Maeda, Hiroshi

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 6,565

The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

Maeda, H. (2001) · Advances in Enzyme Regulation

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 2,495

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 2,376

Exploiting the enhanced permeability and retention effect for tumor targeting

Iyer, A. K., Khaled, G., Fang, J., & Maeda, H. (2006) · Drug Discovery Today

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 1,846

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

Maeda, H. (2015) · Advanced Drug Delivery Reviews

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 1,179

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Fang, J., Islam, W., & Maeda, H. (2020) · Advanced Drug Delivery Reviews

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 757

The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery—Personal Remarks and Future Prospects

Maeda, H. (2021) · Journal of Personalized Medicine

Nanoparticle-Based Drug DeliveryUltrasound and Hyperthermia Applications

Cited by 167

EPR-Effect Enhancers Strongly Potentiate Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect

Islam, W., Kimura, S., Islam, R., Harada, A., Ono, K., Fang, J., Niidome, T., Sawa, T., & Maeda, H. (2021) · Journal of Personalized Medicine

Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

Cited by 30

Antitumor activity of rice‐shochu post‐distillation slurry and vinegar produced from the post‐distillation slurry via oral administration in a mouse model

Seki, T., Morimura, S., Shigematsu, T., Maeda, H., & Kida, K. (2004) · BioFactors

Food Quality and Safety StudiesFermentation and Sensory Analysis

Cited by 25