The tumour hypoxia induced non-coding transcriptome

Choudhry, Hani; Harris, Adrian L.; McIntyre, Alan

doi:10.1016/j.mam.2016.01.003

Cited by 122Cancer, Hypoxia, and MetabolismCancer-related molecular mechanisms researchMicroRNA in disease regulation

The tumour hypoxia induced non-coding transcriptome

Choudhry, Hani, Harris, Adrian L., McIntyre, Alan·2016·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2016.01.003

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Abstract

Recent investigations have highlighted the importance of the non-coding genome in regions of hypoxia in tumours. Such regions are frequently found in solid tumours, and are associated with worse patient survival and therapy resistance. Hypoxia stabilises the transcription factors, hypoxia inducible factors (HIF1α and HIF2α) which coordinate transcriptomic changes that occur in hypoxia. The changes in gene expression induced by HIF1α and HIF2α contribute to many of the hallmarks of cancer phenotypes and enable tumour growth, survival and invasion in the hypoxic tumour microenvironment. Non-coding RNAs, in particular microRNAs (miRNAs), which regulate mRNA stability and translation, and long-non-coding RNAs (lncRNAs), which have diverse functions including chromatin modification and transcriptional regulation, are also important in enabling the key hypoxia regulated processes. They have roles in the regulation of metabolism, angiogenesis, autophagy, invasion and metastasis in the hypoxic microenvironment. Furthermore, HIF1α and HIF2α expression and stabilisation are also regulated by both miRNAs and lncRNAs. Here we review the recent developments in the expression, regulation and functions of miRNAs, lncRNAs and other non-coding RNA classes in tumour hypoxia.

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A large number of miRNAs have been identified as being regulated by hypoxia and mediate events such as cell proliferation, differentiation, invasion and metastasis that are relevant to placental biology.
“A large number of miRNAs have been identified from the field of cancer biology as being regulated by hypoxia, and mediate events such as cell proliferation, differentiation, invasion and metastasis that are relevant to placental biology (109, 499).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [109]

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A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma
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MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers
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MiR-338-3p Inhibits Hepatocarcinoma Cells and Sensitizes These Cells to Sorafenib by Targeting Hypoxia-Induced Factor 1α
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The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic Intervention
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aHIF but not HIF-1α transcript is a poor prognostic marker in human breast cancer
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HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFβ-signaling in hypoxic microenvironment.
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MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells
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An Insertion/Deletion Polymorphism within RERT-lncRNA Modulates Hepatocellular Carcinoma Risk
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Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis
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Gene expression and hypoxia in breast cancer
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Regulation of angiogenesis by hypoxia: the role of microRNA
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Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis
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Hypoxia-Responsive MicroRNA-101 Promotes Angiogenesis via Heme Oxygenase-1/Vascular Endothelial Growth Factor Axis by Targeting Cullin 3
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miRNAs in pancreatic cancer: Therapeutic potential, delivery challenges and strategies
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H19 expression in hepatic metastases from a range of human carcinomas
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A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients
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Small nucleolar RNAs functioning and potential roles in cancer
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The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer
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A novel long non-coding RNA, hypoxia-inducible factor-2α promoter upstream transcript, functions as an inhibitor of osteosarcoma stem cells in vitro
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Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells
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MicroRNA-15b enhances hypoxia/reoxygenation-induced apoptosis of cardiomyocytes via a mitochondrial apoptotic pathway
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Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer
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Long Noncoding RNA HOTAIR as an Independent Prognostic Marker in Cancer: A Meta-Analysis
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Upregulation of H19 promotes invasion and induces epithelial-to-mesenchymal transition in esophageal cancer
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MicroRNA-210 Promotes Proliferation and Invasion of Peripheral Nerve Sheath Tumor Cells Targeting EFNA3
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Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
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Distinct micro RNA expression signatures are associated with melanoma subtypes and are regulated by HIF 1A
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Overexpression of the natural antisense hypoxia-inducible factor-1 transcript is associated with malignant pheochromocytoma/paraganglioma
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History, Discovery, and Classification of lncRNAs
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Placental Origins of Chronic Disease
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Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis
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A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability
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Authors: Choudhry, H., Harris, A. L., & McIntyre, A.
Affiliations: King Abdulaziz University (SA)
University of Oxford (GB)
University of Nottingham (GB)
Corresponding author: Harris, Adrian L.
McIntyre, Alan
ORCID: Choudhry, Hani
Harris, Adrian L.
McIntyre, Alan
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2016-02
Volume: 47-48
Pages: 35-53
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2016.01.003
OpenAlex: W2264671620
Cited by: 120
References: 155
Citations by year: 2026: 1 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 15 · 2021: 21 · 2020: 24 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 4
FWCI: 1.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research UK (C602/A18974)
Breast Cancer Research Foundation
Deanship of Scientific Research (DSR), King Abdulaziz University, Saudi Arabia (G-1436-130-284)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords: tumor hypoxia, non-coding RNA, microRNA, long non-coding RNA, hypoxia-inducible factor, HIF-1α, HIF-2α, tumor microenvironment, treatment resistance, metastasis, angiogenesis, autophagy, cancer metabolism, gene expression regulation
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Hypoxia, Gene Expression Regulation, Humans, Neoplasms, Neovascularization, Pathologic, MicroRNAs, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Transcriptome, RNA, Long Noncoding

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The tumour hypoxia induced non-coding transcriptome

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