Shokat, Kevan M.

Expanding the scope of electrophiles capable of targeting K-Ras oncogenes

McGregor, L. M., Jenkins, M. L., Kerwin, C., Burke, J. E., & Shokat, K. M. (2017) · Biochemistry

Protein Kinase Regulation and GTPase SignalingClick Chemistry and Applications

Cited by 97

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Thorne, L. G., Bouhaddou, M., Reuschl, A.-K., Zuliani-Alvarez, L., Polacco, B., Pelin, A., Batra, J., Whelan, M. V. X., Ummadi, M., Rojc, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 Researchinterferon and immune responses

Cited by 91

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer

Donnella, H. J., Webber, J. T., Levin, R. S., Camarda, R., Momcilovic, O., Bayani, N., Shah, K. N., Korkola, J. E., Shokat, K. M., Goga, A., et al. (2018) · Nature Chemical Biology

PI3K/AKT/mTOR signaling in cancerAdvanced Breast Cancer Therapies

Cited by 90

MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development

Ultanir, S. K., Yadav, S., Hertz, N. T., Oses-Prieto, J. A., Claxton, S., Burlingame, A. L., Shokat, K. M., Jan, L. Y., & Jan, Y.-N. (2014) · Neuron

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 75

PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma

Tan, X., Banerjee, P., Pham, E. A., Rutaganira, F. U. N., Basu, K., Bota-Rabassedas, N., Guo, H.-F., Grzeskowiak, C. L., Liu, X., Yu, J., et al. (2020) · Science Translational Medicine

Cellular transport and secretionCancer, Lipids, and Metabolism

Cited by 70

Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin Proteins

Zhang, Z., & Shokat, K. M. (2019) · Angewandte Chemie International Edition

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 66

A kinase sequence database: sequence alignments and family assignment

Buzko, O., & Shokat, K. M. (2002) · Bioinformatics

Genomics and Phylogenetic StudiesBioinformatics and Genomic Networks

Cited by 58

IFITM proteins assist cellular uptake of diverse linked chemotypes

Lou, K., Wassarman, D. R., Yang, T., Paung, Y., Zhang, Z., O’Loughlin, T. A., Moore, M. K., Egan, R. K., Greninger, P., Benes, C. H., et al. (2022) · Science

Drug Transport and Resistance MechanismsRNA Interference and Gene Delivery

Cited by 42

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors

Ruiz-Saenz, A., Atreya, C. E., Wang, C., Pan, B., Dreyer, C. A., Brunen, D., Prahallad, A., Muñoz, D. P., Ramms, D. J., Burghi, V., et al. (2023) · Nature Cancer

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 39

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

Leyte-Vidal, A., DeFilippis, R., Outhwaite, I. R., Kwan, I., Lee, J. Y., Leavitt, C., Miller, K. B., Rea, D., Rangwala, A. M., Lou, K., et al. (2024) · Leukemia

Chronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia Research

Cited by 17

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

Li, H., Melnyk, J. E., Fu, B. X. H., Shrestha, R., Zhang, M., Sjöström, M., Feng, S., Anderson, J. A., Han, W., Chesner, L. N., et al. (2025) · Nature Genetics

Prostate Cancer Treatment and ResearchChromatin Remodeling and Cancer

Cited by 10

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Wassarman, D. R., Pfaff, P., Paulo, J. A., Gygi, S. P., Shokat, K. M., & Kranzusch, P. J. (2025) · Science

interferon and immune responsesBacteriophages and microbial interactions

Cited by 9

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Wassarman, D. R., Pfaff, P., Paulo, J. A., Gygi, S. P., Shokat, K. M., & Kranzusch, P. J. (2025) · Science

interferon and immune responsesBacteriophages and microbial interactions

Cited by 9