Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

Lin, Wensheng; Kemper, April; Dupree, Jeffrey L.; Harding, Heather P.; Ron, David; Popko, Brian

doi:10.1093/brain/awl044

Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

Interferon-gamma (IFN-gamma) is believed to play a deleterious role in the immune-mediated demyelinating disorder multiple sclerosis. Here we have exploited transgenic mice that ectopically express IFN-gamma in a temporally controlled manner in the CNS to specifically study its effects on remyeli…