Agard, David A.

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

Wilson, C., Wardell, M. R., Weisgraber, K. H., Mahley, R. W., & Agard, D. A. (1991) · Science

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 678

Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements

Shiau, A. K., Harris, S. F., Southworth, D. R., & Agard, D. A. (2006) · Cell

Heat shock proteins researchProtein Structure and Dynamics

Cited by 455

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Verba, K. A., Wang, R. Y.-R., Arakawa, A., Liu, Y., Shirouzu, M., Yokoyama, S., & Agard, D. A. (2016) · Science

Heat shock proteins researchProtein Structure and Dynamics

Cited by 424

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

Kirschke, E., Goswami, D., Southworth, D., Griffin, P. R., & Agard, D. A. (2014) · Cell

Heat shock proteins researchProtein Structure and Dynamics

Cited by 399

Human apolipoprotein E: Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

Dong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., & Agard, D. A. (1994) · Journal of Biological Chemistry

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 320

Conformational dynamics of the molecular chaperone Hsp90

Krukenberg, K. A., Street, T. O., Lavery, L. A., & Agard, D. A. (2011) · Quarterly Reviews of Biophysics

Heat shock proteins researchProtein Structure and Dynamics

Cited by 308

Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism

Wang, R. Y.-R., Noddings, C. M., Kirschke, E., Myasnikov, A. G., Johnson, J. L., & Agard, D. A. (2022) · Nature

Heat shock proteins researchProtein Structure and Dynamics

Cited by 220

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

Noddings, C. M., Wang, R. Y.-R., & Agard, D. A. (2020) · Nature

Heat shock proteins researchProtein Structure and Dynamics

Cited by 166

Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism

Noddings, C. M., Wang, R. Y.-R., Johnson, J. L., & Agard, D. A. (2022) · Nature

Heat shock proteins researchProtein Structure and Dynamics

Cited by 164

Multiple Conformations of E. coli Hsp90 in Solution: Insights into the Conformational Dynamics of Hsp90

Krukenberg, K. A., Förster, F., Rice, L. M., Sali, A., & Agard, D. A. (2008) · Structure

Heat shock proteins researchProtein Structure and Dynamics

Cited by 160

Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex

Southworth, D. R., & Agard, D. A. (2011) · Molecular Cell

Heat shock proteins researchProtein Structure and Dynamics

Cited by 143

Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast

Genest, O., Reidy, M., Street, T. O., Hoskins, J. R., Camberg, J. L., Agard, D. A., Masison, D. C., & Wickner, S. (2013) · Molecular Cell

Heat shock proteins researchBacterial Genetics and Biotechnology

Cited by 118

Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

Wolff, G., Limpens, R. W. A. L., Zheng, S., Snijder, E. J., Agard, D. A., Koster, A. J., & Bárcena, M. (2019) · Journal of Structural Biology

Advanced Electron Microscopy Techniques and ApplicationsAdvanced Materials Characterization Techniques

Cited by 115

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

Morgner, N., Schmidt, C., Beilsten-Edmands, V., Ebong, I.-O., Patel, N. A., Clerico, E. M., Kirschke, E., Daturpalli, S., Jackson, S. E., Agard, D., et al. (2015) · Cell Reports

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 106

Mechanistic studies of Sansalvamide A-amide: An allosteric modulator of Hsp90

Vasko, R. C., Rodriguez, R. A., Cunningham, C. N., Ardi, V. C., Agard, D. A., & McAlpine, S. R. (2010) · ACS Medicinal Chemistry Letters

Heat shock proteins researchProtein Degradation and Inhibitors

Cited by 105

Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.

Wilson, C., Mau, T., Weisgraber, K. H., Wardell, M. R., Mahley, R. W., & Agard, D. A. (1994) · Structure

Protein Structure and DynamicsLipoproteins and Cardiovascular Health

Cited by 100

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

Gupta, M., Azumaya, C. M., Moritz, M., Pourmal, S., Diallo, A., Merz, G. E., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A. F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 ResearchAdvanced Electron Microscopy Techniques and Applications

Cited by 89

De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography

Chen, Z., Shiozaki, M., Haas, K. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Kaake, R. M., Vale, R. D., et al. (2022) · Cell

Advanced Electron Microscopy Techniques and ApplicationsSperm and Testicular Function

Cited by 82

De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking

Chen, Z., Shiozaki, M., Haas, K. M., Skinner, W. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Lishko, P. V., et al. (2023) · Cell

Advanced Electron Microscopy Techniques and ApplicationsSperm and Testicular Function

Cited by 82

Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor

Noddings, C. M., Johnson, J. L., & Agard, D. A. (2023) · Nature Structural & Molecular Biology

Heat shock proteins researchProtein Structure and Dynamics

Cited by 75

High-performance iterative electron tomography reconstruction with long-object compensation using graphics processing units (GPUs)

Xu, W., Xu, F., Jones, M., Keszthelyi, B., Sedat, J., Agard, D., & Mueller, K. (2010) · Journal of Structural Biology

Advanced Electron Microscopy Techniques and ApplicationsParallel Computing and Optimization Techniques

Cited by 71

On the efficiency of iterative ordered subset reconstruction algorithms for acceleration on GPUs

Xu, F., Xu, W., Jones, M., Keszthelyi, B., Sedat, J., Agard, D., & Mueller, K. (2010) · Computer Methods and Programs in Biomedicine

Medical Imaging Techniques and ApplicationsParallel Computing and Optimization Techniques

Cited by 63

The ΦPA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

Nieweglowska, E., Brilot, A., Méndez-Moran, M., Baek, M., Li, J., Kokontis, C., Cheng, Y., Baker, D., Bondy-Denomy, J., & Agard, D. (2022) · Nature Communications

Bacteriophages and microbial interactionsAdvanced Electron Microscopy Techniques and Applications

Cited by 45