Eisenberg, David

Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science

Immune Response and InflammationVitamin D Research Studies

Cited by 3,924

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

Bowie, J. U., Lüthy, R., & Eisenberg, D. (1991) · Science

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 2,851

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 2,012

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

Marcotte, E. M., Pellegrini, M., Ng, H.-L., Rice, D. W., Yeates, T. O., & Eisenberg, D. (1999) · Science

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 1,670

Profile analysis: detection of distantly related proteins.

Gribskov, M., McLachlan, A. D., & Eisenberg, D. (1987) · Proceedings of the National Academy of Sciences

Genomics and Phylogenetic StudiesProtein Structure and Dynamics

Cited by 1,325

The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

Hsu, T., Hingley-Wilson, S. M., Chen, B., Chen, M., Dai, A. Z., Morin, P. M., Marks, C. B., Padiyar, J., Goulding, C., Gingery, M., et al. (2003) · Proceedings of the National Academy of Sciences

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 731

3D domain swapping: As domains continue to swap

Liu, Y., & Eisenberg, D. (2002) · Protein Science

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 684

Propagation of Tau aggregates and neurodegeneration

Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 632

The HUPO PSI's Molecular Interaction format—a community standard for the representation of protein interaction data

Hermjakob, H., Montecchi-Palazzi, L., Bader, G., Wojcik, J., Salwinski, L., Ceol, A., Moore, S., Orchard, S., Sarkans, U., von Mering, C., et al. (2004) · Nature Biotechnology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 630

The expanding amyloid family: Structure, stability, function, and pathogenesis

Sawaya, M. R., Hughes, M. P., Rodriguez, J. A., Riek, R., & Eisenberg, D. S. (2021) · Cell

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 475

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Thai-Quynh Nguyen, A., Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., et al. (2016) · Cancer Cell

Cancer-related Molecular PathwaysOvarian cancer diagnosis and treatment

Cited by 341

Broadening the horizon – level 2.5 of the HUPO-PSI format for molecular interactions

Kerrien, S., Orchard, S., Montecchi-Palazzi, L., Aranda, B., Quinn, A. F., Vinod, N., Bader, G. D., Xenarios, I., Wojcik, J., Sherman, D., et al. (2007) · BMC Biology

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 266

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

Boyer, D. R., Li, B., Sun, C., Fan, W., Zhou, K., Hughes, M. P., Sawaya, M. R., Jiang, L., & Eisenberg, D. S. (2020) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 179

Ketones block amyloid entry and improve cognition in an Alzheimer's model

Yin, J. X., Maalouf, M., Han, P., Zhao, M., Gao, M., Dharshaun, T., Ryan, C., Whitelegge, J., Wu, J., Eisenberg, D., et al. (2016) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDiet and metabolism studies

Cited by 151

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

Griner, S. L., Seidler, P., Bowler, J., Murray, K. A., Yang, T. P., Sahay, S., Sawaya, M. R., Cascio, D., Rodriguez, J. A., Philipp, S., et al. (2019) · eLife

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 121

Inhibition of synucleinopathic seeding by rationally designed inhibitors

Sangwan, S., Sahay, S., Murray, K. A., Morgan, S., Guenther, E. L., Jiang, L., Williams, C. K., Vinters, H. V., Goedert, M., & Eisenberg, D. S. (2020) · eLife

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 79

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., et al. (2018) · Nature Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 75

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples

Seidler, P. M., Boyer, D. R., Murray, K. A., Yang, T. P., Bentzel, M., Sawaya, M. R., Rosenberg, G., Cascio, D., Williams, C. K., Newell, K. L., et al. (2019) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 70

A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils

Saelices, L., Nguyen, B. A., Chung, K., Wang, Y., Ortega, A., Lee, J. H., Coelho, T., Bijzet, J., Benson, M. D., & Eisenberg, D. S. (2019) · Journal of Biological Chemistry

Amyloidosis: Diagnosis, Treatment, OutcomesAlzheimer's disease research and treatments

Cited by 43