PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma
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This study identifies a molecular basis for malignant secretion and provides a rationale to test PI4KIIIβ antagonists as an intervention.
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Expression levels of Golgi apparatus-related genes (GARGs) are significantly correlated with clinical outcomes across various cancers, and their dysregulation is frequently associated with poorer prognosis.
“Additionally, the expression levels of Golgi apparatus-related genes (GARGs) are significantly correlated with clinical outcomes across various cancers, with their dysregulation frequently associated with poorer prognosis [12].”
From Construction and validation of golgi apparatus-related genes as predictors of the immune microenvironment and prognosis in colorectal cancer (2026) · cites this paper as [12]
The Results section, “A chromosome 1q amplicon links Golgi-related functions to metastasis” (page unavailable), links higher expression of a 1q21.3 gene signature and PI4KB mRNA to worse prognosis in lung adenocarcinoma. It identifies 1q amplification in several cancer types, but does not establish that Golgi-related gene expression is significantly correlated with clinical outcomes across those cancers. (LLM, conf=0.88)
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- [59]Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu X, Liu CG, Creighton CJ, Wistuba II, Kurie JM, The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest 128, 3198 (2018). 30108197 PMC6025981
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- Authors
- Tan, X., Banerjee, P., Pham, E. A., Rutaganira, F. U. N., Basu, K., Bota-Rabassedas, N., Guo, H.-F., Grzeskowiak, C. L., Liu, X., Yu, J., Shi, L., Peng, D. H., Rodriguez, B. L., Zhang, J., Zheng, V., Duose, D. Y., Solis, L. M., Mino, B., Raso, M. G., Behrens, C., Wistuba, I. I., Scott, K. L., Smith, M., Nguyen, K., Lam, G., Choong, I., Mazumdar, A., Hill, J. L., Gibbons, D. L., Brown, P. H., Russell, W. K., Shokat, K., Creighton, C. J., Glenn, J. S., & Kurie, J. M.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- Baylor College of Medicine (US)
- The University of Texas Medical Branch at Galveston (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Creighton, Chad J.
- Glenn, Jeffrey S.
- Kurie, Jonathan M.
- ORCID
- Tan, Xiaochao
- Banerjee, Priyam
- Pham, Edward A.
- Rutaganira, Florentine U. N.
- Guo, Hou-Fu
- Grzeskowiak, Caitlin L.
- Liu, Xin
- Shi, Lei
- Peng, David H.
- Rodriguez, B. Leticia
- Zhang, Jiaqi
- Zheng, Veronica
- Duose, Dzifa Y.
- Solis, Luisa M.
- Mino, Barbara
- Raso, Maria Gabriela
- Behrens, Carmen
- Wistuba, Ignacio I.
- Smith, Mark
- Lam, Grace
- Mazumdar, Abhijit
- Hill, Jamal L.
- Gibbons, Don L.
- Brown, Powel H.
- Russell, William K.
- Shokat, Kevan
- Creighton, Chad J.
- Glenn, Jeffrey S.
- Kurie, Jonathan M.
- Venue
- Science Translational Medicine
- Published
- 2020-01-22
- Volume
- 12
- Issue
- 527
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7702266
- OpenAlex
- W3002682909
- Cited by
- 70
- References
- 78
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 9 · 2020: 5
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01 CA181184, R01 CA2111125, CA125123, CA225633)
- NIH Office of the Director (R01 AI099245, U19 AI109622)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- PI4KIIIβ, chromosome 1q amplification, lung adenocarcinoma, GOLPH3, Golgi trafficking, tumor cell secretion, metastasis, tumor microenvironment, apoptosis, therapeutic target
- MeSH terms
- Adenocarcinoma of Lung, Animals, Chromosomes, Human, Pair 1, Enzyme-Linked Immunosorbent Assay, Golgi Apparatus, Humans, Membrane Proteins, Phosphotransferases (Alcohol Group Acceptor), Mice, X-Ray Microtomography, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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