Harris, Adrian L.

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

McIntyre, A., Patiar, S., Wigfield, S., Li, J.-L., Ledaki, I., Turley, H., Leek, R., Snell, C., Gatter, K., Sly, W. S., et al. (2012) · Clinical Cancer Research

Enzyme function and inhibitionCancer, Hypoxia, and Metabolism

Cited by 239

Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer

Vleugel, M. M., Greijer, A. E., Shvarts, A., van der Groep, P., van Berkel, M., Aarbodem, Y., van Tinteren, H., Harris, A. L., van Diest, P. J., & van der Wall, E. (2005) · Journal of Clinical Pathology

Cancer, Hypoxia, and MetabolismBreast Cancer Treatment Studies

Cited by 227

Association of hypoxia‐inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

Sivridis, E., Giatromanolaki, A., Gatter, K. C., Harris, A. L., Koukourakis, M. I., & for the Tumor and Angiogenesis Research Group (2002) · Cancer

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 218

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma

Koukourakis, M. I., Giatromanolaki, A., Sivridis, E., Gatter, K. C., & Harris, A. L. (2005) · Neoplasia

Cancer, Hypoxia, and MetabolismBiochemical Acid Research Studies

Cited by 214

Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines.

Koukourakis, M. I., Kalamida, D., Giatromanolaki, A., Zois, C. E., Sivridis, E., Pouliliou, S., Mitrakas, A., Gatter, K. C., & Harris, A. L. (2015) · PLoS ONE

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 183

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Morotti, M., Bridges, E., Valli, A., Choudhry, H., Sheldon, H., Wigfield, S., Gray, N., Zois, C. E., Grimm, F., Jones, D., et al. (2019) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismEstrogen and related hormone effects

Cited by 131

Glutamine deprivation alters the origin and function of cancer cell exosomes

Fan, S., Kroeger, B., Marie, P. P., Bridges, E. M., Mason, J. D., McCormick, K., Zois, C. E., Sheldon, H., Khalid Alham, N., Johnson, E., et al. (2020) · The EMBO Journal

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 130

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients

Yang, L., Taylor, J., Eustace, A., Irlam, J. J., Denley, H., Hoskin, P. J., Alsner, J., Buffa, F. M., Harris, A. L., Choudhury, A., et al. (2017) · Clinical Cancer Research

Bladder and Urothelial Cancer TreatmentsCancer, Hypoxia, and Metabolism

Cited by 123

The tumour hypoxia induced non-coding transcriptome

Choudhry, H., Harris, A. L., & McIntyre, A. (2016) · Molecular Aspects of Medicine

Cancer, Hypoxia, and MetabolismCancer-related molecular mechanisms research

Cited by 120

Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin

Swietach, P., Hulikova, A., Patiar, S., Vaughan-Jones, R. D., & Harris, A. L. (2012) · PLoS ONE

Drug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery

Cited by 109

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer

Giatromanolaki, A., Koukourakis, M. I., Sivridis, E., Turley, H., Wykoff, C. C., Gatter, K. C., & Harris, A. L. (2003) · The Journal of Pathology

Cancer, Hypoxia, and MetabolismLung Cancer Research Studies

Cited by 100

Normoxic stabilization of hypoxia-inducible factor-1α by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

Knowles, H. J., Mole, D. R., Ratcliffe, P. J., & Harris, A. L. (2006) · Cancer Research

Cancer, Hypoxia, and MetabolismIron Metabolism and Disorders

Cited by 94

Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

Biswas, S., Troy, H., Leek, R., Chung, Y.-L., Li, J.-L., Raval, R. R., Turley, H., Gatter, K., Pezzella, F., Griffiths, J. R., et al. (2010) · Journal of Oncology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 89

A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis

Williams, K. J., Telfer, B. A., Airley, R. E., Peters, H. P., Sheridan, M. R., van der Kogel, A. J., Harris, A. L., & Stratford, I. J. (2002) · Oncogene

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 81

Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways

Valli, A., Rodriguez, M., Moutsianas, L., Fischer, R., Fedele, V., Huang, H.-L., Van Stiphout, R., Jones, D., Mccarthy, M., Vinaxia, M., et al. (2015) · Oncotarget

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 79

Effects of Transferrin Receptor Blockade on Cancer Cell Proliferation and Hypoxia-Inducible Factor Function and Their Differential Regulation by Ascorbate

Jones, D. T., Trowbridge, I. S., & Harris, A. L. (2006) · Cancer Research

Cancer, Hypoxia, and MetabolismIron Metabolism and Disorders

Cited by 75

HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia

Nilsson, H., Jögi, A., Beckman, S., Harris, A. L., Poellinger, L., & Påhlman, S. (2005) · Experimental Cell Research

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 75

Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers

Zhang, X., Gee, H., Rose, B., Lee, C. S., Clark, J., Elliott, M., Gamble, J. R., Cairns, M. J., Harris, A., Khoury, S., et al. (2016) · BMC Cancer

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 65

Machine learning to guide the use of adjuvant therapies for breast cancer

Alaa, A. M., Gurdasani, D., Harris, A. L., Rashbass, J., & van der Schaar, M. (2021) · Nature Machine Intelligence

Breast Cancer Treatment StudiesAI in cancer detection

Cited by 55

The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway

Leek, R. D., Stratford, I., & Harris, A. L. (2005) · Cancer Research

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 53

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis

Singleton, D. C., Rouhi, P., Zois, C. E., Haider, S., Li, J.-L., Kessler, B. M., Cao, Y., & Harris, A. L. (2015) · Oncogene

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 52

Novel Thioredoxin Inhibitors Paradoxically Increase Hypoxia-Inducible Factor-α Expression but Decrease Functional Transcriptional Activity, DNA Binding, and Degradation

Jones, D. T., Pugh, C. W., Wigfield, S., Stevens, M. F. G., & Harris, A. L. (2006) · Clinical Cancer Research

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 48

Guidelines for using sigQC for systematic evaluation of gene signatures

Dhawan, A., Barberis, A., Cheng, W.-C., Domingo, E., West, C., Maughan, T., Scott, J. G., Harris, A. L., & Buffa, F. M. (2019) · Nature Protocols

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 31

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

Golinska, M., Troy, H., Chung, Y.-L., McSheehy, P. M., Mayr, M., Yin, X., Ly, L., Williams, K. J., Airley, R. E., Harris, A. L., et al. (2011) · BMC Cancer

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 29