical Biology

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 80

[29] Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: Detecting sulfenic acid intermediates and examining reversible inactivation

Denu, J. M., & Tanner, K. G. (2002) · Methods in Enzymology

Protein Tyrosine PhosphatasesRedox biology and oxidative stress

Cited by 50

Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases

Langer, M. R., Fry, C. J., Peterson, C. L., & Denu, J. M. (2002) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 45