Bradley, Allan

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature

Cancer-related Molecular PathwaysDevelopmental Biology and Gene Regulation

Cited by 4,649

Identification of Mammalian microRNA Host Genes and Transcription Units

Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L., & Bradley, A. (2004) · Genome Research

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 2,128

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

Kosicki, M., Tomberg, K., & Bradley, A. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,883

Requirement of bic/microRNA-155 for Normal Immune Function

Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science

MicroRNA in disease regulationT-cell and B-cell Immunology

Cited by 1,833

A conditional knockout resource for the genome-wide study of mouse gene function

Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 1,708

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,625

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature

Genetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

Cited by 1,459

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Jones, S. N., Roe, A. E., Donehower, L. A., & Bradley, A. (1995) · Nature

Cancer-related Molecular PathwaysDevelopmental Biology and Gene Regulation

Cited by 1,280

High-throughput discovery of novel developmental phenotypes

The International Mouse Phenotyping Consortium, Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., et al. (2016) · Nature

Genomics and Rare DiseasesZebrafish Biomedical Research Applications

Cited by 1,196

Impaired Energy Homeostasis in C/EBPα Knockout Mice

Wang, N.-D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R., & Darlington, G. J. (1995) · Science

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 929

Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.

Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell

Circadian rhythm and melatoninPlant Molecular Biology Research

Cited by 900

The mPer2 gene encodes a functional component of the mammalian circadian clock

Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature

Circadian rhythm and melatoninSleep and Work-Related Fatigue

Cited by 718

Functional analysis of activins during mammalian development

Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature

Developmental Biology and Gene RegulationCleft Lip and Palate Research

Cited by 578

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

Harvey, M., McArthur, M. J., Montgomery, C. A., Butel, J. S., Bradley, A., & Donehower, L. A. (1993) · Nature Genetics

Cancer-related Molecular PathwaysCarcinogens and Genotoxicity Assessment

Cited by 542

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White, J. K., Gerdin, A.-K., Karp, N. A., Ryder, E., Buljan, M., Bussell, J. N., Salisbury, J., Clare, S., Ingham, N. J., Podrini, C., et al. (2013) · Cell

Genomics and Rare DiseasesAnimal Genetics and Reproduction

Cited by 509

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism

Nakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S., Watanabe, Y., Chung, Y. J., Banerjee, R., et al. (2009) · Cell

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 482

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

Mali, P., Chou, B.-K., Yen, J., Ye, Z., Zou, J., Dowey, S., Brodsky, R. A., Ohm, J. E., Yu, W., Baylin, S. B., et al. (2010) · Stem Cells

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 417

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

Jones, S. N., Hancock, A. R., Vogel, H., Donehower, L. A., & Bradley, A. (1998) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 386

An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease

Pardo, M., Lang, B., Yu, L., Prosser, H., Bradley, A., Babu, M. M., & Choudhary, J. (2010) · Cell Stem Cell

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 379

Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

Rouhani, F., Kumasaka, N., de Brito, M. C., Bradley, A., Vallier, L., & Gaffney, D. (2014) · PLoS Genetics

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 294

Effects of genetic background on tumorigenesis in p53‐deficient mice

Donehower, L. A., Harvey, M., Vogel, H., McArthur, M. J., Montgomery, C. A., Park, S. H., Thompson, T., Ford, R. J., & Bradley, A. (1995) · Molecular Carcinogenesis

Cancer-related Molecular PathwaysCarcinogens and Genotoxicity Assessment

Cited by 252

Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene

Hoff, A. O., Catala-Lehnen, P., Thomas, P. M., Priemel, M., Rueger, J. M., Nasonkin, I., Bradley, A., Hughes, M. R., Ordonez, N., Cote, G. J., et al. (2002) · Journal of Clinical Investigation

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 209

Cas9-induced large deletions and small indels are controlled in a convergent fashion

Kosicki, M., Allen, F., Steward, F., Tomberg, K., Pan, Y., & Bradley, A. (2022) · Nature Communications

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 115

Inter-homologue repair in fertilized human eggs?

Egli, D., Zuccaro, M. V., Kosicki, M., Church, G. M., Bradley, A., & Jasin, M. (2018) · Nature

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 111