Shadel, Gerald S.

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,975

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature

Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 1,659

Mitochondria in innate immune responses

West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology

Immune Response and InflammationMitochondrial Function and Pathology

Cited by 1,376

Mitochondrial ROS Signaling in Organismal Homeostasis

Shadel, G. S., & Horvath, T. L. (2015) · Cell

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 1,353

Mitochondrial DNA in innate immune responses and inflammatory pathology

West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology

Immune Response and Inflammationinterferon and immune responses

Cited by 1,115

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity

Inflammasome and immune disordersMitochondrial Function and Pathology

Cited by 850

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell

interferon and immune responsesCell death mechanisms and regulation

Cited by 847

Replicative and chronological aging in Saccharomyces cerevisiae

Longo, V. D., Shadel, G. S., Kaeberlein, M., & Kennedy, B. (2012) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 595

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y., & Shadel, G. S. (2007) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 422

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 319

Epigenetic silencing mediates mitochondria stress-induced longevity

Schroeder, E. A., Raimundo, N., & Shadel, G. S. (2013) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 186

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., et al. (2025) · Science

Cancer Immunotherapy and BiomarkersDrug Transport and Resistance Mechanisms

Cited by 177

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

Schwartz, R. E., Shokhirev, M. N., Andrade, L. R., Gutkind, J. S., Iglesias-Bartolome, R., & Shadel, G. S. (2021) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23